Introducing Bispecifics for Extensive-Stage SCLC

Author(s):

Ryan Haumschild, PharmD, MS, MBAAnne Chiang, MD, PhD

Panelists discuss how tarlatamab, a bispecific T-cell engager therapy, received accelerated approval for extensive-stage small cell lung cancer (SCLC) in May 2024, examining its mechanism of action, pivotal clinical data, management of adverse events, practical considerations for administration, and its position within the SCLC treatment algorithm.

EP: 1.Introduction: Risk Factors and Characteristics Defining SCLC

EP: 2.Established Multidisciplinary Therapies for SCLC

EP: 3.Immunotherapies for Extensive-Stage SCLC

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EP: 4.Introducing Bispecifics for Extensive-Stage SCLC

Tarlatamab was given accelerated approval in May 2024 for extensive-stage small cell lung cancer (SCLC). How does this therapy work, and what was the important data the led to its approval?

What are the main adverse events to watch for, and do you manage them?
Are there any other clinical considerations, such as inpatient or outpatient dosing, when using a bispecific T-cell engager like tarlatamab?
Where does this therapy fit into your treatment algorithm for patients with SCLC?