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Researchers from Massachusetts General Hospital and the Broad institute of MIT and Harvard recently identified specific states of cytotoxic CD8+ T cells that are associated with patient response to checkpoint immunotherapy for melanoma.

Retraction and republication: The JAMA article referenced in this story was retracted and republished on October 8, 2019. Please refer to the updated findings here.

Systemic lupus erythematosus, characterized by systemic inflammation in multiple organs, has a higher probability of being diagnosed in women who experienced emotional or physical abuse when growing up, according to a study presented at the 2018 American College of Rheumatology (ACR)/The Association of Rheumatology Health Professionals Annual Meeting.

A landmark moment in the world’s efforts to respond to the Ebola crisis is set to begin in the Democratic Republic of the Congo as clinical trials of an experimental therapy begin; after the National Rifle Association (NRA) posted a mocking tweet to physicians about gun violence, doctors responded in kind on Twitter; House Minority Leader Nancy Pelosi, D-California, said she is "staying on as Speaker" to protect the Affordable Care Act (ACA).

The Global Burden of Disease Study has ranked low back pain as a leading cause of disability worldwide, and the Lancet Low Back Pain Series Working Group has recommended that researchers and policy makers develop and implement strategies to identify and educate patients with low back pain who are at risk of persistence of pain and disability.

Data and collaboration are necessary ingredients to succeed in the transition to value-based care models, and the money saved under these models will create room to pay for unconventional therapies and services in healthcare, according to panelists at The Institute for Value-Based Medicine meeting in Seattle, Washington.

A new study in Chest has identified a correlation between electronic nicotine delivery systems (ENDS) and asthma symptoms in youth. The association was independent of cigarette smoking and ENDS use and exposure to secondhand cigarette smoke.

Many headache specialists are not satisfied with the care their patients receive in the emergency department (ED), demonstrating the need for more standardized protocols for ED visits by patients with known headache disorders, according to a new study.

Results presented at the American Heart Association in Chicago provided the strongest evidence to date on what heart failure specialists have discussed for several years now: the possibility that SGLT2 inhibitors might be used to prevent heart failure in patients with type 2 diabetes.

A recent review of alendronate for the treatment of glucocorticoid-induced osteoporosis (GIO) found that it significantly increased bone mineral density of the lumbar spine and femoral neck in patients with GIO, but does not appear to reduce the risk of fractures.

The FDA approved revefenacin (Yupelri), the first once-a-day nebulized bronchodilator for the treatment of chronic obstructive pulmonary disease (COPD).

Family-centered pediatric advance care planning increased and maintained agreement about goals of care longitudinally, which lowered adolescents’ physical symptoms and suffering.

A survey of nearly 700 people, each with at least $35,000 in household income, found that more than half of respondents are concerned about their ability to pay a medical bill of less than $1000, with 35% being concerned about paying a medical bill under $500.

Researchers recently reported findings from a study designed to determine patient attitudes about mammographic reporting of breast arterial calcification (BAC), result of the BAC communication, and subsequent action.

Preliminary data from a new study has demonstrated that pre-emptive administration of pan-genotypic, direct-acting antiviral therapy prevents hepatitis C virus (HCV) infection in HCV-negative cardiac transplant patients receiving donor hearts infected with the virus.

Progress in health around the globe has stagnated in some countries and gotten worse in others as the world faced increases in conflict and terrorism, epidemics, and noncommunicable diseases, according to global disease estimates published in The Lancet.

Seeking to determine how FN is managed in most referral hospitals in Iran, researchers studied patients hospitalized during a 6-month period, also taking into account characteristics of FN patients and the risk factors associated with FN development.

This week, the top managed care stories included Medicaid expansion wins at the ballot box; new melanoma guidelines that promote recommended treatments and discuss genetic testing; research found high blood pressure in young adults predicts future cardiovascular events.

Nonalcoholic fatty liver disease (NAFLD) has many identifiable risk factors and inflammatory biomarkers that are linked to osteoporosis, according to the results of a recent review.

In addition to voting for representatives whom people thought would align with their healthcare views, voters in multiple states were faced with ballot measures related to healthcare on November 6. Here are 5 healthcare ballot measures and how they fared in the 2018 midterm elections.

Treatments with therapeutic phlebotomy and hydroxyurea are associated with improved overall survival and decreased risk of thrombosis in older patients with polycythemia vera, according to a recent retrospective cohort study published in Blood Advances.

The FDA is planning on imposing severe restrictions on the sale of e-cigarette products as soon as next week; marijuana was a hit with voters in the midterm election; HHS is recommending a ban on the chemicals in kratom that would make the herb as illegal as heroin or LSD.

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Modifiable factors, including lower caloric intake, greater physical activity, and smoking cessation, have been associated with recovery from metabolic syndrome, according to the results recently published following a multiethnic study.

Data from a post hoc analysis is adding to positive literature on vagus nerve stimulation, concluding that the treatment quickly and consistently reduced pain intensity while decreasing rescue medication use among patients with episodic migraine.

What does it take to achieve member-centric, value-based care in population health? At a conference in New Jersey on Thursday, speakers talked about using partnerships and data to solve challenges, especially ones made worse by poor social determinants of health.

Citing the low level of reporting and subsequent drop of 8462 individuals from coverage, the Medicaid and CHIP Payment and Access Commission (MACPAC) said that the current process is likely not structured in a way that provides enrollees an opportunity to succeed under the requirements and, as a result, is calling for a pause in disenrollments in order to make proper adjustments to the program.

The announcement is an about-face from earlier efforts that scrapped a cardiac care bundled payment program originally developed during the Obama administration.

Individuals who suffer from knee pain also may suffer from neuropathic-like knee pain (NKP)—a result of localized damage to the nervous system and nerve fibers around a joint. Recent research aimed to determine the prevalence and risk factors of NKP, finding that NKP is driven by central risk factors and may require unique prevention and treatment strategies.

The Trump administration will allow religious groups, nonprofits, small businesses, and some other employers to opt out of providing birth control coverage for their employees; an analysis of over 50 million family trees finds that genes have little impact on life span; and women who wake up early have a lower risk of developing breast cancer.