Opinion|Videos|July 16, 2024

Updates in Recent Clinical Trials in the Treatment of Multiple Sclerosis

Medical experts discuss the failure of evobrutinib to meet its primary endpoint in phase 3 trials, review the primary outcomes of the phase 2B study of tolebrutinib in relapsing multiple sclerosis, examine payers' perspectives on the currently available data for tolebrutinib, and briefly describe the design of the HERCULES trial.

Video content above is prompted by the following questions:

  • Evobrutinib did not meet its primary endpoint in phase 3 trials. Were you surprised by these results?
  • What were the primary outcomes of the phase 2B study of tolebrutinib in relapsing multiple sclerosis?
    • What was seen in the 3-year data?
    • How do payers view the currently available data of tolebrutinib?
  • Tolebrutinib is also under investigation in non-relapsing secondary progressive multiple sclerosis. Why is there a need to investigate therapies in this phenotype and what is the phase 3 HERCULES trial design?

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