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Data on nusinersen’s safety profile in adult patients are more limited than in infant and adolescent patients, but a recent study showed positive results based on cerebrospinal fluid and blood sample parameters.

Robert A. Gabbay, MD, PhD, chief scientific and medical officer at the American Diabetes Association, explains why clinical trials need to be inclusive and how the Health Equity Now initiative is working to recruit more diverse populations with diabetes.

Across all studies included, observed-to-expected ratios showed that White and Asian patients were overrepresented while Black patients, Hispanic patients, and American Indian/Alaskan Native patients were underrepresented.

Theresa Juday, RPh, director, Specialty Product Development, CVS Health, speaks about the barriers affecting uptake of cognitive behavioral therapy (CBT) as a first-line treatment for insomnia.

Seth Martin, MD, MHS, associate professor of medicine at Johns Hopkins University and co-director of the Center for Mobile Technologies to Achieve Equity in Cardiovascular Health (mTECH Center), gives a preview of his presentation on digital divides at the American Heart Association (AHA) Scientific Sessions 2021.

Study findings presented at the American Society of Ophthalmic Plastic & Reconstructive Surgery's 2021 Fall Scientific Symposium detail the benefits of teprotumumab for thyroid eye disease.

The World Health Organization and CDC warn of the potential for measles outbreaks; the National Institutes of Health (NIH) and Moderna battle over patent rights to Moderna’s COVID-19 vaccine; a new Kaiser Family Foundation shows employers have increased mental health care offerings.

Although the authors say their findings shed light on possible disruptions to insulin supply during COVID-19, they note they could not adjust for those with diabetes who died.

Michael E. Chernew, PhD, co-editor-in-chief of The American Journal of Managed Care®, discussed cost and sustainability issues specific to commercial insurance, Medicare, and Medicaid at the National Alliance 2021 Annual Forum held in a hybrid format in Washington, DC.

States are turning to alternative payment models to improve outcomes and reduce health care expenditures, representing a critical step forward specifically for the US maternal health crisis.

A recent review highlighted the importance of managing cardiovascular risk factors in patients with Fabry disease versus the general population.

A recent review examined the significant physical, social, emotional, and financial impacts of acid sphingomyelinase deficiency (ASMD) on patients and caregivers from an overall lifestyle standpoint

Drug use, serum albumin, and total number of lesions may serve as independent factors influencing the degree of disability in patients with multiple sclerosis (MS), investigators of a retrospective analysis concluded.

Access to antiretroviral treatment was not disrupted, despite decreased in-person services during the pandemic.

The share of patients meeting the definition of polypharmacy for the condition of overactive bladder declined from 2006 to 2017, but the phenomenon was still prevalent in women and patients in nursing homes, according to a recent study.

Adults with atopic dermatitis were shown to be at lower risk of developing asthma if they were vaccinated against influenza, particularly those who adhered to yearly shots.

Robert A. Gabbay, MD, PhD, chief scientific and medical officer at the American Diabetes Association, discusses COVID-19 vaccinations among people with diabetes as they have been disproportionally affected by the pandemic.

Tiffany Powell-Wiley, MD, MPH, a Stadtman investigator and chief of the Social Determinants of Obesity and Cardiovascular Risk Laboratory at the National Heart, Lung, and Blood Institute, with a joint appointment at the National Institute on Minority Health and Health Disparities, discusses ongoing trials and the American Heart Association’s Scientific Statement on social determinants of obesity and cardiovascular disease.

The Supreme Court of Oklahoma ruled that Johnson & Johnson cannot be held liable for the state’s opioid crisis; a trial found the psychedelic drug psilocybin may be a highly efficacious therapy for treatment-resistant depression; people who went to bed at midnight or later had a 25% greater risk of cardiovascular disease.

An evaluation of data from the Global Burden of Disease found that nonalcoholic fatty liver disease (NAFLD) is a main driver of chronic liver disease and has increased among adolescents and young adults.

Outcomes of in-hospital mortality, 7-day mortality, and emergency department length of stay were investigated among a cohort of patients with acute heart failure and hypercapnia, or excessive levels of CO2 in the blood.

The report suggests childcare concerns could be a significant factor keeping Black women from attending weekly workshops.

If FDA approved for children, secukinumab (Cosentyx) will be the first biologic treatment for children in the US living with enthesitis-related arthritis.

An overview of activities at the FDA to promote the use of biosimilars was presented by Jacqueline Corrigan-Curay, JD, MD, principal deputy center director for the Center for Drug Evaluation and Research (CDER) at the FDA.

Findings of a real-world, single-center study indicated that apremilast was effective and safe long-term in the treatment of moderate-to-severe plaque psoriasis.

This cohort study of women living with HIV, pregnant and not pregnant, investigated outcomes related to engagement in HIV care following a live birth.

The analysis showed biomarkers that persisted despite the presence or absence of type-2 inflammation.

On this episode of Managed Care Cast, we speak with Abi Sundaramoorthy, MD, MBA, executive vice president of clinical enterprise at Somatus, on fragmented care in chronic kidney disease, its disproportionate impact on minority communities, and the potential of value-based arrangements to address disparities and promote preventive, effective care.

The parameter could potentially help clinicians zero in on the cause of left ventricular hypertrophy.

Pfizer and BioNTech expect to seek emergency use authorization for their COVID-19 booster vaccine in all adults 18 years and older; the Biden administration urges appeals court to not block employer vaccine mandate; nearly 8 in 10 Americans believe or are unsure of false COVID-19 information.