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In a pair of interviews, experts discuss neutropenia resulting from treatment of metastatic breast cancer with CDK4/6 inhibitors.

Every week, The American Journal of Managed Care® recaps the top managed care news of the week, and you can now listen to it on our podcast, Managed Care Cast.

The Tax Cuts and Jobs Act introduced this week by House Ways and Means Committee Chairman Kevin Brady, R-Texas, proposes to lower individual tax rates for low- and middle-income Americans, increase the standard deduction, and add a new family tax credit, but the proposed legislation also has far-reaching implications for healthcare.

New research shows that eliminating Treg cells that prevent the cancer-fighting effect of an immunotherapy treatment doesn't actually end their suppressive qualities.

Following the transition year and ahead of the full implementation in year 3, CMS made provisions to the Quality Payment Program to make it easier for clinicians to participate in the program, reduce burden, and to get clincians ready for full implementation.

The House of Representatives passed a bill to fund the Children's Health Insurance Program (CHIP) for the next 5 years, but a lack of Democratic support means the bill's future in the Senate is unclear.

The former CMS administrator, who coined the term the Triple Aim, spoke about what he sees ahead in technology and how uncertainty is affecting the healthcare quality movement.

At the Community Oncology Alliance's Payer Exchange Summit VII: Oncology Payment Reform, practices shared their challenges and successes in the second year participating in the Oncology Care Model.

CMS officials addressed a key concern that groups offering the Diabetes Prevention Program would bear too much financial risk, but they were unmoved on requests to let beneficiaries try the program more than once in a lifetime.

This week, the top managed care news included the first day of open enrollment; data from CMS that indicate the progress accountable care organizations are making; and findings that most people with obesity aren't get screened for it or getting care.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

A new study questions the use of stents in certain patients; the House is expected to pass CHIP funding, but how to pay for it continues to be debated; and nearly all older, poorer people will have access to cheaper ACA plans in 2018.

Increased fiber, especially from cereal, intake after the diagnosis of non-metastatic colorectal cancer (CRC) is associated with lower CRC-specific and overall mortality.

The reform will adjust payment for drugs purchased through the program, relieve some burden for rural hospitals, and exempt rural sole community hospitals, certain cancer hospitals, and children's hospitals.

The Institute for Clinical and Economic Review (ICER) has announced the receipt a 3-year grant, totaling $13.9 million, from the Laura and John Arnold Foundation (LJAF).

The more a person is around cigarette smoke, the more likely he or she is to have atopic dermatitis.

New vaccine demonstrated positive results in treating psoriasis and cat allergy models, and may have potential to protect against Alzheimer disease.

While current, prior, and change in the Kansas City Cardiomyopathy Questionnaire score were all significnatly associated with lower risk of mortality and heart failure hospitalization in isolation, when the current score was included with either prior or change score, only the current score was significantly associated with lower risk for all-cause mortality.

Black men have the highest prevalence of intracranial atherosclerotic disease (ICAD) and the highest frequency of multiple plaques, a new study has found.

Bayer has announced the FDA’s acceptance of its Biologics License Application (BLA) for BAY94-9027 for the treatment of hemophilia A in adults and adolescents aged 12 years or older.

Previous studies have revealed a potential connection between chronic inflammatory conditions and the predisposition of chronic obstructive pulmonary disease (COPD), and a new study has found that patients with rheumatoid arthritis (RA) are associated with a greater risk of COPD hospitalization compared to the general population.

Mantle cell lymphoma is an aggressive type of non-Hodgkin lymphoma. Acalabrutinib (Calquence) is a kinase inhibitor that works by blocking an enzyme the cancer needs to multiply and spread.

Drug-pricing collution lawsuit widens to include more companies and drugs; New Jersey and Alaska also file lawsuits against Purdue Pharma for opioid marketing tactics; and the preterm birth rate in the United States increases.

The FDA has granted Priority Review designation for Eli Lilly and Company’s New Drug Application (NDA) for Verzenio (abemaciclib), a cyclindependent kinase 4 and 6 inhibitor for metastatic breast cancer. The decision was based on the MONARCH 3 study, which examined abemaciclib as an initial endocrine-based therapy.

Whether consumers use HealthCare.gov or a state exchange, this year’s enrollment cycle—the first year of Obamacare without Barack Obama—promises to be different. Some consumers will see premiums soar, while others will pay next to nothing,

Novartis has filed for an expanded indication for its chimeric antigen receptor T-cell treatment, tisagenlecleucel (Kymriah), for use in patients with diffuse large B-cell lymphoma (DLBCL), the most common form of non-Hodgkin’s lymphoma.

Strong chemotherapy may be part of the treatment plan for patients diagnosed with cancer, but it also comes with risks. A new campaign will empower patients with cancer to better understand and navigate risks such as febrile neutropenia that are associated with strong chemotherapy.

Results of the 70-gene signature assay strongly influence physician's treatment recomendations for patients with early breast cancer who were classified as intermediate risk by the 21-gene assay.