HIV

The AJMC® HIV compendium is a comprehensive resource for clinical news and expert insights for the condition, including disparities in care, prevention of infection among at-risk groups, and the importance of viral suppression.

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HPV Vaccination Cost-Effective at Preventing Cervical Cancer in Patients With HIV

November 21st 2024

Women living with HIV can reduce their risk of cervical cancer using a human papillomavirus (HPV) vaccine that is both cost-effective and effective in preventing the virus.

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New Data Provide Clearer Picture on Adherence to Lenacapavir

November 18th 2024

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BIC/FTC/TAF Effective at Virologic Suppression in HIV Presenting Late

November 15th 2024

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Liver Steatosis, Fibrosis Highly Prevalent in People Living With HIV

November 12th 2024

Madalitso Juwayeyi
Empowering Young Women in the Fight Against HIV

November 8th 2024

Clarifying USPSTF Recommendations for HIV Pre-Exposure Prophylaxis (PrEP)

This discussion focuses on how to address barriers and disparities as obstacles to using PrEP, with a focus on USPSTF PrEP guidelines and ACA Part 47 for payers and providers.

This multi-stakeholder roundtable panel discussion will focus on how to address barriers and disparities as obstacles to the use of PrEP, with a focus on increased understanding and education around US Preventive Services Task Force (USPSTF) PrEP guidelines and Affordable Care Act Part 47 for payers and providers.
Continuing Medical Education
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November 21st 2024

Navigating the HIV Treatment Frontier: Equipping Managed Care Professionals With Strategies for Innovation, Access, and Adherence

1.5 Credits / HIV/AIDS, Infectious Diseases

More News

Raltegravir-Based ART Regimens Appear Superior to Efavirenz for Use Among HIV-Positive Pregnant Patients
May 13th 2020

Raltegravir-Based ART Regimens Appear Superior to Efavirenz for Use Among HIV-Positive Pregnant Patients

Maggie L. Shaw
Among the principal reasons for recommending initiating antiretroviral treatment (ART) among pregnant patients who are HIV positive is to prevent transmission of the virus to their unborn children. This number was estimated at 1.3 million pregnant women, as of 2018.
Sepsis Shown to Be Prevalent Among Patients With High HIV Viral Load
May 8th 2020

Sepsis Shown to Be Prevalent Among Patients With High HIV Viral Load

Maggie L. Shaw
Close to 6 million individuals die every year as a direct result of sepsis infection, with a majority of these deaths occurring in low- and middle-income countries. The HIV-positive population in sub-Saharan Africa is disproportionately affected by this opportunistic infection.
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May 5th 2020

STD Testing Rates, Service Receipt Among HIV-Positive MSM Remain Low

Maggie L. Shaw
The CDC recommends regular testing for bacterial sexually transmitted diseases (STDs) among all sexually active gay, bisexual, and other men who have sex with men (MSM). Chief among these STDs are gonorrhea, chlamydia, syphilis, and hepatitis C.
Motivations, Attitudes Distinguish Consistent Versus Inconsistent ART Adherence
May 1st 2020

Motivations, Attitudes Distinguish Consistent Versus Inconsistent ART Adherence

Maggie L. Shaw
According to 2015 CDC data, current viral suppression rates from antiretroviral therapy (ART) leave room for improvement among both HIV-positive individuals who are aware of their disease status and those receiving care, at 40.0% and 81.5%, respectively.
A Comprehensive Approach Is Best to Promote PrEP Use Among At-Risk Adolescents, CDC Says
April 29th 2020

A Comprehensive Approach Is Best to Promote PrEP Use Among At-Risk Adolescents, CDC Says

Maggie L. Shaw
Preexposure prophylaxis (PrEP) was first approved by the FDA in 2012, but only for use among adults. An indication was added in 2018 for its use among adolescents.
Is Anti-CMV Treatment Necessary to Reduce CMV Viral Replication in Patients With HIV?
April 24th 2020

Is Anti-CMV Treatment Necessary to Reduce CMV Viral Replication in Patients With HIV?

