Myasthenia Gravis

Latest News
December 19th 2024

Further Refining the Myasthenia Gravis Continuum

December 17th 2024

Analysis Offers Insight Into Most Effective Treatment for MG

December 7th 2024

Clinical Features Vary Across Myasthenia Gravis Foundation Classes

December 3rd 2024

Laryngeal MG Is Best Diagnosed With a Tensilon Test or Pyridostigmine Bromide Trial

November 26th 2024

Analysis of Sleep, Exercise, and Symptoms Recommended for Optimal Myasthenia Gravis Care

Video Interviews
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June 17th 2023

Dr James Howard Explains Mechanisms of Action of Newer Myasthenia Gravis Therapies

June 10th 2023

Dr James Howard on the Malfunctions in the Neuromuscular Junction

June 2nd 2023

Unmet Needs in Myasthenia Gravis Are Numerous, Says Dr James Howard

May 26th 2023

Dr James Howard on the Complications of Standard Myasthenia Gravis Therapies

May 19th 2023

Step Therapy Requirements Are Worsening, Says Dr James Howard

April 13th 2023

Patient Needs, Antibody Subtype Should Guide Myasthenia Gravis Therapy, Says Dr James Howard

More News

Respiratory infections like COVID-19 are known to exacerbate MG | image credit: Cutie - stock.adobe.com
November 22nd 2024

COVID-19 Infection Raises Myasthenia Gravis Exacerbation Risk, Study Finds

Kimberly Rath, PharmD
A new study shows that COVID-19 infection significantly increases the risk of exacerbation in patients with myasthenia gravis (MG).
doctor and patient | Image Credit: © Halfpoint - stock.adobe.com
November 20th 2024

Understanding Patient Perspectives Around Myasthenia Gravis Treatment May Help Optimize Care

Karen Jacobson-Sive
Patients with myasthenia gravis (MG) largely expressed negative emotions around MG treatment and symptom burden in patient focus groups and on MG social media discussion boards.
Global health | Image Credit: © zephyr_p - stock.adobe.com
November 14th 2024

Worldwide Incidence, Prevalence of MG Has More Than Doubled Since 1950s

AJMC Contributor
The data come from a systematic review of over 90 studies between 1952 through 2022, which found that both prevalence and incidence rates have than doubled throughout the study period.
AI graphic | Image Credit: © NicoElNino-stock.adobe.com
November 8th 2024

Enhancing Myasthenia Gravis Care With AI-Powered Telemedicine

Kimberly Rath, PharmD
Researchers introduce a telemedicine system powered by artificial intelligence (AI) that automatically scores neuromuscular examinations, offering the potential to enhance patient monitoring, reduce variability in clinical trials, and improve access to care for neuromuscular disorders like myasthenia gravis.
Myasthenia gravis | Image Credit: © lexiconimages-stock.adobe.com
November 5th 2024

COVID-19 Exacerbations in Myasthenia Gravis Linked to Severity

Kimberly Rath, PharmD
This new study investigated the impact of COVID-19 on patients with myasthenia gravis, finding that although most patients did not experience severe COVID-19, a significant portion suffered postinfection exacerbations.
MG notes concept | image credit: Andrii - stock.adobe.com
October 23rd 2024

Rozanolixizumab Effective in Patients With MuSK MG, Analysis Shows

Jared Kaltwasser
A new subgroup analysis of patients with muscle-specific tyrosine kinase (MuSK) autoantibody-positive (Ab+) myasthenia gravis (MG) shows rozanolixizumab (Rystiggo) contributes to meaningful symptom improvement.
Colored Genetic Code DNA Molecule Structure | Image Credit: © ktsdesign - stock.adobe.com
October 16th 2024

Study Suggests Genetic Link Between HLA Alleles, MG

Gwen Mergian
Two genes were shown to be significantly associated with higher prevalence of myasthenia gravis (MG), a relatively rare autoimmune disease.
COVID-19 virus | Image credit: phonlamaiphoto - stock.adobe.com
October 6th 2024

