BRVO, CRVO Need More Effective Long-term Therapies
February 12th 2023While the current therapies are effective for treating branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO), they are inadequate for long-term treatment in clinical practice, according to an analysis of real-world data.
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High-Dose Aflibercept in Wet AMD and DME Provides Therapeutic Benefits, No New Safety Signals
February 12th 2023Two studies looking at a higher dose of aflibercept found that an 8-mg dose can be maintained at longer dosing intervals with similar benefits and no additional safety signals compared with the 2-mg dose.
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Home OCT: Providing More Personalized, Timely Treatment for Wet AMD
February 11th 2023Home optical coherence tomography (OCT) has shown there is a wide degree of heterogeneity in fluid dynamics and treatment response that may not be clear during regular office visits and scans. Presenters reviewed the latest data in home OCT to manage wet age-related macular degeneration (AMD).
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Mitochondrial Stabilizing Drugs Have Potential to Reverse Vision Loss in Dry AMD
February 10th 2023A review of data on 2 mitochondrial membrane stabilizers—risuteganib and elamipretide—has highlighted the potential to not just slow disease progression but actually reverse vision loss in patients with intermediate dry age-related macular degeneration (AMD).
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Improved Implementation Strategies Can Further Advance SMA Care, Researchers Say
January 7th 2023The diagnosis and treatment of a rare disease like spinal muscular atrophy (SMA) would benefit greatly from using implementation science to reduce the variation that exists in screening and therapy, according to researchers.
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Individual clinicians can lead efforts to build trust in science and distribute accurate information, but medical schools also have an important role to play in training health care professionals to communicate with the public, according to Vineet Arora, MD, MAPP, dean for medical education at UChicago Medicine.
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Flight Home From Pharmacy Conference Holds More Surprises With Medical Emergency
December 9th 2022As they headed home Thursday from the 2022 American Society of Health-System Pharmacists (ASHP) Midyear Clinical Meeting & Exhibition in Las Vegas, pharmacists pitched in to help a man having a medical emergency aboard a United flight bound for Newark, New Jersey.
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What Predicts Good Outcomes With Axi-cel? Investigators Support “Timely” Treatment
December 3rd 2022Investigators from Fred Hutchison Cancer Research Center hoped to gain insights into what factors can predict success with axi-cel in patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL).
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Dr Vineet Arora Discusses Policy, Equity Goals in Approach to Medical Education
November 25th 2022As dean for medical education at the University of Chicago, Vineet Arora, MD, MAPP, takes a longitudinal view of the training pathway with an eye toward equity in opportunity and system-level improvement of processes.
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California Takes a Step Toward Bringing Equity in Cancer Care
October 22nd 2022The new law will expand access for Medi-Cal patients who receive a complex cancer diagnosis and represents a critical first step in fulfilling the promise of the California Cancer Patients Bill of Rights, a resolution adopted by the legislature in 2021.
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Childhood Trauma Not a Barrier to Successful Depression Treatment, Analysis Finds
September 22nd 2022Prior research has suggested that childhood trauma is linked with a poorer response to psychotherapy and prescription drug treatment for major depressive disorder, but a large meta-analysis suggested otherwise.
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Dr Vivienne Hau: Without Representation, Clinical Trials Cannot Adequately Judge Drug Effectiveness
September 6th 2022Different populations respond differently to drugs and treatments, but without adequate representation in clinical trials, it will be hard to judge the effectiveness of a new treatment, explained Vivienne Hau, MD, clinical assistant professor with the Kaiser Permanente Bernard J. Tyson School of Medicine.
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Success in Eosinophil-Targeted Treatments for EoE Remains Limited
September 2nd 2022The researchers compiled data from studies of lirentelimab, mepolizumab, reslizumab, and benralizumab, highlighting the difficulties in finding an effective approach with eosinophil-targeted treatments for eosinophilic esophagitis (EoE).
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Patients and Parents Impacted by SMA May Be Optimistic About Prenatal Testing, Therapies
September 2nd 2022As the feasibility of phase 1 clinical trials for prenatal spinal muscular atrophy (SMA) therapies is explored, patient and parent input on prenatal testing and possibly treatment is a valuable tool for guiding research discussions.
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What We're Reading: Drug Pricing Debate; Judge Rules Against Walgreens; Predicting TBI Outcomes
August 11th 2022Policy observers and industry stakeholders debate the possible spillover effects of Medicare drug pricing reform in the employer-based insurance market; a California federal judge rules Walgreens could be held liable for not investigating suspicious orders of opioids in San Francisco; a blood test performed the day of a traumatic brain injury (TBI) can predict which patients may die and who may survive with a disability.
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Topline KarMMa-3 Results for Ide-Cel in Multiple Myleoma Show “Significant Improvement” in PFS
August 10th 2022Ide-cel is a B-cell maturation antigen (BCMA)-directed CAR T-cell therapy, which uses the process of genetically modifying a patient’s T cells and infusing them back into the patient to attack the cancer.
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