The Clinical and Economic Implications of Alzheimer Disease Across Patients, Families, and the Health Care System

Author(s):

Derek van Amerongen, MD, MS,Soeren Mattke, MD, DSc

A panel of experts on Alzheimer disease provide insights on symptoms the patient might experience and the impact of the disease on patients, families, caregivers, and the health care system.

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EP: 1.The Clinical and Economic Implications of Alzheimer Disease Across Patients, Families, and the Health Care System

EP: 2.Recent Insights into the Pathophysiology of Alzheimer Disease

EP: 3.Genetic Aspects of Alzheimer Disease

EP: 4.The Patient Experience: From Symptoms to Diagnosis of Alzheimer Disease

EP: 5.Potential Consequences of Early Diagnosis of Alzheimer Disease

EP: 6.Criteria for Diagnosing Alzheimer Disease and the Role of Testing

EP: 7.Exploring the Economic Impact of Advanced Approaches for Diagnosing Alzheimer Disease

EP: 8.Clinical Impact of the Introduction of Disease-Modifying Treatments for Alzheimer Disease

EP: 9.Clinical Decision-Making for Alzheimer Disease Management

EP: 10.Cost, Value, and Affordability of Treatment for Alzheimer Disease

EP: 11.Advancements in Alzheimer Disease Treatment: Emerging Drug Candidates

EP: 12.Exploring the Influence of Administration Routes on Medical Costs and Caregiver Burden

EP: 13.Payer Coverage Considerations for New Treatments for Alzheimer Disease

EP: 14.Concluding Remarks: Impact of Alzheimer Disease, Promising Treatments in Development, and Future Outlook

Please describe the clinical impact of AD in terms of symptoms the patient might experience before diagnosis and the progression of symptoms over time, and how this impacts not only the patient, but families/caregivers and the healthcare system.
What is the impact of AD in terms of costs related to diagnosis and treatment, and how this impacts society at large?
Discuss the genetic factors associated with AD. How do mutations in genes such as APP, PSEN1, and PSEN2 contribute to the pathophysiology of the disease? How do different alleles of APOE4affect risk of developing AD?