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Articles on advances in immuno-oncology and non-small cell lung cancer were popular with readers in the past year.

Chronic liver disease is on the rise and the burden is expected to increase in the future, both in the United States and around the world. These are the most-read articles about liver disease in 2021.

The new recommendations for systemic lupus erythematosus (SLE) use disease activity index scores and evaluator’s global assessment measures, but they do not include serology.

James Auran, MD, a professor of ophthalmology at Columbia University Irving Medical Center and president of the American Society of Ophthalmic Trauma, discusses how a lack of providers has created a crisis in the United States.

Psoriasis severity and treatment outcomes were found to differ across US geographic regions, in which the East South Central and West South Central regions were associated with the greatest frequencies of very severe disease burden and decreased likelihood of achieving targeted response within 6 months of initiating biologic therapy.

The most-read AJAC papers of 2021 analyze real-world programs to transform health care and provide insight into physician perspectives of health care and insurance.

An analysis uncovered racial, ethnic, and socioeconomic inequities regarding access to glucagon-like peptide-1 receptor agonists among US patients with diabetes.

This year's most-read inflammation articles included ones about Janus kinase inhibitors and the impact of biologics or systemic corticosteroids on severe COVID-19.

This year’s most-read articles on Fabry disease touched on advancements in therapy, health risks of the disease, and keys to improved diagnosis.

With legalization of cannabis across much of the United States and all of Canada, Don Sin, MD, FRCP, MPH, a professor of respiratory medicine at the University of British Columbia and head of the Centre of Heart Lung Innovation, St. Paul’s Hospital, has concerns about the effect of wider cannabis usage on chronic obstructive pulmonary disease (COPD) in future decades.

Data from the GLOW study of minimal residual disease evaluation following chemotherapy for chronic lymphocytic leukemia (CLL) show the kinase inhibitor/B-cell lymphoma-2 inhibitor pair produced superior outcomes compared with the alkylating agent/monoclonal antibody combination.

Results of a meta-analysis and systematic review indicate rosacea is significantly associated with depression and anxiety.

This year's most-read migraine articles covered a range of topics, such as new causes of migraine, its link to bipolar disorder, and COVID-19's impact on existing migraine.

Behavioral cough therapy should be used as early intervention, said Laurie Slovarp, PhD, CCC-SLP, associate professor in the School of Speech, Language, Hearing, and Occupational Sciences at University of Montana.

Despite being the seventh adalimumab biosimilar approved in the United States, there are none on the market yet.

Readers were most interested in articles about cost of therapy, drug efficacy, and a unique case related to COVID-19.

Michael Thorpy, MD, director, Sleep-Wake Disorders Center, Montefiore, and professor of neurology, Albert Einstein College of Medicine, discusses treatment implications for clinicians managing chronic insomnia and potential comorbid conditions.

Marijuana use by people with HIV during pregnancy and post partum increased over time, with the prevalence of general substance use increasing more post partum.

Epigenetics has a role in choosing the right medicine in lung cancer, artificial intelligence can predict outcomes in a highly aggressive cancer, and more.

In 2021, the articles published in the peer-reviewed The American Journal of Managed Care® (AJMC®) explored responses to the COVID-19 pandemic, the potential of health policy reforms, the importance of population health, and much more.

This year’s most-read articles on Medicare covered topics including accountable care organizations, value-based payment, and star ratings.

A study of the adult Korean population found high salt intake was associated with an increase in major adverse cardiovascular events (MACE) in patients with rheumatoid arthritis (RA).

Kimberly Westrich, MA, vice president of health services research at the National Pharmaceutical Council, discusses value-based benefit design strategies for high-deductible health plans.

A study found significant differences in the therapeutic and diagnostic approaches to atopic dermatitis used by allergists, dermatologists, and pediatricians, and those recommended by guidelines.

Research using data from the ASH Research Collaborative COVID-19 Registry for Hematology identified risk factors for severe infection and mortality for patients with blood cancers who were infected with COVID-19.

Research on belimumab, mean platelet volume, and how lupus is linked with other autoimmune diseases appeared in AJMC.com's top 5 most-read lupus articles of 2021.

Adriaan Voors, MD, professor of cardiology and director of the Heart Failure Clinic, University Medical Center Groningen, the Netherlands, explains why patients provided sodium-glucose co-transporter 2 (SGLT2) inhibitors in hospitals may be unable to continue the medication after discharge.

Risk factors for more severe COVID-19 and potentially protective factors appear on this year’s list of most-read clinical COVID-19 articles.

This year’s most-read articles on endocrinology posted at AJMC.com were concentrated in 3 areas: hormone therapy, treatment for growth hormone deficiency among pediatric patients, and outcomes among women with polycystic ovary syndrome.

The FDA this week approved cabotegravir (Apretude), the first and only long-acting injectable pre-exposure prophylaxis option to reduce the risk of sexually acquired HIV-1.