Skin Cancer

The AJMC® Skin Cancer compendium is a comprehensive resource for clinical news and expert insights about melanoma and other skin cancers.

Latest News
July 1st 2025

Sun Exposure Risks Brought to Light During UV Safety Awareness Month

July 1st 2025

Challenges and Opportunities for AI in Melanoma Detection

June 25th 2025

Mitotic Rate, Lymphovascular Invasion Among Risk Factors for Relapse in Melanoma

June 18th 2025

Teledermatology Shows Promise to Reduce Disparities in Skin Cancer Screening

June 13th 2025

Cemiplimab Improves Disease-Free Survival in High-Risk, Advanced CSCC

Dr. Jason Luke leads a panel discussing immunotherapy advances in Cutaneous and Basal Cell Carcinoma

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Join a panel of leaders as they discuss treatment for patients diagnosed with metastatic NSCLC without driver mutations
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May 6th 2025

High UV Exposure Tied to Elevated Melanoma Risk in Large NIH-AARP Study: Samer Wahood, AB

December 5th 2022

Dr Neil Gross: Cemiplimab Has Great Potential in cSCC

November 12th 2022

Dr Neil Gross on Potential Impact of Future Novel Treatments for cSCC

November 2nd 2022

Dr Neil Gross Discusses the Implications of pCR on Additional Treatment in Skin Cancer

October 20th 2022

Dr Neil Gross: QOL Improvement Likely Following Treatment With Cemiplimab for cSCC

October 3rd 2022

Dr Neil Gross: Cemiplimab Is Producing Encouraging Results in Resectable cSCC

October 4th 2021

Dr Christine Ko on Making Tough Skin Cancer–Related Decisions for Transplant Patients

September 28th 2021

Dr Todd Schlesinger: Tissue-Sparing Mohs Surgery Is Highly Accurate

September 10th 2021

Dr Christine Ko: Transplant Patients Face Unique Skin Cancer Risks

September 5th 2021

Dr Todd Schlesinger on How Medical, Cosmetic, Research Dermatology Interact

Continuing Medical Education
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July 4th 2025

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology
July 4th 2025

Advancing Immunotherapy in Endometrial Cancer: A Managed Care Perspective on Personalized Care

1.5 Credits / Gynecologic Cancer, Health Equity, Diversity & Inclusion, Oncology, Women's Health

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The approval covers use of pembrolizumab as a single agent in the neoadjuvant setting, followed by adjuvant treatment with pembrolizumab in combination with radiotherapy with or without cisplatin after surgery, and then continued as a single agent. | Image credit: wladimir1804-stock.adobe.com
June 13th 2025

FDA Approves Perioperative Pembrolizumab in Resectable HNSCC

Jordyn Sava
The FDA has granted approval to pembrolizumab for the treatment of adult patients with resectable, locally advanced HNSCC whose tumors express PD-L1 with a CPS of ≥1.
The new report suggests the C5a-C5aRq axis might be a useful target in combination with existing therapies for cutaneous squamous cell carcinoma. | Image credit: vladimircaribb - stock.adobe.com
June 7th 2025

C5aR1 Flagged as Biomarker in Cutaneous Squamous Cell Carcinoma

Jared Kaltwasser
The findings are notable in part because therapies have already been approved to target C5aR1 in other diseases.
skin cancer screening doctor - Seventyfour - stock.adobe.com
May 21st 2025

Global Skin Cancer Burden Among Older Adults Surged Since 1990, Driven by Keratinocyte Cancer

Giuliana Grossi
New global analysis calls for urgent, targeted interventions as aging populations face rising rates of skin cancer.
Future validation studies with a larger sample size are warranted to ensure the technique will be useful in a clinical setting. | Image credit: Artur Wnorowski - stock.adobe.com
May 18th 2025

Novel, Noninvasive Skin Cancer Detection Method Shows Promise

Jared Kaltwasser
The tool could make it easier for clinicians to rule out melanoma without the need for excision.
While CTCs were identified regardless of disease stage, the current study identified large variations in the presence of CTCs between nonmetastatic and metastatic disease | Image Credit: Innovative Creation - stock.adobe.com
May 14th 2025

Flow Cytometry Can Reliably Identify CTC in Melanoma

AJMC Contributor
The study, which used flow cytometry rather than molecular biology to identify circulating tumor cells (CTCs), found a significant positive correlation between the number of CTCs and the stage of disease.
Offline data augmentation can significantly enhance deep learning techniques, improving classification performance compared to models trained solely on original clinician skin images. | Image Credit: Alexander - stock.adobe.com
May 12th 2025