Predictors of Poor Outcomes in Patients With Myasthenia Gravis and COVID-19

Kimberly Rath, PharmD
Researchers identify certain predictive factors that impact the prognosis of patients with myasthenia gravis and COVID-19 infection.
Thymus Gland | Image Credit: magicmine-stock.adobe.com
October 5th 2024

Small Study Shows Benefit With Minimally Invasive Thymectomy in MG

AJMC Contributor
Thoracoscopic thymectomy yielded quicker recovery time in myasthenia gravis (MG) while reducing disease severity, the need for treatment, and complications.
MG graphic | Image Credit: © Andrii-stock.adobe.com
October 2nd 2024

SC Efgartigimod Shows Noninferiority to IV Formulation in gMG

AJMC Contributor
The researchers have detailed their complete findings of subcutaneous (SC) vs intravenous (IV) efgartigimod in generalized myasthenia gravis (gMG) from the phase 3 ADAPT-SC trial and initial findings from the open-label extension of the study, ADAPT-SC+.
Statins may worsen myasthenic symptoms in MG | image credit: Ihphotos - stock.adobe.com
September 27th 2024

Statins Can Worsen MG Symptoms, but Cases Are Rare

Jared Kaltwasser
A study suggests most patients with myasthenia gravis (MG) can take statins without experiencing symptom worsening.
Myasthenia gravis | Image Credit: Andrii-stockk.adobe.com
September 24th 2024

Electrophysiology Aids Myasthenia Gravis, Related Disorders

Jared Kaltwasser
New research shows how repetitive nerve stimulation and single fiber electromyography can help diagnose disorders such as myasthenia gravis.
Image credit: luchschenF - stock.adobe.com
September 13th 2024

Researchers Characterize Distinct Biomarker Profile of AChR+ MG

AJMC Contributor
The potential value of these biomarkers may help differentiate acetylcholine receptor antibody seropositive (AChR+) myasthenia gravis (MG) from healthy patients.
A combination of infrared spectroscopy and AI could benefit the diagnosis of patients with MG | image credit: Tori Art - stock.adobe.com
September 6th 2024

Combining Infrared Spectroscopy, AI May Influence More Reliable Diagnosis of MG

AJMC Contributor
If integrated into clinical practice, the approach could fill a need for more optimal diagnostic approaches for myasthenia gravis (MG), explained the researchers.
New data make clear that there is a need for better diagnostic and disease-management strategies for myasthenia gravis. | Image credit: Николай Зотов - stock.adobe.com
August 31st 2024

Study: MG Diagnostic Delays Both Common and Harmful

Jared Kaltwasser
A survey of patients with myasthenia gravis in 5 European countries suggests patients wait on average about a year after symptom onset before they are given an accurate diagnosis.
Women typically experience more severe MG; however, this is not due to sex-based treatment differences | image credit: Wirestock - stock.adobe.com
August 24th 2024

No Sex-Based Differences Found in Treatment Timing in gMG

Gayle Turim Dickstein
A single-center cohort study found no differences between males and females in the odds of starting or time to treatment in generalized myasthenia gravis (gMG), but investigators want to continue to probe more deeply into why women are more severely affected by the disease.
concept of myasthenia gravis | Image Credit: syahrir-stock.adobe.com
August 17th 2024

Proximal Muscles Show Earlier RNS Response in MG, ALS

Karen Jacobson-Sive
The decremental response follows repetitive nerve stimulation (RNS) completed earlier in proximal muscles compared with distal muscles in a study of patients with myasthenia gravis (MG) and amyotrophic lateral sclerosis (ALS).
Patient in resp distress | Image Credit: New Africa-stock.adobe.com
August 13th 2024

Assessments Help Identify Patients With Myasthenia Gravis at Risk for Respiratory Distress

Karen Jacobson-Sive
A series of portable respiratory function tests for patients with mild to moderate myasthenia gravis (MG) were found to be useful methods to diagnose previously unidentified at-risk cases for respiratory deterioration.
Elderly patient lying in a hospital bed | Image credit: Soonthorn - stock.adobe.com
August 10th 2024