Maggie L. Shaw
Following interim results presented at the 2017 Conference on Retroviruses and Opportunistic Infections, a team of investigators from Vall d’Hebron in Spain delivered their final results at this year’s virtual conference on cytomegalovirus (CMV) viral load response to antiretroviral therapy compared with anti-CMV treatment.
Does an STI Diagnosis Spur Subsequent HIV Testing Among Adolescents?
April 20th 2020

Does an STI Diagnosis Spur Subsequent HIV Testing Among Adolescents?

Maggie L. Shaw
Chlamydia, gonorrhea, syphilis, and trichomoniasis are 4 sexually transmitted infections (STI) that have seen sharp increases in occurrence over the past 10 years. Their combined overall rate rose 31% between 2013 and 2017 and correlate with a lower overall HIV testing rate among adolescents.
HIV, Hepatitis C Testing Rates Remain Dismal Among Injection Drug Users
April 17th 2020

HIV, Hepatitis C Testing Rates Remain Dismal Among Injection Drug Users

Maggie L. Shaw
Despite being at an increased risk for HIV and hepatitis C, persons who inject drugs (PWID) are tested at dismal rates for both: just 8.6% and 7.7%, respectively, according to data from 2010 to 2017. PWID who live in rural communities are more likely to face barriers to adequate testing and care for both diseases.
HIV Testing Rates, Frequency Leave Room for Improvement in Kenya
April 14th 2020

HIV Testing Rates, Frequency Leave Room for Improvement in Kenya

Maggie L. Shaw
As of 2017, 184,718 young adult women and men were living with HIV in Kenya, for an annual prevalence of 2.61% and 1.34%, respectively. Female sex workers are at higher risk of contracting HIV.
Close to 100% of Active Duty Service Members Initiate ART and Achieve Viral Suppression, CDC Reports
April 9th 2020

Close to 100% of Active Duty Service Members Initiate ART and Achieve Viral Suppression, CDC Reports

Maggie L. Shaw
Between 2012 and 2018, 93.8% of HIV-positive active military service members were on continuous antiretroviral therapy (ART). Of this group, 99.0% were virally suppressed by the end of their first year on ART.
HIV Disproportionately Affects Transgender Women, CDC Reports
April 7th 2020

HIV Disproportionately Affects Transgender Women, CDC Reports

Alison Rodriguez
There is a great need for additional outreach to the transgender community, especially by addressing concerns that include fear and loss of confidentiality, distrust of the medical community, abandonment, and abuse.
What Is the Risk of Cardiovascular Disease in Youth With HIV?
April 3rd 2020

What Is the Risk of Cardiovascular Disease in Youth With HIV?

Gianna Melillo
Detectable viral load (VL) is associated with a significantly increased risk of cardiovascular disease (CVD) among US youth living with HIV, according to an abstract presented at the Conference on Retroviruses and Opportunistic Infections.
Evolocumab Lowers LDL-C in HIV-Positive Persons
March 31st 2020

Evolocumab Lowers LDL-C in HIV-Positive Persons

Maggie L. Shaw
Evolocumab (Repatha), a human monoclonal antibody and proprotein convertase subtilisin/kexin type 9 inhibitor, produced positive results in persons living with HIV in the BEIJERINCK study by reducing their levels of low-density lipoprotein cholesterol (LDL-C). These individuals have a risk of cardiovascular disease that is almost twice that of HIV-negative individuals.
COVID-19 Questions HIV-Positive Individuals Want Answered
March 24th 2020

COVID-19 Questions HIV-Positive Individuals Want Answered

Maggie L. Shaw
The environment surrounding the coronavirus disease 2019 (COVID-19) pandemic seems to change by the minute. The full extent to which HIV-positive individuals can be affected if they contract COVID-19, because they are immunocompromised, is not known. Recently, the CDC issued guidance for this patient population.
Study Results Recommend Ongoing, but Updated, HIV-1/HIV-2 Differentiation Testing
March 20th 2020

Study Results Recommend Ongoing, but Updated, HIV-1/HIV-2 Differentiation Testing

