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A study presented at the 61st American Society of Hematology (ASH) Annual Meeting and Exposition in Orlando, Florida, discussed the first report of next-generation sequencing (NGS) to test for minimal disease response (MRD) after the combination of ibrutinib plus fludarabine, cyclophosphamide, and rituximab (iFCR) in chronic lymphocytic leukemia (CLL).

More treatments are needed for the 100 million individuals worldwide affected by psoriasis. Researchers from Brigham and Women's Hospital and the Harvard Stem Cell Institute have discovered a possible source of the skin thickening that may be triggered by dysregulated stem cells.

Ibrutinib, an FDA approved treatment with generally high response rates, can be resisted by some patients.

The study aimed to assess the prevalence of expiratory flow limitation in patients who require mechanical ventilation for acute respiratory failure.

A regular sleep schedule may decrease obesity risks, says an Italian study.

The agency said this was the first such approval, as the purified omega-3 fatty acid is now approved to be used alongside statins to treat elevated cholesterol levels and cut the risk of events such as heart attacks or strokes. The drug was first approved in 2012 for patients with elevated triglycerides.

Governor Henry McMaster, a Republican, announced the waiver plan at an event in Greenville, South Carolina, with CMS Administrator Seema Verma by his side. Some observers see Verma’s promotion of Medicaid work rules in the face of court challenges as a key to her political survival in her feud with HHS Secretary Alex Azar.

Physician and nurse interventions are the most effective means of promoting influenza vaccinations among patients with chronic obstructive pulmonary disease (COPD), according to the results of a pilot project.

The link connecting gut bacteria and psoriasis is inflammation, the authors said.

Chimeric antigen receptor (CAR) T cells are lymphocytes genetically engineered to recognize and bind to specific proteins on cancer cells. Studies are currently underway for applications in other fields.

The December issue of The American Journal of Managed Care® (AJMC®) included studies on out-of-network cost sharing, unhealthy alcohol use, patient health literacy, and more. Here are 5 findings from research published in the issue.

Speaker Nancy Pelosi’s, D-California, drug bill passes in the House; the FDA approves Vyondys 53, from Sarepta Therapeutics, to treat Duchenne muscular dystrophy; San Francisco tackles homelessness, mental illness, and substance abuse.

The results are sure to generate interest as heart failure with preserved ejection fraction lacks treatment options, but that could change as results are expected in outcomes trials that are studying sodium glucose co-transporter 2 inhibitors in heart failure, both with preserved and reduced ejection fraction.

This week, the top managed care stories included the White House seeking a truce between CMS Administrator Seema Verma and HHS Secretary Alex Azar; Sanofi will shift its focus from diabetes to cancer drugs; results highlight real-world evidence of chimeric antigen receptor T-cell therapies.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

More than 7 months after Scott Gottlieb, MD, resigned from his position as FDA commissioner, the Senate confirmed Stephen Hahn, MD, FASTRO, to be the next head of the agency.

Migraines increase the risk of asthma, and asthma is also associated with an elevated risk of migraine, according to new research.

Dopamine receptor D3 (DRD3) signaling regulates the dynamic of the acquisition of pro-inflammatory and anti-inflammatory features by astrocytes and microglia, favoring microglial activation and promoting neuroinflammation—the pathogenic process leading to neurodegeneration in many disorders, including Parkinson disease, according to a recent study.

In PwC Health Research Institute’s report, “Top health industry issues of 2020: Will digital start to show an ROI?” researchers highlighted the forces that will most powerfully affect the health industry in 2020, with a chief focus on the concern emerging from revisions to overseas tax provisions.

Hereditary transthyretin amyloid cardiomyopathy, which is caused by a genetic variant significantly associated with heart failure in individuals of African descent, is underdiagnosed, according to a new study published in JAMA.

There was a 37% increase in childhood cancer survival between 1975 and 2010. With more children receiving chemotherapy and radiation to treat their diseases, leading to more survivors, awareness has grown of the belated effects of those treatments once patients reach adulthood.

The HHS’ Office of the Inspector General (OIG) released a report that says Medicare Advantage (MA) plans received an estimated $6.7 billion in 2017 after adding diagnoses to patients' files that were not supported by their medical records; more Americans are dying at home rather than in hospitals or nursing homes; the FDA warned Alkermes, maker of Vivitrol, a long-acting antiaddiction medication, that its printed advertisement does not include the risk of an increased chance of a “potentially fatal” opioid overdose as the effects wear off.

A second study, slated for next year, will continue these infants on antiretroviral treatment with 2 experimental monoclonal antibodies, hoping the medications produce viral suppression—and testing the effects of temporarily stopping them—so that they don’t have to eventually initiate the standard triplet therapy that most older patients typically take. For adults, most treatments for HIV come from the cancer field, and are inflammatory, and are not safe enough to apply in children. An ongoing debate is when is it appropriate to begin these therapies in children.

CMS Administrator Seema Verma and HHS Secretary Alex Azar told to work out their differences; the debate continues on whether health insurance coverage affects mortality rates; Facebook is accused of misleading the public about the benefits of pre-exposure prophylaxis (PrEP).

A recent study published in The New England Journal of Medicine says that women with dense breast tissue who undergo supplemental magnetic resonance imaging (MRI) tests have lower rates of interval cancers than those who receive only mammography tests, although they also had higher rates of false positive tests.

Two migraine prevention agents, cinnarizine and sodium valproate, were shown to be safe and effective in reducing incidence and severity of migraine within children and adolescents, according to study findings. Safety findings must be weighed alongside warnings from European regulators about the risks of valproate for girls and adolescent women who could bear children in the future.

The painless procedure is still in its experimental stages; however, it is inexpensive and safe, and the equipment is portable.

Sanofi is ending research efforts in diabetes and cardiovascular diseases; the White House endorsed an emerging bipartisan agreement on legislation aimed at curbing rising healthcare costs by targeting surprise medical billing; the Supreme Court will hear oral arguments in a case involving whether the federal government owes insurers $12 billion in a dispute about risk corridor payments.

Although survival rates for multiple myeloma have improved as treatment options have increased, the disease remains incurable, and many patients stop current agents such as lenalidomide or bortezomib due to toxicity. Results of CANDOR involving a triple therapy were presented Tuesday at the 61st American Society of Hematology Annual Meeting and Exposition in Orlando, Florida.