Pembrolizumab-Induced Overlap Syndrome: Case Report

Kimberly Rath, PharmD
A recent case report highlights the fatal risks of pembrolizumab, an immune checkpoint inhibitor, after an 87-year-old patient developed severe immune-related adverse events.
thymoma diagnosis | Image Credit: Vitalii Vodolazskyi-stock.adobe.com
August 7th 2024

Analysis Identifies Biomarkers in Thymoma-Associated MG

Jared Kaltwasser
The analysis represents an effort to use bioinformatics to find potential new therapeutic targets for myasthenia gravis (MG).
A woman consults with a doctor about myasthenia gravis symptoms. | Image credit: Chinnapong - stock.adobe.com
July 27th 2024

Analysis Supports Use of Newer PRO Scale in Myasthenia Gravis Trials

AJMC Contributor
A recent study showed that the Myasthenia Gravis (MG) Symptoms PRO scales viably measure core symptoms of the disease.
myasthenia gravis | Image Credit: Николай Зотов-stock.adobe.com
July 21st 2024

Chinese Patients With gMG Respond Well to Efgartigimod

Jared Kaltwasser
A new report offers safety and efficacy data on a population with generalized myasthenia gravis (gMG) not represented in the drug’s pivotal phase 3 trial.
Book about myasthenia gravis | Image Credit: mdaros-stock.adobe.com
July 16th 2024

Promising Results for Efgartigimod in Myasthenic Crisis

Kimberly Rath, PharmD
A new case report details the successful use of efgartigimod as a rescue medication in a patient with therapy-refractory myasthenic crisis.
Thymoma | Image Credit: Chris Titze Imaging - stock.adobe.com
July 11th 2024

Myasthenia Gravis: No Impact on Thymoma Outcome

Kimberly Rath, PharmD
A new study has found that myasthenia gravis does not affect the long-term prognosis of patients with thymoma.
Doctor speaking with patient | Image credit: Liudmila Dutko - stock.adobe.com
July 4th 2024

Treatment Patterns in Patients With Myasthenia Gravis Are Consistent Between US and Italy

Karen Jacobson-Sive
Patients with myasthenia gravis who received treatment within a year from diagnosis were generally in accordance with guideline suggestions.
Myasthenia gravis | Image Credit: © Andrii - stock.adobe.com
July 2nd 2024

Study Finds Ravulizumab Effective in Treating Acetylcholine Receptor–Positive Generalized MG

Karen Jacobson-Sive
More than 60% of complement inhibitor–naive patients with acetylcholine receptor–positive generalized myasthenia gravis (MG) in diverse clinical populations had a clinically meaningful reduction in MG activities of daily living scores.
A woman's vibrant hair dye may have triggered myasthenic crises, a case study found. | Image credit: LIGHTFIELD STUDIOS - stock.adobe.com
June 29th 2024

Case Study: Hair Dye Containing MIT Precipitates Myasthenic Crises

Gayle Turim Dickstein
A 43-year-old woman had 2 myasthenic crises within 3 months, with both taking place shortly after exposure to hair dye containing methylisothiazolinone (MIT).
Girl and female doctor | Image Credit: © Studio Romantic - stock.adobe.com
June 26th 2024

Thymectomy in Children With Myasthenia Gravis: An Option to Consider

Gayle Turim Dickstein
Results of a recent database analysis reveal that patients with juvenile myasthenia gravis—particularly prepubescent girls—might benefit from early thymectomy to cut production of autoreactive AChR B cells. Usually, though, it’s not done.
Teenage boy meeting with a doctor | Image credit: Monkey Business - stock.adobe.com
June 18th 2024

Eculizumab Shows Promising Results in Adolescents With Myasthenia Gravis

Kimberly Rath, PharmD
Study findings show eculizumab is effective and well tolerated in reducing disease burden in adolescents with refractory anti-acetylcholine receptor antibody–positive generalized myasthenia gravis.
Myasthenia gravis word photo | Image Credit: © Andrii - stock.adobe.com
June 12th 2024

Case Highlights Difficulties Identifying MG Secondary to ICI Therapy

Jared Kaltwasser
There currently are no guidelines on how to treat this patient group, despite a high risk of mortality.
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