Non-Hodgkin Lymphoma (NHL)

Latest News
October 30th 2024

Higher TMB, PD-L1 Expression Correlate With Shorter Survival in Hematologic Malignancies

October 13th 2024

Miles Matter: The Geographic Disparity That Impacts Access to CAR T Therapy

October 8th 2024

Preclinical Model Suggests Efficacy of Combining Capivasertib With Venetoclax Against DLBCL

September 25th 2024

Combination of Magrolimab and Rituximab Well Tolerated in Patients With Refractory/Relapsed Indolent NHL

September 21st 2024

Lenalidomide-Obinutuzumab Combo Yields Promising Results in Relapsed NHL

Video Interviews
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July 13th 2024

Dr Anna Sureda on the Evolving Treatment Landscape for Relapsed/Refractory DLBCL, Follicular Lymphoma

February 8th 2024

Dr Ann LaCasce: T-Cell Engagers Have Improved DLBCL Outcomes, but Questions on Optimal Use Remain

June 9th 2023

Epcoritamab Approval Expands Treatment Armamentarium for DLBCL

Continuing Medical Education
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November 21st 2024

ASH Annual Meeting Coverage: Highlighting the Recent Updates in TKI Use in the Treatment of CML – Insights and Application for Managed Care

December 18, 2024 | 1:00 PM & 8:00 PM ET
November 21st 2024

Recent Advances in BCMA-Directed Treatment in Multiple Myeloma: Insights and Application for Managed Care

1.0 Credits / Hematologic Cancer, Oncology
November 21st 2024

Keeping Pace With New Developments in Multiple Myeloma: Updates and Strategies to Optimize Bispecific Antibodies and CAR T-Cell Therapy

1.5 Credits / Oncology, Hematology, Hematologic Cancer
November 21st 2024

Addressing the Gaps and Clinical Challenges in Chronic Lymphocytic Leukemia: Updates and Strategies for Managed Care

1.5 Credits / Hematology, Hematologic Cancer, Oncology

More News

Lymphoma diagnosis | Image Credit: © Vitalii Vodolazskyi - stock.adobe.com
September 13th 2024

Patients With B-Cell Cancers Have History of Increased Antimicrobial Use

Nameera Temkar, MD
Danish patients who were diagnosed with certain lymphomas and other B-cell malignancies demonstrated increased antimicrobial use for at least a decade before their diagnosis.
Recombinant Hirudin shows promise in the treament of DLBCL | image credit: David A Litman - stock.adobe.com
September 5th 2024

Recombinant Hirudin May Help Treat Diffuse Large B-Cell Lymphoma 

Karen Jacobson-Sive
Recombinant Hirudin (rH) inhibited the polarization of M2-type macrophages and protease-activated receptor-1 (PAR-1) in diffuse large B-cell lymphoma (DLBCL).
Dr Jason Romancik, Emory Winship Cancer Institute
August 30th 2024

Dr Jason Romancik on Novel Lymphoma Therapies, Increasing Costs of Care

Rose McNulty
Jason Romancik, MD, a board-certified hematologist at Emory Winship Cancer Institute, discusses the current treatment landscape in aggressive lymphoma and drivers of high care costs.
Cancerous cells | image credit: Dr_Microbe - stock.adobe.com
August 26th 2024

Multiplex Spatial Analysis Highlights Mechanisms of Refractory cHL

Jared Kaltwasser
Improvements in multiplex immunofluorescence and spatial analysis have enabled a better understanding of the ways classical Hodgkin lymphoma evades the immune system.
Full results from the inMIND trial of of lenalidomide and rituximab with or without tafasitamab in lymphoma are expected to be submitted for presentation at an upcoming medical meeting. | Image credit: airdone - stock.adobe.com
August 21st 2024

Phase 3 Trial of Tafasitamab in Follicular Lymphoma Meets Primary End Point

Jordyn Sava
The phase 3 inMIND trial evaluating tafasitamab in combination with lenalidomide and rituximab in relapsed or refractory follicular lymphoma showed promising progression-free survival findings, according to topline results.
Cytokine release concept | image credit: Bijac - stock.adobe.com
August 16th 2024

Cytokine Release Syndrome in CAR T-Cell Therapy: A Common Yet Controllable Complication in DLBCL

Kimberly Rath, PharmD
CAR T-cell therapy results in a high incidence of cytokine release syndrome, but it is manageable in most cases.
Anna Sureda, MD, PhD
August 10th 2024

Advancements in R/R Lymphoma: Bispecific Antibodies in Focus

Brooke McCormick Maggie L. Shaw
In part 1 of our interview with Anna Sureda, MD, PhD, president of the European Group for Blood and Marrow Transplantation, she summarized the current treatment landscape for relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) and follicular lymphoma (FL).
The current lack of comprehensive data reflects an urgent need for more robust data and reporting with regard to BsAbs in R/R non-Hodgkin lymphoma and multiple myeloma. | Image credit: Vitalii Vodolazskyi - stock.adobe.com
August 8th 2024

