Treating PNH: Understanding Complement Inhibitors, Modes of Administration, and Coordinated Patient Care Needs

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In this AJMC peer exchange program, Dr. Ryan Haumschild and a panel of experts, including Dr. Jamie Koprivnikar, Dr. Brian Mulherin, and Dr. David Dingli, discuss Paroxysmal Nocturnal Hemoglobinuria (PNH), focusing on its pathophysiology, complement inhibitors, treatment strategies, and the challenges of managing this rare, life-threatening disorder.

Episodes

June 4th 2024EP. 1: PNH Overview and Pathophysiology

Dr. Haumschild drives a discussion providing an overview of PNH and pathology of the disease.

June 4th 2024EP. 2: Intravascular and Extravascular Hemolysis MoA in PNH

Medical experts illustrate the nature of hemolysis in PNH and characteristics unique to the disease state.

June 11th 2024EP. 3: Utilizing Health Information Technology to Bridge Gaps in PNH Treatment Programming

Key opinion leaders navigate barriers to optimal care for patients receiving treatment for PNH.

June 11th 2024EP. 4: Key Treatment Considerations for Patients Diagnosed With PNH

Dr Haumschild drives a discussion surrounding impactful PNH treatment strategies.

June 19th 2024EP. 5: Complement System Role in PNH Treatment Approach

Dr Haumschild continues leading a discussion surrounding management of PNH, emphasizing the impact of complement inhibitors.

June 19th 2024EP. 6: Eculizumab Impact on PNH Treatment Landscape and Unmet Needs in PNH Management

Medical experts highlight unmet needs in the PNH treatment landscape and considerations for utilizing eculizumab.

June 26th 2024EP. 7: Efficacy End Points For PNH Treatment

Dr Haumschild continues leading an expert discussion surrounding key strategies and pain points in PNH treatment.

June 26th 2024EP. 8: Efficacy and Safety Trials Results of Complement Inhibitors

Expert panelists evaluate results regarding complement inhibitor trials for utilization in PNH management.

July 3rd 2024EP. 9: Treatment Adherence and Cost Considerations Surrounding Various Routes of PNH Treatment Administration

Economic impacts on patients receiving treatment for PNH and a conversation surrounding treatment adherence are discussed by key opinion leaders.

July 3rd 2024EP. 10: Investigational Therapies Paving New PNH Treatment Pathways

Dr Haumschild continues leading a discussion surrounding potential treatment advancements in the PNH landscape.

July 10th 2024EP. 11: Key Financial Factors Associated With Typical PNH Treatment Journey

Dr Haumschild and a panel of medical experts underscore financial considerations in PNH treatment.

July 10th 2024EP. 12: Navigating Transfusion Requirements in PNH Treatment

Key considerations for transfusion requirements in patients with PNH are discussed by key opinion leaders.

July 17th 2024EP. 13: Considerations for Managing PNH Treatment Complications

Medical experts navigate significant challenges associated with PNH treatment.

July 17th 2024EP. 14: Infection Risk Management Counseling For Patients Receiving Treatment for PNH

Key discussion points for educating patients on infection risk management in PNH care are highlighted.

July 24th 2024EP. 15: Ensuring PNH Treatment Access and Adherence to Therapies

Ryan Haumschild, PharmD, MS, MBA;Jamie L. Koprivnikar, MD;David Dingli, MD, PhD;Brian P. Mulherin, MD

Barriers to care and treatment adherence for patients diagnosed with PNH is discussed.

July 24th 2024EP. 16: Financial Considerations Influencing Treatment Strategies in PNH Treatment Pathway

Ryan Haumschild, PharmD, MS, MBA;Jamie L. Koprivnikar, MD;David Dingli, MD, PhD;Brian P. Mulherin, MD

The panelists provide their final thoughts, highlighting financial considerations in PNH treatment.

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