Opinion
Video
Immunotherapies for Extensive-Stage SCLC
Author(s):
Panelists discuss how immunotherapies like durvalumab and atezolizumab have emerged as promising treatments for extensive-stage small cell lung cancer (SCLC), complementing traditional chemotherapy, and explore the results of key trials such as CASPIAN and IMpower133 while considering patient selection, treatment algorithms, and management of adverse events associated with these novel therapies.
Let’s discuss the extensive-stage setting first. Beyond chemotherapy, immunotherapies have also been investigated in small cell lung cancer (SCLC). What are the main differences between these 2 classes of medication, and why was it necessary to study these in SCLC?
Durvalumab has also shown to have positive results as a first-line treatment in extensive-stage lung cancer in the CASPIAN trial. Where does this treatment fit into your treatment algorithm?
- What are the adverse events to monitor for, and how do you manage them?
Can you describe the results of the IMpower133 trial with atezolizumab in extensive-stage SCLC and how these impact your practice?
- In which patients do you use atezolizumab?
