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Metformin-based therapy may be an optimal first-line treatment for patients with type 2 diabetes (T2D) and low cardiovascular risk, according to a systematic review and network meta-analysis published in Annals of Internal Medicine.

The FDA approved Phesgo (pertuzumab/trastuzumab/hyaluronidase-zzxf) as a subcutaneous (SC) treatment for adult patients with metastatic human epidermal growth factor receptor 2 (HER2)-positive breast cancer or early-stage HER-2 positive disease. The treatment combines 2 monoclonal antibodies in a single SC injection.

Both frontline and nonfrontline health care workers were found to experience stark levels of stress and poor sleep quality amid the coronavirus disease 2019 (COVID-19) pandemic, with being female and having a professional background indicated as predictors of these effects, according to study findings.

In the United States, Gilead Sciences set the price for remdesivir, its antiviral drug that can shorten hospitalization stays for individuals ill with coronavirus disease 2019 (COVID-19), based on insurance factors, and is allowing generic drug makers to create the drug for less in low to middle income countries.

Being on an antiretroviral treatment (ART) regimen of tenofovir disoproxil fumarate/emtricitabine may lower the risk of HIV-positive individuals contracting coronavirus disease 2019 (COVID-19).

Aging and longer axial length are independent and significant risk factors for myopic maculopathy, according to a study published in JAMA Ophthalmology. The study also found the condition, which is the leading cause of irreversible visual impairment and blindness for middle-aged and older individuals, has a much higher prevalence rate in Japan compared with other Asian countries.

Female migraineurs tend to exhibit longer attack duration and greater frequency of nausea, vomiting, osmophobia, and vertigo/dizziness, compared with male migraineurs, according to a community-based study.

Lockdown because of coronavirus disease 2019 (COVID-19) is not an option in impoverished and war-torn countries; the FDA grants emergency use clearance to Danaher Corp's COVID-19 antibody test; strategizing amid misinformation spread on the pandemic.

Rita E. Numerof, PhD, is the president of Numerof & Associates, a firm that helps businesses across the healthcare sector define and implement strategies for winning in dynamic markets. For more than 25 years, she has helped executives understand the implications of an evolving healthcare market. Working with leaders in the healthcare space, she has consulted with everyone from top academic and community hospital systems, payers, and Fortune 500 pharmaceutical, device, and diagnostics companies. She is the coauthor of several books, most recently, "Bringing Value to Healthcare: Practical Steps for Getting to a Market-Based Model" (2016).

These findings highlighted that adherence to drugs is not the sole issue to address in patients with comorbidities also serving as vital factors in designing managed care plans.

While cognitive functions in patients with Parkinson disease were only slightly impacted by the coronavirus disease 2019, notable effects on urinary issues and fatigue may warrant adjustments to therapy, according to study findings.

Patients with B-cell non-Hodgkin lymphomas and B-cell acute lymphoblastic leukemia can benefit greatly from chimeric antigen receptor (CAR) T-cell therapy, but providing that therapy has become much more difficult in the age of coronavirus disease 2019 (COVID-19).

Patients between the ages of 18 and 39 who are diagnosed with solid-tumor cancers are more likely than the general population to have germline mutations that could make them more susceptible to secondary primary cancers, according to new research.

Having lower socioeconomic status, comorbidities, or being covered by Medicare was associated with less receipt of immunotherapy for stage III melanoma.

In its first briefing in 2 months, the White House Coronavirus Task Force addressed rising cases of coronavirus 2019 (COVID-19) and positive test rates across states in the South, as well as the new data that show the majority of new cases are occurring in younger Americans.

While biologics may have improved outcomes in rheumatoid arthritis (RA), they also have higher costs and adverse events, and patients are more likely to request dose reductions or drug holidays.

The use of disease-modifying therapy (DMT) was associated with a lower risk of hospitalization for patients with coronavirus disease 2019 (COVID-19), and neurological disability, age, and obesity were independent risk factors for more severe cases of infection for patients with multiple sclerosis (MS).

Coverage of our peer-reviewed research and news reporting in the health care and mainstream press.

There are thousands of rare diseases, but they each affect so few patients that diagnosis and treatment can be delayed by years. Researchers examined how machine learning has been studied in rare diseases and identified areas of opportunity where future studies can improve care and treatment of rare diseases.

This week, the top managed care news included CMS proposing rules for value-based contracting in Medicaid; claims data highlighting racial disparities in COVID-19 effects; an interview with Anthony Fauci, MD, on the progress made against HIV.

The CDC has updated its guidance as to who is at risk for more severe cases of coronavirus disease 2019 (COVID-19); Texas suspended its economic reopening in the wake of surging COVID-19 cases; HHS releases updated organ donation rules.

Minimal residual disease (MRD) status has been shown to be a better indicator of the prognosis of a patient with multiple myeloma (MM) than “complete remission.” Yet, it’s still not widely used in the clinic. A new article examines the problem.

Results from an analysis of patients with breast cancer and coronavirus disease 2019 (COVID-19), from Institut Curie hospitals in France, show that mortality is determined more by comorbidities than previous or current treatment for the cancer.

A review on the effects of Janus kinase (JAK) inhibitors for the treatment of myelofibrosis, including the first approved, ruxolitinib, and others currently in development.

A report, to appear in the September 2020 Health Affairs, says the losses could be higher, as much as $18 billion, if there is a second wave of infection in the fall or telehealth regulations eased at the start of the pandemic do not continue.

The Trump administration and Republican state attorneys general called on the Supreme Court to overturn the entire Affordable Care Act (ACA, also known as Obamacare). President Trump has endorsed repealing the ACA since his 2016 campaign, while Republican lawmakers have largely opposed the law since its inception in 2010.

Bayer AG agreed to settle the majority of claims alleging its product Roundup causes blood cancer; Census Bureau data show a historic demographic shift; a federal lawsuit claims Regeneron funneled millions of dollars to a charity.

The savings occurred even while more patients in the health system were enrolling in clinical trials, according to an abstract presented during the American Society of Clinical Oncology 2020 Virtual meeting.

A coauthor of the study said that if the noninvasive test was used more widely, before kidney cancers have spread, fewer people would die from the disease.