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Providing healthcare to millions of people requires a hugely complex system of hospitals, clinics, ambulances, research centers, suppliers, and governments-and that system needs re-engineering.

Despite a drop in the uninsured rate stemming from the Affordable Care Act, more Americans are putting off medical treatment because of the cost of healthcare, according to the results of an annual Gallup survey.

A study by the University of Colorado Cancer Center published in the journal PLoS ONE and concurrent phase I clinical trial is examining a new strategy: targeting both important cancer-causing pathways simultaneously.

The healthcare industry has made progress in reducing medical errors over the past 15 years, but it's not enough, according to Molly Joel Coye, MD, chief innovation officer of UCLA Health at the University of California, Los Angeles.

Early this week, Novation, a healthcare services company that oversees supply chain management, called on Genentech to reverse its decision to use only specialty drug distributors instead of wholesale distributors for its widely used anticancer treatments, Avastin, Rituxan, and Herceptin.

A new RAND study explores the range of possible causes that might explain observed international variations in the usage of medicines for selected disease areas: dementia, osteoporosis, cancer, diabetes, and hepatitis C.

More than 1 million Americans applied for coverage through the federal Marketplace during the first week of open enrollment, HHS reported in the first of its weekly data snapshots.

Attempts to contain emerging global health threats, like the current Ebola outbreak in West Africa, are hampered by barriers to sharing public health data, according to an international team of researchers.

The rule applies to restaurants, retail food establishments, and vending machines with 20 or more locations.

Authors in the New England Journal of Medicine discuss the prospects and pitfalls of implementing a new CMS fee for physicians who coordinate care for Medicare patients with multiple chronic conditions.

The trial, conducted across various tumor types, monitored PD-L1 expression in biopsy samples before and during treatment with the PD-L1 inhibitor MPDL3280A being developed by Genentech.

Eric C. Schneider, MD, senior principal researcher and distinguished chair in health care quality at RAND, and director of its Boston office, will join The Commonwealth Fund as senior vice president for policy and research on February 2, 2015.

Medical technology hazards remain a top safety issue for hospitals and can come in many forms. However, for the fourth year in a row, alarm hazards topped the annual Top 10 Health Technology Hazards list from the ECRI Institute.

Following on the heels of the FDA's advice on the risk of using morcellators for treating fibroids, researchers in France have released results of a study that delineates a method that can avoid the risk of morcellating a pre-existing uterine sarcoma.

Physicians who receive higher reimbursements for routine office visits are more likely to perform cancer screening tests on Medicaid beneficiaries, according to a new study in Cancer.

The ACO and Emerging Healthcare Delivery Coalition, an initiative of The American Journal of Managed Care, held its most recent WebEx session this week. Participants discussed new strategies and technologies that both employers and healthcare organizations can use to get patients to take ownership over their own care.

Few employers are planning to eliminate their health benefits in 2015, but they are still looking to make noticeable changes, according to a report from the Employee Benefit Research Institute.

The study, published in PNAS, identified a gene whose expression could be used as a prognostic indicator and could direct treatment in breast cancer patients.

Amid last week's news that CMS had miscalculated the number of enrollees under the Affordable Care Act was a quieter announcement that the agency had appointed a chief data office to improve transparency, among other tasks.

The deadline for eligible hospitals and critical access hospitals to attest to meeting meaningful use requirements has been pushed back a full month, according to CMS.

Genentech's decision to use a handful of specialty drug distributors instead of wholesalers for the distribution of the most commonly used anticancer medications has raised concerns of availability and cost.

The large retrospective study, conducted in 9.8 million men, identified a strong association between obesity and the development of an advanced and more aggressive form of the disease.

In the first 2 years of the Affordable Care Act, open enrollment has run for 2 different time periods, and HHS is looking to set a fixed date for future years. Plus, it offers a solution to automatic re-enrollment.

The monoclonal antibody,a c-Met inhibitor, was being tested in advanced gastric cancer patients following it's revival 2 years back.

The disclosure that a calculation error caused the Obama administration to add an extra 400,000 people to ACA enrollment figures for months puts a dent in the 2015 open enrollment, in part because it fits a narrative of a lack of transparency for reporters who cover the administration.

In the update, the FDA is now asking the device manufacturers to include a black box warning and contraindications, to warn both providers and patients of possible health risks with the procedure.

This article in The New York Times details the reasons why private oncology practices are being forced to consolidate to stay afloat.

Laws allowing terminal patients to try drugs not approved by the FDA have passed in five states, but experts question their efficacy.

The study, published in Nature Medicine, identified a small molecule inhibitor that increases histone methylation, compensating for the reduced methylation caused by mutation in the H3F3A gene, resulting in gliomas.

The leaders of the United Nations and the World Health Organization expressed renewed alarm on Friday about Ebola's tenacity in Africa and, in particular, its potential to ravage a fourth country, Mali, where they said hundreds of people had been exposed to an infected cleric who died last month.