Optimizing BTKi Treatment Strategies

EP: 1.Clinical Characteristics Distinguishing CLL and SLL

EP: 2.Quality of Life Impacted By CLL and SLL Diagnosis and Management

EP: 3.Evaluating Current Treatment Landscape of CLL and SLL

EP: 4.Unmet Needs In CLL and SLL Treatment Management

EP: 5.Indications and Considerations For BTK Inhibitor Use In CLL and SLL Management

EP: 6.Examining Safety and Efficacy of BTK Inhibitors In CLL and SLL Treatment

EP: 7.Determining Optimal CLL / SLL Therapy: Ibrutinib, Acalabrutinib and Zanubrutinib

EP: 8.Key Highlights From ASH 2023

EP: 9.Economic Burden Associated With BTK Inhibitor Use

EP: 10.Patient Education Driving BTK Inhibitor Treatment Adherence

Now Viewing

EP: 11.Optimizing BTKi Treatment Strategies

EP: 12.Key Considerations for Treating Patients Diagnosed With CLL and SLL

This is a video synopsis/summary of a Peer Exchange involving: Ryan Haumschild, PharmD, MS, MBA, CPEL; Tara Graff, DO, MS; Ryan Jacobs, MD; Deborah Stephens, DO; Jennifer Woyach, MD.

The group discusses anticipated advancements in Bruton tyrosine kinase inhibitor (BTKi) therapy for chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). A key goal is converting continuous BTKi treatment into time-limited approaches through combinations or stopping criteria based on deep responses. This could improve quality of life and reduce financial burdens compared with indefinite therapy.Incorporating assessment of minimal residual disease as a trigger for discontinuation is an exciting strategy being explored in trials.

The panelists highlight the potential of leveraging precision medicine through mutational profiling and cytogenetics to guide upfront BTKi selection and sequencing. This allows customization based on a patient’s molecular features rather than a one-size-fits-all approach. Expanding the options for noncovalent BTKis that can overcome specific resistance mutations will enable optimal treatment sequencing tailored to a patient’s mutational profile when disease relapse occurs.

Overall, the group is optimistic about integrating predictive biomarkers, combination strategies, and novel targeted agents to usher in an era of personalized BTKi therapy in CLL and SLL. This offers hope for maximizing treatment outcomes while minimizing toxicity burdens for patients.

Video synopsis is AI-generated and reviewed by AJMC® editorial staff.