Parkinson Disease

The AJMC® Parkinson Disease compendium is a comprehensive resource for clinical news and expert insights for progressive nervous system disorder, which affects movement and often includes tremors.

Latest News

Air Pollution Linked to PD, With Mississippi-Ohio River Valley Region Most Affected
Air Pollution Linked to PD, With Some Parts of US More Affected Than Others

February 24th 2023

The latest research to look at the links between Parkinson disease and air pollution said the Rocky Mountain region and the Mississippi-Ohio River Valley appeared to be the most affected.

PD Worsens QOL, Increases Depression in Men More Than Women in the Southeast
PD Worsens QOL, Increases Depression in Men More Than Women in the Southeast

February 17th 2023

Image of a diverse group of patients
Certain Patient Groups Continue to Be Underrepresented in PD Studies in the Netherlands

February 4th 2023

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Creating a Metric to Determine Social Functioning in Parkinson Disease

February 1st 2023

Woman in meditation position
Mindfulness Training May Improve Outcomes for People With Parkinson Disease

January 30th 2023

More News

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October 13th 2020

Exploring the Clinical Burden of OFF Periods in Parkinson Disease

Caroline M. Tanner, MD, PhD
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October 13th 2020

The Economic Impact of OFF Periods in Parkinson Disease

Iresha Abeynayake, MPH Caroline M. Tanner, MD, PhD
Examining Chronic Pain in Parkinson Disease
October 6th 2020

Examining Chronic Pain in Parkinson Disease

Matthew Gavidia
Researchers examine the clinical and pathophysiological mechanisms underlying pain in Parkinson disease.
Spinal Cord Stimulation Found to Reduce Pain, Motor Symptoms in Parkinson Disease
October 3rd 2020

Spinal Cord Stimulation Found to Reduce Pain, Motor Symptoms in Parkinson Disease

Matthew Gavidia
Spinal cord stimulation was found to decrease pain and reduce motor symptoms of Parkinson disease as both a singular therapy and as a salvage therapy after deep brain stimulation therapies proved ineffective.
Novel Study Examines Optimal Drug Balance for Patients With Parkinson Disease
September 29th 2020

Novel Study Examines Optimal Drug Balance for Patients With Parkinson Disease

Matthew Gavidia
Researchers assess the optimal balance of levodopa in patients with Parkinson disease (PD), which wanes in efficacy as PD progresses and can contribute to uncontrollable, involuntary bodily movements if given in too high of a dosage.
Access to Parkinson Disease Medication Affected in Low-Income Countries
September 23rd 2020

Access to Parkinson Disease Medication Affected in Low-Income Countries

Matthew Gavidia
Amid the COVID-19 pandemic, health professionals reported difficulty accessing Parkinson disease medications, particularly in low-income countries, leading to greater disability of patients as a result.
Novel Screening Approach May Help Track Progression of Parkinson Disease
September 21st 2020

Novel Screening Approach May Help Track Progression of Parkinson Disease

Matthew Gavidia
Researchers present a novel approach to identifying molecules associated with the progression of Parkinson disease and other neurodegenerative diseases.
Blood Pressure Linked With Fall Risk in Patients With Parkinson Disease
September 17th 2020

Blood Pressure Linked With Fall Risk in Patients With Parkinson Disease

Matthew Gavidia
People with Parkinson disease (PD) were found to be more likely than those without the condition to have orthostatic hypotension, a sudden drop in blood pressure upon standing that can exacerbate the risk of falling.
Assessing Immunotherapies Targeting α-Synuclein in Parkinson Disease
September 14th 2020

Assessing Immunotherapies Targeting α-Synuclein in Parkinson Disease

Matthew Gavidia
A review discusses what immunotherapies are currently being evaluated to target α-synuclein, an abnormal protein suggested to have a central role in the pathogenesis of PD.
Review Associates Exercise With Improved Quality of Life, Immune Response in Parkinson Disease
September 11th 2020

Review Associates Exercise With Improved Quality of Life, Immune Response in Parkinson Disease

