Dr Thomas Roth, PhD, presented on the evolution of our understanding of insomnia, and the importance of insomnia in the context of other disease states. Roth noted that insomnia is primarily a disorder of increased wakefulness from a pathophysiologic standpoint, and presented data to support this. Presenting the effect of improved sleep on diseases such as depression, worker productivity, and cardiovascular disease, Roth revealed rich prospects for the future of sleep medicine in treating a variety of disorders.