Opinion

Video

EHA 2024: Teclistimab in High-Risk Relapsed/Refractory Multiple Myeloma

Author(s):

Joseph Mikhael, MD

Dr. Mikhael discusses the safety and usefulness of tesclistimab in patients with high-risk refractory multiple myeloma.

Video content above is prompted by the following question:

  1. Discuss the data presented at EHA 2024 on the efficacy and safety of teclistimab in patients with relapsed/refractory multiple myeloma (RRMM) with high-risk features: a subgroup analysis of the phase 1/2 MajesTEC-1 study. (Abstract)
    1. What was the objective of the subgroup analysis of this study?
    2. How was this study designed/what methodology was used?
    3. What results were presented?
      1. N=165
    4. N=24 aged ≥75 years
    5. N=20 ISS stage III
    6. N=38 high-risk cytogenetics
    7. N=28 extramedullary disease
    8. N=18 bone marrow plasma cells
    9. N=50 penta-drug refractory
      1. Median follow up ~30 months across subgroups
      2. Objective Response Rate (ORR)
      3. Median duration of response (mDOR)
      4. Safety
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