Academia

The study identifies the tumor-suppressing protein p53 as a working partner of “speckles,” nuclear structures that contain proteins and RNA involved in gene expression.

An ongoing multicenter study in Japan will evaluate reductions in pulmonary vascular resistance 8 months after initiating the combination therapy in pulmonary arterial hypertension.

Penn Medicine's Stephen Schuster, MD, offers an overview of an eventful year in CAR T-cell therapy at the NCCN Virtual Annual Meeting.

Researchers analyzed 2 cohorts of patients with chronic obstructive pulmonary disease (COPD) to characterize who is most at risk for developing hypercapnia and who could most benefit from at-home noninvasive inhalation therapy.

The specialization program will teach fundamentals and offer real-world examples of value-based care through an online program.

While diagnostic algorithms have evolved in the last decade, there remains an urgent need for innovative therapeutic options to treat systemic sclerosis with pulmonary arterial hypertension.

Cutting-edge genetic tools diagnosed 83% of Irish patients with polycystic kidney disease (PKD), identified 36 novel variants, and discovered that seemingly unrelated individuals with the same variant likely inherited it from a common ancestor.

Nanotherapies have the potential to overcome the blood-brain barrier and the blood-cerebrospinal fluid barrier, representing a possible treatment opportunity for rare diseases.

Break Through Cancer, a collaborative research effort between 5 top US academic cancer centers, aims to pursue solutions to some of the most difficult challenges in cancer research.

Multicancer early detection technology could help reduce cancer mortality compared to the current strategy of single-cancer screening tests.

Older adults are often at greater risk for adverse events from treatments, but they can also be excluded from randomized controlled trials (RCTs), making it difficult to know if findings are generalizable to this population.

Researchers from the University of California San Francisco published their results in the Journal of Urology.

In the real world, the persistence rate with secukinumab to treat psoriatic arthritis was higher than with ustekinumab.

Results of the artificial intelligence (AI) model were consistent no matter which immune checkpoint inhibitor (ICI) therapy patients received, suggesting that some biomarkers are not necessarily specific to the checkpoint target.

The mortality risk differs for the 3 endothelin receptor antagonists approved to treat pulmonary arterial hypertension (PAH) in elderly patients; however, a direct comparison in a controlled trial is still needed to confirm results.

Understanding these genetic variants discovered through sequencing efforts is key to further progress in clinical genetics.

Newer therapies have led to a boost in the number of patients with relapsed or refractory multiple myeloma (R/R MM) who are prescribed triplet regimens. As that shift has occurred, death rates appear to have dropped.

The use of estimated glomerular filtration rate (eGFR) equations in assessing chronic kidney disease (CKD) for Black patients may lead to underdiagnosis and undertreatment, according to a nephrologist speaking at Kidney Week.

Air pollution was found to be significantly associated with an increased risk of hospital admissions for several neurological disorders, including Parkinson disease, Alzheimer disease, and other dementias.

Attendees at the Academy of Managed Care Pharmacy (AMCP) Nexus 2020 meeting will hear a keynote from a surgeon who has become more visible over the past year and a half discussing what he says are “structural problems” behind the cost of US health care.

A recent analysis illustrated how a combination of different genomic approaches discovered actionable alterations in 44% of patients with metastatic breast cancer.

Differences in clinical and demographic characteristics between men and women with multiple sclerosis (MS) are more prevalent regarding disease course than they are when stratifying by sex.

The United States has its first reported of coronavirus disease 2019 (COVID-19) reinfection, in a young male patient with no underlying immune conditions.

A recent study about the impact of spinal muscular atrophy (SMA) on patients and caregivers may help to illustrate the impact of future improvements as new therapies take hold, but more targeted SMA quality-of life-outcome measures may be needed to fully the changes.

Two women are awarded the Nobel Prize in Chemistry for CRISPR; Eli Lilly partners with DexCom, Inc; the US arm of AstraZeneca’s coronavirus disease 2019 (COVID-19) vaccine trial remains halted.

Two neurologists discuss what is known and unknown in switching patients with migraine from one calcitonin gene-related peptide (CGRP) inhibitor to another.

The National Insistutes of Health (NIH) study aims to discover new forms of diabetes, understand what makes them unique, and identify root causes.

Two Americans and a British scientist share the 2020 Prize for Physiology or Medicine for work in the 1970s through the 1990s. The rise of agents to treat hepatitis C virus has created vexing questions in managed care.

During a 1-hour free webinar from MJH Life Sciences™’s COVID-19 Coalition, experts discussed various myths around the coronavirus disease 2019 (COVID-19) pandemic.