Maggie L. Shaw
Between 2010 and 2017, there were 327,700 new HIV infections in the United States. Of these, HIV-2 infections accounted for less than 0.03% of the total. It is important to differentiate which HIV strain an individual is infected with because HIV-2 is intrinsically resistant to nonnucleoside reverse-transcriptase inhibitors, which are typically used to treat HIV-1 infections.
People With HIV at a Higher Risk of Cardiovascular Diseases, Study Finds
March 16th 2020

People With HIV at a Higher Risk of Cardiovascular Diseases, Study Finds

Alison Rodriguez
The association of HIV infection with cardiovascular disease was particularly strong for heart failure and stroke.
Questions Remain About Second Patient Who Demonstrates HIV Cure
March 10th 2020

Questions Remain About Second Patient Who Demonstrates HIV Cure

Maggie L. Shaw
A second individual may have been cured of HIV following an allogeneic stem-cell transplant for stage 4b refractory Hodgkin lymphoma with Δ32-mutated cells, which are resistant to the virus. These cells did not express the CCR5 chemokine receptor, 1 of 2 methods of entry for HIV into a host cell.
What We're Reading: Second Person Cured of HIV Speaks Out; BMS' MM Therapy Fails Study; FDA to Review Biosimilar Bevacizumab
March 9th 2020

What We're Reading: Second Person Cured of HIV Speaks Out; BMS' MM Therapy Fails Study; FDA to Review Biosimilar Bevacizumab

AJMC Staff
A year after being only the second person to be cured of HIV, the “London Patient” revealed his identity; BMS announced today that its combination therapy for multiple myeloma—elotuzumab, lenalidomide, and dexamethasone—failed its primary endpoint of progression-free survival in its phase 3 ELOQUENT-1 trial; Biocon and Mylan N.V. announced that the FDA accepted their biologics license application (BLA) for MYL-14020, a proposed biosimilar to bevacizumab (Avastin), for review.
Next-Generation Sequencing Used to Characterize HIV Epidemic in Washington, DC
March 2nd 2020

Next-Generation Sequencing Used to Characterize HIV Epidemic in Washington, DC

Gianna Melillo
In 2018, Washington, DC, saw 340 newly diagnosed cases of HIV, according to a study published in Scientific Reports. The city’s rate is 5 times higher than the national rate, and it falls under the World Health Organization’s definition of an epidemic. Researchers used next-generation sequencing to gain a broader view of the disease’s dynamics in the DC area.
COPD Is a More Likely Comorbid Condition in HIV-Positive Individuals
February 29th 2020

COPD Is a More Likely Comorbid Condition in HIV-Positive Individuals

Maggie L. Shaw
Chronic obstructive pulmonary disease (COPD) occurs at a higher rate in individuals who have HIV compared with those who do not, and it has a global incidence of more than 380 million people. The progressive lung disease is also diagnosed at a younger age in HIV-positive persons compared with their HIV-negative counterparts, and higher rates of smoking may be to blame.
What We're Reading: Florida Doctor Stole Millions; Rural Areas and HIV Risk; Disposable Vapes Replace Juul
February 18th 2020

What We're Reading: Florida Doctor Stole Millions; Rural Areas and HIV Risk; Disposable Vapes Replace Juul

AJMC Staff
A vascular surgeon in Florida allegedly stole $26 million from insurers and the government; a new report finds many rural areas are still at risk of an HIV outbreak; new disposable flavored vape pens have largely replaced Juul use among teens.
Youth Newly Diagnosed With HIV Have Advanced Infection, Higher Viral Loads
February 18th 2020

Youth Newly Diagnosed With HIV Have Advanced Infection, Higher Viral Loads

Maggie L. Shaw
Close to 80% of HIV-positive individuals are shown to be virally suppressed through their most recent test results, according to data from 2016 through 2018, as well as 32% to 63% of adults older than 24 years. Youth with a new HIV diagnosis, however, come in at only 12%.
What Can Be Done to Improve the HIV Testing Rate of At-Risk Teenage Boys?
February 11th 2020

What Can Be Done to Improve the HIV Testing Rate of At-Risk Teenage Boys?

