Clinical

A new study may help clear up questions about the superiority of venetoclax with hypomethylating agents in patients who are deemed to be at high risk of treatment-related mortality.

Friction of surgical instruments has the greatest association with incisional Descemet membrane detachment (DMD) during cataract surgery, according to results of a case series published in JAMA Ophthalmology.

The analysis, published in Cephalalgia, found that more than 50% of patients exhibited reversion from chronic migraine to episodic migraine after week 12 of the double-blind treatment phase.

Clarence Moore, PharmD, BCPS, BCOP, assistant professor at Shenandoah University in Ashburn, Virginia, discusses how stem cell therapy and heart health can help patients manage beta thalassemia.

Scientists in Japan describe how a population of spinal cord astrocytes appear to have a role in producing pain hypersensitivity.

A recent study found that patients with both chronic obstructive pulmonary disease (COPD) and diabetes using oral hypoglycemic agents had lower risks of severe exacerbations than controls.

Circulating tumor DNA (ctDNA) has a host of benefits in treating and managing patients with early-stage disease, noted Alexey Aleshin, MD, senior medical director of Oncology at biotech giant Natera.

A review published earlier this year examines the rationale and evidence for using a multidrug approach in pulmonary arterial hypertension (PAH).

A variety of factors contributed to discontinuation rates in FIDELIO-DKD, said George Bakris, MD, professor of medicine and director of the American Heart Association Comprehensive Hypertension Center at the University of Chicago Medicine.

Researchers identified new genetic associations that can predict individuals’ susceptibility to Takayasu arteritis, a rare type of vasculitis.

The research raises the possibility that the type of therapy used can increase the risk of tumor lysis syndrome from low to moderate in men with multiple myeloma (MM).

A new study helps explain immunological factors that appear to have an impact on the success rate of mogamulizumab in patients with adult T-cell leukemia-lymphoma (ATL).

Researchers found the application of FOLFOXai, an artificial intelligence (AI)–based predictor of response to FOLFOX chemotherapy in metastatic colorectal cancer (mCRC), may lead to improved treatment outcomes for some patients with mCRC and other cancers.

Among women hospitalized with coronavirus disease 2019 (COVID-19), use of metformin—a type 2 diabetes (T2D) drug used to manage blood sugar levels—was associated with a 21.5% lower risk of death.

Inqovi is an orally administered, fixed-dose combination of the DNA hypomethylating agent, decitabine, and cedazuridine, an inhibitor of cytidine deaminase.

SEQUOIA arm D study results show better outcomes are possible for patients with 17p-deletion CLL, explained Ian Flinn, MD, PhD, director of lymphoma research at Sarah Cannon Research Institute.

An increase in primary rhegmatogenous retinal detachment incidence (RRD) may be associated with a simultaneous increase in myopia among citizens residing in the Netherlands, according to study results published in JAMA Ophthalmology.

The presence of migraine is a significant risk factor for the development of subsequent peripheral artery occlusive disease, according to results of a retrospective cohort study published in the International Journal of Environmental Research and Public Health.

During a session at the at the 18th annual World Congress Insulin Resistance, Diabetes & Cardiovascular Disease presented by the Metabolic Institute of America, experts outlined the benefits and limitations of pharmacological, surgical, and lifestyle interventions for pediatric patients with obesity.

The new data provide hope that the therapy will prove effective for a patient group with limited options.

Researchers from the University of California San Francisco published their results in the Journal of Urology.

One patient had a complete response and the majority of patients achieved disease control at 12 weeks.

In the real world, the persistence rate with secukinumab to treat psoriatic arthritis was higher than with ustekinumab.

Previous studies have suggested that migraine is linked with higher visual neuronal excitability, which can be inhibited through noninvasive brain stimulation.

The lead investigator touted the benefits of subcutaneous administration of daratumumab in relapsed multiple myeloma (MM) during a presentation on practice-changing results ahead of the American Society of Hematology annual meeting.

Updated guidance in 6 key areas of asthma care focus on improving diagnosis, management, and treatment.

As higher estimated glomerular filtration rate (eGFR) equations indicate better kidney function, there has been increasing recognition that this may lead to inequitable and delayed care in treating chronic kidney disease (CKD) in Black adults.

Results of a retrospective case series revealed an association between blood-brain barrier disruption (BBBD)–related maculopathy and the number of BBBD treatment sessions patients underwent, suggesting a dose-dependent effect of the treatment.

Use of selexipag in patients with connective tissue disease–associated pulmonary arterial hypertension (CTD-PAH) resulted in outcomes similar to those seen in patients with idiopathic PAH, despite the traditionally poorer prognosis of CTD-PAH.

Researchers assessed 3 risk factors for migraine in children and adolescents: stress, sleep poverty, and alimentation.