Matthew Gavidia
Exercise was identified as a potential intervention to improve quality of life and heighten immune response among patients with Parkinson disease.
Combination Therapy Shown to Improve Sleep Disturbance in Patients With Parkinson Disease
September 9th 2020

Combination Therapy Shown to Improve Sleep Disturbance in Patients With Parkinson Disease

Matthew Gavidia
Among patients with advanced Parkinson disease and motor fluctuations, a combination of levodopa/carbidopa/entacapone was shown to improve motor and sleep symptoms.
Can Diet Reduce Risk of Parkinson Disease?
September 4th 2020

Can Diet Reduce Risk of Parkinson Disease?

Matthew Gavidia
A healthy diet consisting of fruit, vegetables, and whole grains in middle age may be associated with fewer non-motor symptoms known to precede the diagnosis of Parkinson disease, according to study findings.
Short-term Integrated Palliative Care Reduces Costs for Patients With Long-term Neurological Conditions
August 31st 2020

Short-term Integrated Palliative Care Reduces Costs for Patients With Long-term Neurological Conditions

Matthew Gavidia
There was no statistically significant difference in patient-reported outcomes for short-term integrated palliative care compared with standard care in those with long-term neurological conditions.
Managing Comorbid Parkinson Disease, Diabetes
August 27th 2020

Managing Comorbid Parkinson Disease, Diabetes

Matthew Gavidia
Researchers explore the standard pathophysiological and molecular linkages between Parkinson disease (PD) and diabetes, as well as the role of diabetes therapies in the pathological pathways and progression of PD.
Dementia, Hypertension Linked to COVID-19 Mortality in Parkinson Disease
August 25th 2020

Dementia, Hypertension Linked to COVID-19 Mortality in Parkinson Disease

Matthew Gavidia
Among patients with Parkinson disease (PD), co-occurrence of dementia and hypertension, as well as duration of PD, were significantly associated with mortality due to coronavirus disease 2019 (COVID-19), according to a recent study.
What Benefits Can Dietary Management Provide Patients With Parkinson Disease?
August 22nd 2020

What Benefits Can Dietary Management Provide Patients With Parkinson Disease?

Matthew Gavidia
Researchers find that monitoring dietary intake in patients with Parkinson disease (PD) could detect possible micronutrient insufficiencies that may exacerbate adverse effects such as constipation. Expanding knowledge on correct medication intake among patients with PD was also cited.
Switching Off Influential Enzyme May Shield Brain From Parkinson-Related Damage
August 21st 2020

Switching Off Influential Enzyme May Shield Brain From Parkinson-Related Damage

Matthew Gavidia
Switching off a “master regulator” of the epigenome called TET2 may protect the brain from the inflammatory damage and neurodegeneration caused by Parkinson disease, according to recent study findings.
Novel Drug Shown to Improve Gastrointestinal Dysfunction in Patients With Parkinson Disease
August 14th 2020

Novel Drug Shown to Improve Gastrointestinal Dysfunction in Patients With Parkinson Disease

Matthew Gavidia
DA-9701 therapy was found to improve the severity of gastrointestinal symptom–related quality of life and severity in patients with Parkinson disease, with no adverse effects on motor symptoms, according to study findings.
Can Deep Brain Stimulation Improve Social, Occupational Functioning in Patients With Parkinson Disease?
August 11th 2020

Can Deep Brain Stimulation Improve Social, Occupational Functioning in Patients With Parkinson Disease?

Matthew Gavidia
Among patients with Parkinson disease aged 60 years and younger with early motor complications, deep brain stimulation was found to provide significant improvements in social, occupational, and psychosocial function.
What Obstacles Are Impeding Early Diagnosis of Parkinson Disease?
August 6th 2020

What Obstacles Are Impeding Early Diagnosis of Parkinson Disease?

