Clinical

There are currently 3 FDA-approved therapies to treat cholangiocarcinoma with FGFR2 fusion or rearrangement, but these therapies face the development of resistance. Studies are underway to identify ways to overcome this resistance.

Liz Lightstone, MBBS, PhD, FRCP, professor of renal medicine for the Faculty of Medicine, Imperial College London, discussed how the potential teratogenic effects of novel therapies being investigated for lupus nephritis can impede clinical trial recruitment for women of childbearing age.

Compared with patients who have influenza infection, people infected with SARS-CoV-2 have a higher risk of epilepsy and seizures, according to a new study.

A survival benefit was elicited with the use of pemigatinib when used for patients with previously treated advanced cholangiocarcinoma who had an FGFR2 fusion or rearrangement.

Different dietary approaches were able to improve the state of health in patients with type 2 diabetes (T2D), with very-low-calorie ketogenic diets demonstrating better results on gut microbiota profile.

A new study has found that a drop in serum inorganic phosphate (iP) was an early predictor of severe cytokine release syndrome (CRS), suggesting that monitoring serum iP levels could help promote safer management of the most common toxicity associated with chimeric antigen receptor (CAR) T-cell therapy.

Jorge Larranaga, MD, provides his opinion regarding the criticality of urgency in LN treatment.

Jorge Larranaga, MD, and Alvin Wells, MD, PhD, describe the progression of SLE to lupus nephritis.

This new study explored how expression of SERPINB10 may be related to postoperative recurrence of and inflammation related to chronic rhinosinusitis with nasal polyps (CRSwNP).

A bill introduced by Senator Mike Lee, R-Utah, would prohibit the FDA requiring switching studies for biosimilars to gain interchangeability status.

A systemic review analysis evaluated associations between epilepsy and seizures in people with multiple sclerosis (MS).

Using data from patients with spinal muscular atrophy (SMA) type 1 and 2, researchers observed that chitotriosidase 1 levels in cerebral spinal fluid (CSF) changed over time after treatment with nusinersen, suggesting that the change could be indicative of treatment response.

The study findings suggest that eosinophilic esophagitis (EoE), like other atopic diseases, may be associated with infections.

Updated Kidney Disease: Improving Global Outcomes guidelines and a consensus report with the American Diabetes Association support the use of finerenone in certain patients who have chronic kidney disease (CKD) that may be linked to type 2 diabetes (T2D).

Immune checkpoint inhibitors can play a key role in the treatment of upper-GI and esophageal cancer.

Key opinion leaders navigate unmet needs across the treatment landscape of gastroesophageal cancer.

Managed care experts discuss health disparities among various patient populations affected by MDD.

Drs Cannon and Rothrock provide insights into their process for defining value among newly launched MDD treatments.

Investigators still do not fully understand how cannabidiol (CBD) works in patients with seizures, according to a new review.

In an interview at this year’s American Heart Association Scientific Sessions meeting in Chicago, Tochi M. Okwuosa, DO, cardiologist and director of cardio-oncology at Rush University Medical Center, discussed the importance of addressing cardiovascular disease (CVD) prevention in patients with cancer who are undergoing treatment.

A prospective study found that patients and providers saw benefits while using a virtual assistant integrated into a teledermatology program.

The investigators of this new study wanted to more clearly define the patient characteristics of the 2 main types of chronic rhinosinusitis: with nasal polyps (CRSwNP) and without nasal polyps (CRSsNP).

The study probed the role of body weight on gut permeability and systemic inflammation and the impact on asthma control and asthma status.

High levels of interleukin (IL)-26 levels correlate with an exaggerated inflammatory response that signifies severe cases of the disease, according to researchers.

The authors of the retrospective, observational study said it was the first to use electronic medical records to make direct comparisons of these 4 biologics for asthma.

A research letter published in Blood Advances details the first clinical evidence of sustained hematologic remission for cold agglutinin disease (CAD) after sutimlimab treatment discontinuation.

The biologic is the first drug that aims to delay the diagnosis of type 1 diabetes.

As providers strive to deliver seamless, collaborative, and deeply engaging care, advances focused on treating the whole health of a person, wherever they are in their care journey, will be necessary as the health care system continues to evolve to meet the needs of patients and providers alike.

New data show patients treated with chimeric antigen receptor (CAR) T-cell therapy as salvage therapy tended to have meaningful results despite treatment failure following B-cell maturation antigen (BCMA) CAR T.

Experts from US Oncology, Tennessee Oncology, AON, and COA dig into the details of implementing the Enhancing Oncology Model, set to take effect July 1, 2023.