Optimized Deep Learning Model Classifies Smartphone Images of Malignant Skin Lesions

AJMC Contributor
Across various classes, the researchers identified a model that, when coupled with appropriate data augmentation and optimization partner, may help aid in the detection of skin cancer.
The risk of recurrence was significantly higher for patients who were positive for ctDNA, whether they received a placebo or targeted therapy. | Image credit: vladimircaribb - stock.adobe.com
May 2nd 2025

ctDNA Monitoring Can Predict Early Melanoma Recurrence Following Resection

AJMC Contributor
Data come from patients with stage 3 melanoma enrolled in a phase 3 randomized trial and showed that detection of circulating tumor DNA (ctDNA) prior to adjuvant systemic therapy can predict risk of early recurrence.
Reconstruction following removal of nasal BCC is often required, even with soft tissue defects. | Image credit: Viktoriia - stock.adobe.com
April 28th 2025

Immediate Nasal Reconstruction Following BCC Removal Is Viable

AJMC Contributor
Immediate local flap or skin graft following basal cell carcinoma (BCC) can be considered, a study found.
Within 5 years, the risk of SCC in particular was heightened among patients with MMP. | Image credit: wavebreak3 - stock.adobe.com
April 21st 2025

Rare Autoimmune Disorder Linked With Increased Risk of Certain Skin Cancers

AJMC Contributor
The risk of some skin cancers, including squamous cell carcinoma, basal cell carcinoma, and non-melanoma skin cancer, was particularly heightened among patients with severe mucous membrane pemphigoid.
Patients who stopped adjuvant immunotherapy less than 12 months following metastatic melanoma resection did not experience inferior outcomes. | anna.stasiia - stock.adobe.com
April 17th 2025

Early Adjuvant Immunotherapy Discontinuation Does Not Affect Melanoma Recurrence Risk

Jared Kaltwasser
Recurrence-free survival rates were similar, even when patients quit adjuvant immunotherapy early, according to a new report.
Patient self reporting or intentional physical examinations by clinicians remain the main avenues by which suspected skin cancers are identified. | Image credit: anna.stasiia - stock.adobe.com
April 10th 2025

Novel Methods Could Reshape Skin Cancer Diagnostics

Jared Kaltwasser
Investigators highlighted Raman spectroscopy, a noninvasive diagnostic technology that could lead to faster, earlier detection of skin cancer.
Woman with keloid on shoulder | Image credit: weerajata – stock.adobe.com
April 2nd 2025

Deep Learning Tool Differentiates Keloids From Malignant Lesions Without Dermoscopy

Hayden E. Klein
After fine-tuning, the VGG16 convolutional neural network outperformed other deep learning models in 2 of 3 key classification tasks.
Estrogen | Image credit: Debalina - stock.adobe.com
March 20th 2025

Estrogen Therapy May Increase Risk of 3 Skin Cancers

Hayden E. Klein
Researchers of a Swedish study advise physicians to consult with their patients about these risks and take extra precautions, but did not recommend discontinuation of any of the drugs studied.
Doctor screening patient for skin cancer | Image credit: Seventyfour – stock.adobe.com
March 14th 2025

Patients Prefer AI in Skin Cancer Screening as an Assistive Tool, Not a Replacement

Hayden E. Klein
Patients expressed concern that overreliance on artificial intelligence (AI) could lead to clinicians losing their skills, both medical and interpersonal.
Report Highlights Role of Cancer-Associated Fibroblasts in Melanoma Metastases
March 13th 2025

Report Highlights Role of Cancer-Associated Fibroblasts in Melanoma Metastases

Jared Kaltwasser
The study could open the door to potential novel therapeutic targets.
Newer technology may play an important role in aiding early skin cancer diagnosis, new research suggests. | Image credit: InsideCreativeHouse - stock.adobe.com
March 11th 2025

AI, Other Technologies May Help Narrow Gender Disparities in Melanoma

Jared Kaltwasser
Men with melanoma tend to be diagnosed later and have worse outcomes. Artificial intelligence can help change that, a review suggests.
Doctor conducting a skin cancer check | Image credit: InsideCreativeHouse - stock.adobe.com
March 6th 2025

Image-Guided Superficial Radiation Therapy Safe, Effective Treatment for Nonmelanoma Skin Cancer: Expert Panel

Emma Andrus
A dermatology expert panel confirms image-guided superficial radiation therapy as a safe, effective first-line treatment for select nonmelanoma skin cancer cases.
Older man after skin cancer surgery with bandage on face | Image credit: steheap – stock.adobe.com
February 7th 2025