Scant Infection Data for Patients With R/R MM, NHL Treated With BsAbs

Jared Kaltwasser
Better reporting is needed to create better guidelines for tracking infection risk in patients with relapsed or refractory non-Hodgkin lymphoma or multiple myeloma, investigators concluded.
doc interviewing patient | Image Credit: ChasingMagic/peopleimages.com-stock.adobe.com
August 1st 2024

Accurately Capturing Experiences of Patients With NHL

Jared Kaltwasser
Investigators wanted to know how well the NFlymSI-18 assessment was able to assess patient-reported outcomes in people with indolent B-cell non-Hodgkin lymphoma (NHL).
Yasmin H. Karimi, MD
July 25th 2024

FDA Approval of Epcoritamab Offers New Hope for R/R Follicular Lymphoma Treatment

Hayden E. Klein
“It's nice to have another option that we can discuss with patients,” said Yasmin H. Karimi, MD, University of Michigan, about epcoritamab’s label expansion for difficult-to-treat relapsed/refractory (R/R) follicular lymphoma.
BeiGene Hopewell facility | Image credit: BeiGene
July 23rd 2024

BeiGene Opens $800M Flagship US Facility in New Jersey

Mary Caffrey
New Jersey Governor Phil Murphy joined BeiGene CEO John Oyler and about 300 guests to open the facility, located in Hopewell, New Jersey. A version of this article appeared in the August issue of Evidence-Based Oncology.
CAR T | Image Credit: Christoph Burgstedt-stock.adobe.com
July 23rd 2024

In LBCL, Barriers to CAR T Remain: SDOH and More

Gayle Turim Dickstein
The social determinants of health (SDOH) that need to be tackled most urgently when it comes to which patients with large B-cell lymphoma (LBCL) do and do not receive chimeric antigen receptor T-cell therapy (CAR T) are age, sex, income, and race/ethnicity.
Tycel Phillips, MD, City of Hope
July 16th 2024

The Importance of Treatment Sequencing in Mantle Cell Lymphoma

Mary Caffrey Maggie L. Shaw
We recently spoke with Tycel Phillips, MD, associate professor, Division of Lymphoma, Department of Hematology & Hematopoietic Cell Transplantation, City of Hope, about his team’s interim analysis of their dose-escalation study of glofitamab against relapsed/refractory B-cell non-Hodgkin lymphoma.
Lymphoma diagnosis | Image Credit: © Vitalii Vodolazskyi - stock.adobe.com
July 10th 2024

DA-EPOCH-Rituximab: Successfully Treating PMBCL in a Transgender Woman

Gayle Turim Dickstein
A case study describes the disparate factors that played into the chemotherapy and other treatment decisions made by a team in Japan when addressing their patient’s primary mediastinal large B-cell lymphoma (PMBCL).
CART and gene therapy | Image Credit: ArtemisDiana-stock.adobe.com
July 9th 2024

Late Effects of CAR T-Cell Therapy in Lymphoma

Kimberly Rath, PharmD
In this new analysis, investigators review the late adverse events associated with anti-CD19 chimeric antigen receptor (CAR) T-cell therapy for relapsed/refractory B-cell non-Hodgkin lymphoma.
non-Hodgkin lymphoma | Image Credit: MQ-Illustrations-stock.adobe.com
July 6th 2024

Study to Quantify Non-Hodgkin Lymphoma Risk in HIV

Karen Jacobson-Sive
This meta-analysis study will estimate the global and regional burden of HIV-associated non-Hodgkin lymphoma to aid the development of prevention and control strategies.
DLBCL | Image Credit: Image Credit: laszlo-stock.adobe.com
July 1st 2024

ViPOR: Novel Targeted Therapy Combination Shows Potential in Relapsed DLBCL

Gayle Turim Dickstein
The 5 agents in ViPOR—including venetoclax and lenalidomide—worked better together in a phase 1b/2 trial than they previously have, individually, in treating patients with certain diffuse large B-cell lymphoma (DLBCL) subtypes.
FDA approved | Image credit: ArtEternal – stock.adobe.com
June 27th 2024

Epcoritamab Gets Label Expansion for Difficult-to-Treat R/R Follicular Lymphoma

Hayden E. Klein
The FDA approved epcoritamab-bysp to treat adults with relapsed or refractory (R/R) follicular lymphoma after 2 or more lines of systemic therapy.
microscopic image of DLBCL | Image Credit: David A Litman-stock.adobe.com
June 17th 2024

