Key Challenges and Unmet Needs in Newly Diagnosed Driver-Negative mNSCLC

EP: 1.Biomarker Testing and Guideline-Recommended Care in mNSCLC

EP: 2.Strategies to Increase Biomarker Testing Rates

EP: 3.Limitations on Optimal Biomarker Testing Rates

EP: 4.Impact of Biomarker Testing on Treatment Selection and Outcomes

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EP: 5.Key Challenges and Unmet Needs in Newly Diagnosed Driver-Negative mNSCLC

EP: 6.NCCN Recommendations by PD-L1 Expression Level

EP: 7.Limitations of NCCN PD-L1 Expression Recommendations

EP: 8.Emerging Data and Evidence for Dual Immunotherapy plus Chemotherapy in First-Line mNSCLC

EP: 9.Genetic Alterations Impacting Treatment Response and Biomarker Testing Rates in mNSCLC

EP: 10.Molecular Characteristics Beyond Mutations Influencing Immunotherapy Response

EP: 11.Clinical Factors Impacting Immunotherapy Response and Optimizing Patient Selection

EP: 12.Overcoming Immunotherapy Resistance: Identifying Non-Responders and Novel Approaches

EP: 13.Key Takeaways on Enhancing Outcomes for mNSCLC Without Targetable Driver Mutations

Video content above is prompted by the following:

• Describe the key challenges and unmet needs for patients with newly diagnosed mNSCLC lacking targetable driver mutations.
• What proportion of mNSCLC patients harbor drivers like EGFR, ALK, etc?
  • How does the presence of these mutations impact prognosis and guide first-line treatment?
• What are the unique challenges and unmet needs for specific subgroups of mNSCLC patients without drivers, such as those with without PD-L1 expression, squamous histology, or brain metastases?
• Beyond PD-L1, what factors do you consider when selecting first-line treatment in the driver-negative setting?