Jared is a freelance writer for The American Journal of Managed Care® (AJMC®), and previously worked as a senior editor for HCPLive® at MJH Life Sciences®.
He has an MA from University of Sioux Falls. You can connect with Jared on LinkedIn.
Biomarkers May Predict Treatment Response in Steroid-Refractory/Dependent GVHD
Lower levels of certain biomarkers were predictive of treatment response for graft-versus-host disease (GVHD) at day 28, investigators found.
AChR Antibody Titers May Help Predict Conversion to Generalized Myasthenia Gravis
The new report suggests patients with acetylcholine receptor (AChR) antibody titers above 8.11 nmol/L were at higher risk of conversion.
Accurate Remote Assessment of Psoriasis Possible From Patient Photographs, Questionnaire Responses, Study Finds
In this new analysis, investigators found significant agreement between in-person and remote assessments.
Treatment of Rare Anemias Shifting Rapidly
Investigators said several new anemia therapies are in development, and many of them may help wide swaths of patients.
Ruxolitinib Reduces Posttransplant GVHD Risk in Pediatric β-Thalassemia Major
Patients who had ruxolitinib added to their prophylactic regimens had lower rates of acute and chronic graft-versus-host disease (GVHD).
Study: MuSK-Specific Antibodies Do Not Explain Variation in Serum IgG4 Levels in People With MuSK MG
People with muscle-specific kinase myasthenia gravis appear to have more active antibody responses in general, the study found.
JAK2 Mutations Rare, With Unclear Implications in MDS
A new report found only about 2.8% of people with myelodysplastic syndromes (MDS) have JAK2 mutations.
New WHO Biosimilar Guidelines Aim to Streamline, Clarify Regulations
The new recommendations from the World Health Organization (WHO) urge viewing the totality of evidence when evaluating biosimilar products.
Predicting Post-AlloSCT Outcomes in Myelofibrosis
The EASIX scoring system should not be used to predict outcomes following allogeneic stem cell transplantation (alloSCT) in patients with myelofibrosis.
Opioid Prescription Decision Tool May Be Feasible Option to Curb Overprescribing
A feasibility study shows many providers intended to continue using the tool, although some said they did not have sufficient time or did not need the tool.
Polygenic Risk Scores Predict Cancer Cases, but Not Aggressiveness in Prostate Cancer
The new report found polygenic risk scores likely will not help identify patients at highest risk.
Data on Veterans Suggest Ruxolitinib Led to Significant PMF Survival Gains
The risk of death among people with primary myelofibrosis (PMF) dropped by 53% after ruxolitinib’s introduction, the study found, although the data also suggested only 8.5% of patients were prescribed the drug.
Case Report and Review Examines MG and COVID-19
Just 26 cases have been reported in which myasthenia gravis (MG) symptoms appeared following vaccination.
RNS Not a Meaningful Prognostic Tool in Myasthenia Gravis
While repetitive nerve stimulation (RNS) remains a mainstay of myasthenia gravis diagnosis, investigators said it does not appear to yield prognostic insights.
Masked PV Case Highlights Challenge of Diagnosis in Younger Women
Features of polycythemia vera (PV) can easily be misattributed to other causes, such as iron depletion or arterial hypertension.
Elevated C-Reactive Protein Tied to Lower Survival Rates in Prostate Cancer
Overall survival, cancer-specific survival and progression-free survival were all negatively affected by elevated C-reactive protein levels, this study found.
Inflammation Could Prove Meaningful Target in Myasthenia Gravis
The article suggests the inflammatory components of myasthenia gravis have been underexplored in the effort to develop new therapies.
Study Identifies FGFR3 as Biomarker for Superior Outcomes in NSCLC
Positive expression levels of the biomarker were more common in adenocarcinoma than in squamous cell carcinoma, among patients who had non–small cell lung cancer (NSCLC).
Similar Survival Rates Seen Among Black African Americans With PMF, Other Groups
The study also found, however, that transplant outcomes appear to be worse for Black African American patients who have primary myelofibrosis (PMF), although the study utilized a small sample size.
Spleen Response Closely Linked With Survival in MF While on Ruxolitinib
Patients with myelofibrosis (MF) who achieved a spleen response while taking ruxolitinib and lost it had survival outcomes similar to patients who did not respond, according to results from a real-world study.
Live Cell-Based Assays May Find Antibodies in Some Seronegative MG Cases
A different type of test may improve diagnosis for some patients with myasthenia gravis (MG).
Immune Signature Could Help Tailor Treatment Choices in NSCLC
The authors identified 2 subgroups with non–small cell lung cancer (NSCLC) who had different responses to common cancer therapies.
Ruxolitinib Well Tolerated in Untreated Patients With Polycythemia Vera
The results of the futility analysis also suggest the therapy leads to significant clinical benefits.
Real-World Data Show SCLC Outcomes Remain Grim
The authors say newer treatment options for small cell lung cancer (SCLC) may lead to improvement in this area of high unmet need.
Two Cases Demonstrate Potential Renal Complications of MDS/MPN
Evidence suggests as many as 29% of people with myeloproliferative neoplasms (MPN) or myelodysplastic syndrome (MDS)/MPN have chronic kidney disease.
Links Between Ancestry, Immunogenomic Landscape Investigated in Prostate Cancer
The study found 143 loci where somatic copy numbers were varied based on genetic ancestry.
Surgical Quality Metric Adherence Substantially Improves Outcomes in Early NSCLC
Overall survival and recurrence-free survival showed substantial improvement when physicians more closely followed quality recommendations for non–small cell lung cancer (NSCLC).
Case Shows Difficulty of Diagnosing Myasthenia Gravis Following COVID-19
The patient, an 83-year-old man, experienced onset of myasthenia gravis after a severe SARS-CoV-2 infection.
Many Rural Hospitals Lacked Oncology Care, Telehealth, or Both Before the Pandemic
The report helps clarify the urban/rural divide in cancer outcomes and the digital divide in telehealth access.
New Prostate Cancer Screening Method Could Reduce Risk of Overdiagnosis
The method had high rates of sensitivity and specificity, although its sensitivity was somewhat lower in cases of localized prostate cancer.