Maggie L. Shaw
Among the general population of the United States, 14.5% of HIV-positive individuals do not know their disease status. This rate increases to 51.5% of 13- to 24-year-olds, among whom men who have sex with men account for 80% of new HIV infections.
Enrollment in AIDS Drug Assistance Programs Linked With Viral Suppression, Study Finds
February 10th 2020

Enrollment in AIDS Drug Assistance Programs Linked With Viral Suppression, Study Finds

Alison Rodriguez
Enrollment in AIDS Drug Assistance Programs (ADAPs)–funded Qualified Health Plans (QHPs) is associated with viral suppression (VS) across states and demographic groups. People living with HIV who engage in care and have QHPs have a higher VS rate than those who received medications from direct ADAPs.
What We're Reading: Gilead Dealt Patent Setback; Merck Spins Off Businesses; Governors' Medicaid Worries
February 6th 2020

What We're Reading: Gilead Dealt Patent Setback; Merck Spins Off Businesses; Governors' Medicaid Worries

AJMC Staff
The Patent Trial and Appeals Board delivered a setback to Gilead Sciences, rejecting its attempt to invalidate a pair of Truvada patents owned by the CDC; Merck is spinning off some businesses in order to focus on its oncology drug pembrolizumab, including its biosimilars operations; Republican and Democratic governors are worried that a proposed CMS fiscal accountability rule for Medicaid will reduce access to healthcare.
What We're Reading: FDA Launches HIV Drug Database; HIV Vaccine Trial Fails; NJ Enacts Coronavirus Task Force
February 4th 2020

What We're Reading: FDA Launches HIV Drug Database; HIV Vaccine Trial Fails; NJ Enacts Coronavirus Task Force

AJMC Staff
The FDA launched a mobile-friendly, interactive database providing information on eligible HIV antiretroviral treatments available; an HIV vaccine trial by Fred Hutchinson Cancer Research Center ended after failing to provide protection from the virus; New Jersey Governor Phil Murphy established a coronavirus task force to manage the state’s preparedness and response to the virus.
What Is the True Cost of the High Price of ART?
February 3rd 2020

What Is the True Cost of the High Price of ART?

Maggie L. Shaw
Antiretroviral treatment (ART) is the regimen mainstay for everyone who has HIV, irrespective of infection duration. More than twice as many options for ART were available in 2018 as were offered in 2012—but this did not equal cheaper prices. Between 2012 and 2018, the average wholesale price for initial ART jumped 34% for most people with HIV.
Study Finds Discrepancies From Guidelines in Prescribing Practices for Pregnant Women Living With HIV
February 2nd 2020

Study Finds Discrepancies From Guidelines in Prescribing Practices for Pregnant Women Living With HIV

Alison Rodriguez
The authors noted that pregnant women are typically excluded from clinical trials investigating the safety and tolerability of HIV medications.
Innovative Research Program Provides Deeper Understanding of HIV's Dynamic Process
January 28th 2020

Innovative Research Program Provides Deeper Understanding of HIV's Dynamic Process

Maggie L. Shaw
Participants in Last Gift, an end-of-life HIV research program from UC San Diego, donate their blood and their bodies so researchers can uncover all the places that HIV hides, to both fight the disease and stop it. Before each autopsy, the following is read: “From our first breath to our last, each of us tells a unique story. Here, we honor our Last Gift participants for their altruism to further research into HIV and the human condition. We take this moment of silence to honor their gifts and express our gratitude for all the discoveries their selfless donations will yield.”
NY Attorney General, Federal Trade Commission Sue Martin Shkreli
January 28th 2020

NY Attorney General, Federal Trade Commission Sue Martin Shkreli

Gianna Melillo
New York Attorney General Letitia James announced a lawsuit filed against 2 former chief executive officers of Turing Pharmaceuticals, now known as Vyera Pharmaceuticals: “Pharma Bro” Martin Shkreli, currently serving a 7-year sentence in federal prison for securities fraud, a crime that took place before the launch of Vyera, and his business partner Kevin Mulleady.
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