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A recent study sought to learn more about how estrogen receptor signaling occurs in vivo in normal and cancerous tissue.

A new study found that in 50% of patients, the standard 12-week treatment regimen for hepatitis C could be shortened to as few as 6 weeks without compromising efficacy.

Researchers tested the hypothesis that a genetic risk score based on single-nucleotide polymorphisms may influence headache response to triptans in patients and found a significant relationship between triptan efficacy and the cumulative score of genetic risk.

As Arkansas said this week it removed thousands of people from its Medicaid expansion program for not reporting work requirements, advocates for those with low incomes said those subject to the rules are probably unaware of them.

The FDA announced Friday it expanded the approved use of brentuximab vedotin (Adcetris) in combination with chemotherapy for adult patients with certain types of peripheral T-cell lymphoma, using a new review process designed to increase efficiency.

Treatment of acute myeloid leukemia (AML) has remained a challenge, partly because of an insufficient understanding of the molecular mechanisms that promote and maintain the leukemic state of AML cells.

The addition of nivolumab to azacitidine led to significantly better overall response rate and overall survival compared with previous hypomethylating agent-based regimens in patients with relapsed acute myeloid leukemia (AML), according to the results of a recent phase 2 study.

Following release from prison or jail, people living with HIV have higher mortality rates than the general population, indicating that resources are needed to identify and treat HIV and other medical needs following release from incarceration in order to reduce mortality.

HHS Secretary Alex Azar plans to ensure his agency handles both the health and the human services, as stated in its name, of Americans. In a recent speech, he hinted that the Center for Medicare and Medicaid Innovation will be doing more work in areas adjacent to healthcare, such as food insecurity, and housing, utility, and transportation needs.

President Donald Trump is planning to announce details of his plan to expand the role of the private sector to deliver healthcare to veterans; research looking at connections between mental health and gun violence is not so clear cut; the suicide rate among Americans of working age (between 16 and 64) increased 34% from 2000 to 2016 across 17 states.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

An investigation into the effects of a self-management intervention (SMI) called “Better Living with COPD” found that the intervention had a significant positive short-term effect for patients with chronic obstructive pulmonary disease.

The November 2018 issue of The American Journal of Managed Care® (AJMC®) has a special focus on substance use disorder, but its studies also touch on disparities in patient portal adoption and the cost impacts of dementia. Here are 5 findings from the research published in the issue.

This week, the top managed care news included research that showed c​​​​ancer surpassed cardiovascular disease to be the leading cause of death in high-income counties; HHS Secretary Alex Azar announced a new mandatory payment model is coming to oncology; a policy change could make mental health treatment more available.

The FDA today announced new actions aimed at reversing the increasing trend of youth nicotine use and combating youth access to e-cigarettes. Though the agency stopped short of an expected ban on flavored e-cigarettes, it will move to outlaw menthol cigarettes and flavored cigars, 2 products that disproportionately harm African Americans.

An Oklahoma verdict against Aetna highlights insurer reluctance to pay for proton beam therapy.

A report assessing healthcare utilization and cost patterns in 6 regions across the United States highlighted stark differences in average healthcare costs, with Maryland falling 20% below the average and Colorado landing 19% above average.

US health officials said Thursday the number of high school students who reported being current e-cigarette users skyrocketed 78% between 2017 and 2018 to 3.05 million, as the FDA moved to create tougher regulations on e-cigarettes, although the agency did not propose the type of ban that some public health advocates hoped for.

Workers younger than 65 with employer-sponsored health insurance dramatically shifted to nurse practitioners and physician assistants between 2012 and 2016 as visits to primary care physicians decreased, according to a new report from the Health Care Cost Institute (HCCI).

When used in combination with rituximab, Hu5F9-G4 (5F9), a humanized monoclonal anti-CD47 antibody, promotes durable objective and complete response rates in lymphoma while also having minimal adverse events (AE), according to a phase 1b study published in New England Journal of Medicine.

The guidelines unveiled at the American Heart Association annual meeting discuss when patients at the highest risk could be treated with a PCSK9 inhibitor.

Michigan receives approval to implement outcomes-based drug contracts in Medicaid; in the first 10 days since open enrollment began, 1.2 million people have signed up for Affordable Care Act health plans, which falls short of the 1.5 million people who signed up in the first 9 days last year; new research has found that in states with lax gunshot laws, children are twice as likely to die from gunshot wounds compared with states with stricter laws.

America's Health Insurance Plans (AHIP) released what it said are 12 proposals to help increase affordability for people who buy insurance on the individual market who do not qualify for subsidies. Meanwhile, CMS said 1.2 million people signed up for health insurance during the first 10 days of open enrollment for the individual marketplaces.

One-third of neutropenic patients developed invasive infection following intensive chemotherapy, which was significantly associated with an increase in mortality up to 100 days after the start of neutropenia.

A large pooled analysis of 758,592 premenopausal women, conducted by the Premenopausal Breast Cancer Collaborative Group, identified an inverse association between body mass index (BMI) and the risk of breast cancer.

As physicians have an essential role in the fight against HIV—leading patients through the care continuum—understanding HIV-related stigma among physicians can inform development of interventions to reduce this stigma and promote positive clinical outcomes.

CMS' announcement of a new mandatory oncology bundled payment model wasn't a surprise. It reinforces CMS' continued commitment to creating innovative ways of transforming care.

A new study by Children’s National Health System researchers suggests that the majority of patients with cystic fibrosis (CF) may not achieve blood concentrations of antibiotics sufficiently high enough to effectively fight bacteria causing pulmonary exacerbations.

A widely used probiotic, Lactobacillus rhamnosus GG (LGG), stimulated bone formation in mice, according to a recent study.

HHS Secretary Alex Azar declares a public health emergency in California over ongoing wildfires; a new formulary from Express Scripts will encourage drug makers to move away from paying rebates and instead keep list prices low; part of Oscar Health’s expansion efforts has brought the insurer to Florida, but the company has said its efforts are being “stymied” by Florida Blue.