Matthew Gavidia
Improving on the ability to confirm diagnosis of Parkinson disease (PD) earlier and determining who is at risk for PD were referenced as key factors in further slowing progression of the disease, according to review findings.
What Emerging Drug Therapies Are in the Clinical Trial Pipeline for Parkinson Disease?
August 3rd 2020

What Emerging Drug Therapies Are in the Clinical Trial Pipeline for Parkinson Disease?

Matthew Gavidia
Overall, there are 145 registered and ongoing clinical trials for therapies targeting Parkinson disease, of which 28 are currently in phase 3, according to review findings.
Review Discusses Physical Impact of Nonmotor Symptoms in Parkinson Disease
July 30th 2020

Review Discusses Physical Impact of Nonmotor Symptoms in Parkinson Disease

Matthew Gavidia
Researchers discuss the implications of nonmotor symptoms in patients with Parkinson disease, which can contribute to major sleep, ocular, olfactory, throat, cardiovascular, gastrointestinal, genitourinary, or musculoskeletal disorders.
Concussion Associated With Greater Risk of Parkinson Disease, Dementia
July 28th 2020

Concussion Associated With Greater Risk of Parkinson Disease, Dementia

Matthew Gavidia
Individuals who had experienced a concussion were found to be at a greater risk of Parkinson disease, mood and anxiety disorders (MADs), dementia, and hyperactivity disorder, with concussed women indicated as a notable at-risk population for MADs, according to study findings published today.
What Are the Implications of OFF Periods, Economic Burden in Parkinson Disease?
July 24th 2020

What Are the Implications of OFF Periods, Economic Burden in Parkinson Disease?

Matthew Gavidia
A recent webinar discussed what causes symptom recurrence in patients with Parkinson disease and what implications this has for health outcomes and health care cost.
Vision Issues in Patients With Parkinson Disease Linked With Behavioral, Cognitive Impairment
July 17th 2020

Vision Issues in Patients With Parkinson Disease Linked With Behavioral, Cognitive Impairment

Matthew Gavidia
Patients with Parkinson disease who experience visual impairment were found to be more prone to behavioral issues such as depression and anxiety, as well as dementia and death, according to study findings.
What Can Improve On-Time Administration of Parkinson Disease Medications?
July 14th 2020

What Can Improve On-Time Administration of Parkinson Disease Medications?

Matthew Gavidia
A quality improvement project led by a multidisciplinary team was found to significantly improve on-time administration of levodopa and other medications for patients with Parkinson disease, according to study findings.
Study Suggests Deep Brain Stimulation Does Not Increase Risk of Dementia in Patients With Parkinson Disease
July 10th 2020

Study Suggests Deep Brain Stimulation Does Not Increase Risk of Dementia in Patients With Parkinson Disease

Matthew Gavidia
In patients with Parkinson disease (PD) who underwent deep brain stimulation, dementia prevalence and incidence were not found to be higher than those in the general PD population, according to study findings.
What Are Common Catalysts of Early Morning OFF Periods in Patients With Parkinson Disease?
July 6th 2020

What Are Common Catalysts of Early Morning OFF Periods in Patients With Parkinson Disease?

Matthew Gavidia
Seven symptoms were identified as most predictive of early morning OFF periods (EMO) in patients with Parkinson disease, which may assist in understanding and managing potential determinants and negative health effects of EMO.
Alexithymia Linked With Reduced QOL, Increased Caregiver Burden in Parkinson Disease
July 3rd 2020

Alexithymia Linked With Reduced QOL, Increased Caregiver Burden in Parkinson Disease

Matthew Gavidia
Health-related quality of life and caregiver burden were both significantly correlated with alexithymia in patients with Parkinson disease, with the sub-component “identifying feelings” serving as a key factor.
Can Progression of Parkinson Disease Be Slowed?
July 1st 2020

Can Progression of Parkinson Disease Be Slowed?

Matthew Gavidia
Deep brain stimulation (DBS) implanted in early-stage Parkinson disease (PD) was found to decrease the risk of disease progression. If findings are replicated in a larger trial recently approved by the FDA, DBS would be the first therapy proven to slow the progression of any element in PD.
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