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This case study, involving a boy aged 13 years, shows that in a little over 1 year, the treatment yielded significant clinical benefit.

After a 12-month follow-up of patients in the CHAMP-HF registry, Kansas City Cardiomyopathy Questionnaire Overall Summary Score (KCCQ-OS) was shown to be more prognostically accurate compared with New York Heart Association functional class.

AstraZeneca releases updated efficacy data for its COVID-19 vaccine following scrutiny; Rachel Levine, MD, is confirmed as the first openly transgender person to serve in a federal position; hundreds of migrant children remain in isolation after testing positive for COVID-19.

Twice weekly high doses of carfilzomib in combination with lenalidomide and dexamethasone was tolerable and effective among patients with newly diagnosed multiple myeloma.

More than two-thirds of patients with chronic lymphocytic leukemia (CLL) survived at least 2 years but were highly susceptible to adverse events (AEs), in a recent study.

Reviewing available literature on the implications of oral health in people with Parkinson disease, researchers found reduced rates of oral hygiene and high prevalence of mostly preventable oral conditions, such as tooth decay and receding gums.

With many patients with multiple sclerosis (MS) increasingly turning to herbal drugs and supplements to treat their disease, for which there is no cure, a recent review evaluated the safety of these alternative therapies.

Updates to the NCCN Guidelines in multiple myeloma reflect recent trial results, giving clinicians and patients many choices.

Draft legislation details European Union (EU) plans to cut back its COVID-19 vaccine exports; the Biden administration announces a 3-month extension to Affordable Care Act (ACA) open enrollment; Johnson & Johnson (J&J) may not meet its March 31 vaccine delivery deadline.

Investigators found 10 main themes characterizing the differences between primary care clinics classified as high- and low-performing in distributing diabetes care.

Rates of hepatocellular carcinoma were highest among persons living with HIV who have higher RNA levels, lower CD4 cell counts, or used injection drugs.

Study findings presented at ENDO 2021, the Endocrine Society's annual meeting, show rates of hearing loss among 28 patients who took teprotumumab were higher than previously reported in phase 2 and 3 trials.

Sleep quality may be as significant as estrogen withdrawal in determining weight gain risk in women, according to a study presented virtually at the Endocrine Society’s 2021 Annual Meeting.

Among patients with atrial fibrillation (AFib) in the RATE-AF trial, the index-beat approach produced superior results on a potential diagnosis of heart failure vs consecutive-beat methods.

Randomized clinical trial results published in Cephalalgia show that trans-nasal high-flow dry gas therapy may play a role in reducing migraine-associated pain.

An independent committee expresses concern on US efficacy data for AstraZeneca's COVID-19 vaccine; cases of COVID-19 are on the rise in over half of states; wildfire smoke is associated with a significant spike in pediatric respiratory care visits.

New research shows eating before 8:30 am may reduce risk factors for type 2 diabetes as individuals who did so exhibited lower blood sugar levels and less insulin resistance.

A study of Korean patients with chronic obstructive pulmonary disease (COPD) found that a paradoxical response to short-acting bronchodilators may reduce lung function and quality of life.

Disc neovascularization (NVD) was less frequent among patients with proliferative diabetic retinopathy but was associated with more resistance to currently available treatments compared with neovascularization elsewhere (NVE), according to post hoc analysis findings published in JAMA Ophthalmology.

A recent study found that a sizable portion of the commercially insured asthma population lacks disease control, regardless of asthma severity, signaling a needed shift in treatment strategies.

Compared with healthy controls, patients with episodic migraine and patients with chronic migraine exhibited differing structural brain network characteristics, potentially indicating maladaptive reorganizations of headache-related brain circuits which could lead to migraine attacks or secondary alterations to pain.

A US trial finds AstraZeneca's COVID-19 vaccine to be 79% effective in preventing the virus; parents of children enrolled in virtual school are more likely to report negative physical, mental, and emotional health; Anthony Fauci, MD, says the UK COVID-19 variant is likely tied to 30% of US infections.

Despite patients with pulmonary arterial hypertension reporting good quality of life and low symptom severity, functional limitations persisted, suggesting improvements to the patient experience are needed, according to researchers.

A panel at the NCCN Virtual Annual Meeting finds that while primary care physicians and oncologists can share information, records may not be well integrated and in easy-to-use formats.

Dayna Clark, MPH, and Kalpana Ramiah, DrPH, MSc, explain why patient trust is important for hospitals to have, as discussed in their poster presented at the 2021 AcademyHealth National Health Policy Conference.

Amid the pandemic, organizations utilizing a value-based care reimbursement model may be better positioned than those using a fee-for-service model to delineate high-risk patients and manage their care, particularly for long-term symptoms that may arise due to COVID-19.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

Pediatric patients with poorly controlled type 1 diabetes have a 10 times greater risk of complications and death from COVID-19 compared with children whose diabetes is well controlled, according to new research.

Penn Medicine's Stephen Schuster, MD, offers an overview of an eventful year in CAR T-cell therapy at the NCCN Virtual Annual Meeting.