MDM2 Antagonists Help CDK4/6 Inhibitors Overcome Resistance in Melanoma
August 21st 2019Outside of breast cancer, cyclin-dependent kinases 4 and 6 (CDK4/6) inhibitors have not been as successful as tumors develop resistance. New research shows that a murine double minute (MDM2) antagonist can help CDK4/6 inhibitors overcome resistance, offering a potential second-line treatment option in melanoma.
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Changing Demographics Among Populations Prescribed HCV Treatment, 2013-2017
From 2013 to 2017, the population of US patients prescribed treatment for chronic hepatitis C virus (HCV) changed, becoming predominantly treatment-naïve and having received care in nonacademic centers.
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Understanding Price Growth in the Market for Targeted Oncology Therapies
The prices of targeted oncology therapies have grown substantially, but revenues have not. This is due in part to large declines in per-drug patient counts.
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Beyond Satisfaction Scores: Exploring Emotionally Adverse Patient Experiences
This study explores the causes of emotionally adverse patient experiences in cancer care and presents a taxonomy for analyzing free-text patient data.
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Effect of Changing COPD Triple-Therapy Inhaler Combinations on COPD Symptoms
April 10th 2019Changing patients from an inhaled corticosteroid (ICS)/long-acting β agonist (LABA) inhaler and long-acting muscarinic agonist (LAMA) inhaler to a LAMA/LABA inhaler and a separate ICS inhaler did not appear to affect patient-reported chronic obstructive pulmonary disease (COPD) symptom scores.
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