Article

What We're Reading: Off-Label Drug Use and Adverse Drug Events

Author(s):

What we're reading, November 3, 2015: off-label drug use is associated with a higher risk of adverse drug events; CMS finalizes its rule for advanced care planning for end-of-life care; and Californians send measure to cut drug prices to the vote.

Off-Label Drug Use Associated With Higher Adverse Drug Event Risk

A study published in JAMA Internal Medicine suggested caution when prescribing drugs for off-label use when there is a lack of strong evidence as the practice is associated with adverse drug events. While the overall rate of adverse drug events for off-label use was higher than that for on-label use, off-label use with strong scientific evidence had the same risk as on-label use. Risk for adverse events were higher for drugs approved between 1981 and 1995, and for those used by women, patients receiving 5 to 7 drugs, and patients receiving cardiovascular drugs.

Read more.

CMS Finalizes Rule to Plan for End-of-Life Care

After receiving comments supporting the proposed rule to enable physicians to discuss advance care planning with Medicare beneficiaries, CMS is finalizing the rule. Advanced care discussions about how a patient would like to be care for when they are dying can occur early, before an illness progresses, or during the course of treatment. CMS is also finalizing payment for advance care planning when it is part of the Annual Wellness Visit.

Read more.

California Measure Curbing Drug Costs Will Go to Vote

In California, advocates of a proposed measure that would slash drug prices receive more than enough signatures to place the measure on the ballot in November 2016. The proposed measure would require that programs where the state pays for a drug, even if the state did not purchase the drug directly, would pay no more than the price negotiated by the US Department of Veterans Affairs, reported San Jose Mercury News.

Read more.

Related Videos
Jaime Almandoz, MD, MBA
Sam Peasah, PhD, MBA, RPh, director for the Center of High-Value Health Care at the University of Pittsburgh Medical Center (UPMC)
Image credit: Medical technology and futuristic concept. Doctor hologram modern virtual screen interface | SOMKID - stock.adobe.com
JC Scott, CEO and president of The Pharmaceutical Care Management Association (PCMA)
Galen Shearn-Nance, BS, and Johnie Rose, MD, PhD
Galen Shearn-Nance, BS
Neha Kashalikar, PharmD, director of strategic pharmacy consulting, MassHealth
Dr Johnie Rose
Adam Colburn, JD, associate vice president for congressional affairs, AMCP
Leigh Maria Ramos-Platt, MD
Related Content
AJMC Managed Markets Network Logo
CH LogoCenter for Biosimilars Logo