Keratinocyte Skin Cancer Surgery Considered Safe, Effective in Older Patients

Hayden E. Klein
A single-center study suggests the surgery is safe and effective even when tumors are large or located in high-risk areas.
Dermatologist examining skin | Image credit: Medical Works – stock.adobe.com
January 20th 2025

Combination Immunotherapy Offers New Pathway for Skin Cancer Prevention

Alexandra Gerlach
A topical treatment combining calcipotriol and 5-FU shows promise in reducing premalignant lesions and lowering skin cancer risk by activating Th2 immunity.
Doctor inspecting skin cancer | Image credit: InsideCreativeHouse – stock.adobe.com
January 17th 2025

Adjuvant Cemiplimab Significantly Improves Disease-Free Survival in High-Risk Skin Cancer

Hayden E. Klein
Cemiplimab significantly reduced the risk of recurrence or death in patients with high-risk cutaneous squamous cell carcinoma (CSCC) post-surgery.
AI-generated image of a pill saying metformin | Image credit: Giama22 – stock.adobe.com
January 15th 2025

Diabetes Drug Metformin May Have Another Use: Protecting Against Skin Cancer

Hayden E. Klein
However, metformin did not protect Black patients against squamous cell carcinoma specifically.
Skin cancer | Image credit: anna.stasiia – stock.adobe.com
January 11th 2025

Skin Cancer Disparities Persist in Latine/Hispanic Population

Hayden E. Klein
Latine individuals in the US face higher morbidity and mortality in skin cancer outcomes despite lower lifetime risk.
Advancing health equity can be achieved through community engagement | image credit: Andrii - stock.adobe.com
October 16th 2024

Community Engagement, Culturally Tailored Care as a Gateway to Advancing Health Equity

Kyle Munz
Many talks at the Association of Cancer Care Centers (ACCC) 41st National Oncology Conference advocated for the adoption of culturally relevant care, the leveraging of community partnerships, and community engagement to build better trust with patients and improve outcomes.
Biofrontera's red-light LED has been approved for the treatment of actinic keratosis | image credit: marog-pixcells - stock.adobe.com
June 28th 2024

FDA-Approved Red-Light LED Lamp Released for Patients With Actinic Keratosis

Tim Smith
The announcement followed the release of the RhodoLED XL red light-emitting lamp, to be used in combination with aminolevulinic acid hydrochloride topical gel, 10% for actinic keratoses.
skin cancer | Image Credit: uffoow-stock.adobe.com
June 28th 2024

Certain Melanoma Subtype May Be More Sensitive to NK, T Cells

AJMC Contributor
Of 7 subtypes identified 10,000 melanoma cells, C4 Melanoma COCO1A was the only to show indications of being more sensitive to natural killer (NK) and T cells.
Medicaid coverage | image credit: nelzajamal - stock.adobe.com
June 20th 2024

Further Medicaid Expansion Would Benefit Patients With Melanoma, Study Finds

Kyle Munz
A poster presented at the 2024 American Society of Clinical Oncology annual meeting argued the benefits that Medicaid expansion can bring to patients with melanoma.
Pregnancy-associated melanoma is a rare occurence that impacts 1 in 2200 pregnancies | image credit: Alik Mulikov - stock.adobe.com
June 15th 2024

Management of Melanoma During Pregnancy Explored at ASCO 2024

Kyle Munz
Two posters presented at the 2024 American Society of Clinical Oncology annual meeting revealed real-world data on the outcomes and management strategies associated with melanoma during pregnancy.
Skin cancer risk may be associated with immunosuppressant medication, although multiple studies exploring this relationship have not drawn concrete conclusions | image credit: Damian Gretka - stock.adobe.com
June 13th 2024

Link Between Skin Cancer and Immunosuppressants Needs Further Research

Kyle Munz
At the 2024 American Society of Clinical Oncology annual meeting, an abstract presenting real-world data stressed the need for further research regarding the association between immunosuppressant medication and the development of skin cancer.
Skin cancer checkup concept with cancer ribbon | image credit: Monstar Studio - stock.adobe.com
June 10th 2024

Metformin for Melanoma Holds Potential Benefits for Patients

Kyle Munz
Metformin showed promise for improving the overall survival rate of patients with melanoma; however, this result may be an indirect consequence of the drug.
Skin cancer screening | Image credit: Viktoriia - stock.adobe.com
May 31st 2024

Keratinocyte Cancers Most Commonly Located on the Head and Neck, US Study Finds

Rose McNulty
A large Medicare cohort study found that the most common locations of procedurally treated keratinocyte cancers in the US were the head and/or neck for both squamous cell carcinomas and basal cell carcinomas.
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