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EMPRISE (Empagliflozin Comparative Effectiveness and Safety) will examine 5 years of real-world data on empagliflozin, which is sold as Jardiance by Eli Lilly and Boehringer Ingelheim. The study is comparing data on empagliflozin with that for dipeptidyl peptidase 4 (DPP-4) inhibitors. This latest interim analysis also features a cohort comparison with glucagon-like peptide 1 (GLP-1) receptor agonists.

Precision medicine may offer new hope to children with high-risk cancer, but only if families and healthcare professionals are fully educated on the benefits and limitations of precision medicine trials, according to a study in Journal of Clinical Oncology.

Tumor inflammatory response is significantly associated with poor prognosis in patients with multiple myeloma.

California is suing Juul Labs for their role in the youth vaping crisis; a lack of clean water and plumbing was shown to disproportionately affect Native Americans; a chemical plant is passing the permit process in a Louisiana area already dubbed “cancer alley.”

It has now become commonplace for families in America to struggle with their ability to keep children as healthy as possible due to factors related to social determinants of health, according to a new survey.

A recent review examined sleep-related disorders linked to neurology and psychiatry, noting that the disorders degrade quality of life and functional ability, and recommended that when taking a patient history, specific questions are needed to probe the exact symptoms so as to enable strategic treatments.

After saying he would back a ban on flavored vapes, President Trump now says he wants to study the issue more; the FDA approved Novartis’ crizanlizumab (Adakveo) as both monotherapy and in combination for patients 16 years or older with sickle cell disease; the Federal Trade Commission will allow Bristol-Myers Squibb to purchase Celgene for $74 billion in cash and stocks.

A longitudinal assessment of the cost-effectiveness of erenumab as a treatment for migraine exhibited higher patient utility when compared with placebo, according to study findings published this week.

Genomic profiling of tumors has become standard in oncology, but tumors in children often do not have actionable DNA aberrations, requiring another way to effectively target treatment for these patients. A study in JAMA Network Open found that RNA sequencing from pediatric and young adult patients may be a feasible approach.

Genetics plays a strong role in the the trajectory of the how psoriatic arthritis manifests in joint arthritis compared with skin disease.

Mercer’s 2019 National Survey of Employer-Sponsored Health Plans highlighted 3 key areas of focus for employers in 2019, which were balancing affordability and choice, empowering employees to improve their health through tech-enabled solutions, and addressing high-cost claims.

Clinical characteristics of women with chronic obstructive pulmonary disease (COPD) are important for primary care clinicians to consider in order to improve COPD awareness since women often go underdiagnosed, according to results from a recent study.

A recent study, published by JMIR Research Protocols, demonstrated the effectiveness of implementing a digital HIV care navigation intervention for young racial and ethnic minority men and transwomen.

A study investigating the cardiovascular responses to nitroglycerin in migraine found that migraineurs who developed a migraine-like attack in response to nitroglycerin demonstrated greater systemic cardiovascular responses compared with non-headache controls.

Two new rules from CMS will take steps to increase price transparency for the purpose of empowering patients and increasing competition in the market.

This week, the top managed care news included Medicaid tightening the reins on supplemental payments; employers needing more data to control benefit costs; experts saying prior authorization mostly burdens patients.

Multiple sclerosis (MS) is known to be associated with lower health-related quality of life, and a new study adds evidence that depression and fatigue are the major drivers of this relationship.

Adult patients with beta thalassemia will now have an FDA-approved treatment available with luspatercept-aamt (Reblozyl). The therapy treats the rare inherited blood disorder, which requires patients to have regular red blood cell transfusions.

A recent study in the International Journal of Women’s Dermatology described the complex interplay of sex hormones in the pathways of metabolic syndrome (MetS) in pre- and postmenopausal women and how clinicians should be aware of the multiple factors of MetS.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

An FDA committee unanimously agreed to expand the indication for Vascepa to include cardiovascular prevention; the number of enrollments through the HealthCare.gov marketplace has decreased 20% from last year; Dollar Tree has received a warning for selling medications imported from foreign manufacturers with safety violations.

There are substantial reductions in income over a lifetime for patients with sickle cell disease owing to early mortality, according to a new study that seeks to provide a better understanding of the condition from both the patient point of view as well as a societal point of view.

The Leap Motion Controller system used with serious games may be an effective option for a rehabilitation tool for improving coordination, speed of movements, and fine upper limb dexterity in patients with Parkinson disease, according to a recent study, published by the Journal of NeuroEngineering and Rehabilitation.

The November issue of The American Journal of Managed Care® (AJMC®) included studies on a kidney disease intervention, perceptions of alternative financing models, population health screening, and more. Here are 5 findings from research published in the issue.

In Australia, adults who are female, single, middle-aged, and have lower levels of education are more likely to experience less-than-optimal sleep, according to a recent study.

Called Diabetes Can Break Your Heart, the initiative seeks to get doctors and patients talking about the connection between diabetes and heart failure, so that symptoms are not missed and treatment that could prevent heart failure occurs early. A Diabetes Heartbreaker tour, which will feature a virtual reality experience with immersive technology, will kick off this weekend at the American Heart Association Scientific Sessions in Philadelphia.

Researchers aim to eliminate leukemia stem cells safely.

Solera announced this week that the company has expanded its relationship with Blue Mesa Health to offer a Spanish-language Diabetes Prevention Program (DPP) Transformemos as a covered California Medicaid (Medi-Cal) member benefit.

A team of researchers led by Memorial Sloan-Kettering Cancer Center Thursday published work describing how they used machine learning, a form of artificial intelligence (AI), to predict tumor type from targeted DNA sequence data to predict tissue of origin, in a finding that may have implications to improve diagnostic and clinical care.

Financial assistance provided to patients in California who require dialysis is being threatened amid a new state law; WHO to certify insulins to curb rising prices; CDC warns of rising drug-resistant superbug threat.