Polatuzumab Vedotin: Review Spotlights Its Use, Promise in DLBCL

Gayle Turim Dickstein
With its recent approvals around the world to treat newly diagnosed and relapsed/refractory diffuse large B-cell lymphoma (DLBCL), the antibody-drug conjugate polatuzumab vedotin is changing regimens for current and future patients, with manageable adverse effects.
Medical technology | Image credit: ipopba - stock.adobe.com
June 14th 2024

Dr Catherine Diefenbach on the Evolving DLBCL Treatment Landscape

Rose McNulty
Catherine Diefenbach, MD, an American Society of Hematology expert and director of the Clinical Lymphoma Program at NYU Langone's Perlmutter Cancer Center, discussed the evolving state of diffuse large B-cell lymphoma (DLBCL) therapeutics and exciting areas of research.
Case Reports: Managing DLBCL Associated With Papillary Thyroid Carcinoma
June 12th 2024

Case Reports: Managing DLBCL Associated With Papillary Thyroid Carcinoma

Kimberly Rath, PharmD
Case reports and systematic review found the combination of surgery, chemotherapy, and radiotherapy can effectively manage diffuse large B-cell lymphoma (DLBCL) associated with papillary thyroid carcinoma.
Stethoscope chart graph data | Image Credit: © amazing studio - stock.adobe.com
June 7th 2024

Obinutuzumab and Radiation Combo Shows Promise for Refractory DLBCL

Kimberly Rath, PharmD
A small retrospective study found that combining obinutuzumab with radiation therapy may offer a viable and well-tolerated treatment option for patients with refractory diffuse large B-cell lymphoma (DLBCL).
dlbcl | Image Credit: laszlo-stock.adobe.com
June 3rd 2024

How the Tumor Microenvironment Affects DLBCL Prognosis, Treatment

Gayle Turim Dickstein
Further acknowledgement and study of the tumor microenvironment in diffuse large B-cell lymphoma (DLBCL) could eventually result in much more personalized—and effective—treatments.
Lymphoma word block image | Image Credit: © airdone - stock.adobe.com
May 27th 2024

Key Features of Rare Fibrin-Assisted Diffuse Large B-Cell Lymphoma

Kimberly Rath, PharmD
A case study details the cytological and histological features of fibrin-assisted diffuse large B-cell lymphoma in a patient with no clinical symptoms, highlighting the diagnostic challenges of this condition.
Nurse holding older woman's hands | Image Credit: © Cecilie Arcurs/peopleimages.com - stock.adobe.com
May 24th 2024

IVIG Shows Promise in Protecting Older Patients With Lymphoma From COVID-19

Kimberly Rath, PharmD
Prophylactic intravenous immunoglobulin reduces COVID-19 infection rates in older patients with DLBCL with hypogammaglobulinemia undergoing reduced-intensity R-CHOP therapy.
Photomicrograph of a diffuse large B-cell lymphoma | Image Credit: ©DavidALitman - stock.adobe.com
May 16th 2024

Patient/Physician Teamwork: Treating a Rare Oral Presentation of DLBCL

Gayle Turim Dickstein
A very unusual case of lip-based diffuse large B-cell lymphoma (DLBCL) was treated successfully thanks to prompt diagnosis and chemotherapy treatments.
Health costs | Image credit: utah51 - stock.adobe.com
May 8th 2024

Study: Care Costs for R/R DLBCL Increase With Each Line of Therapy

Jared Kaltwasser
New therapies are helping patients, but are also driving up overall costs of care.
Lymphoma graphic | Image Credit: © MP Studion - stock.adobe.com
May 2nd 2024

Much-Improved Outcomes for Follicular Lymphoma Transformed to DLBCL in the Rituximab Era, Study Finds

Gayle Turim Dickstein
Although histological transformation to diffuse large B-cell lymphoma (DLBCL) remains a common complication of follicular lymphoma, patient survival has increased significantly since the introduction of rituximab about 2 decades ago.
IV chemotherapy | Image Credit: Aidman - stock.adobe.com
April 24th 2024

Polatuzumab Vedotin and R-CHP Appropriate for Untreated DLBCL

Luke Halpern
Population pharmacokinetic and exposure-response analyses revealed a favorable benefit-risk profilane for the treatment combination of polatuzumab vedotin and rituximab, cyclophosphamide, doxorubicin, and prednisone (R-CHP).
Doctors discussing a case | Image Credit: DelmaineDonson - stock.adobe.com
April 18th 2024

Real-World Study Reveals Key Insights Into DLBCL Treatment Patterns, Outcomes

Kimberly Rath, PharmD
A recent study offers valuable insights into the characteristics, treatment patterns, and outcomes of diffuse large B-cell lymphoma (DLBCL) in patients across different lines of therapy, providing a look into the landscape of DLBCL management.
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