Myelodysplastic Syndromes

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Orca-T shows promise to reduce rehospitalization and improve outcomes in MDS and acute leukemias.| Image credit: Eleni - stock.adobe.com

Reduced Rehospitalizations and Potential Cost Savings With Orca-T for Acute Leukemia, MDS

By Mary Caffrey
Caspian Oliai, MD, MS

April 11th 2025

Orca-T showed lower rates of graft-vs-host disease or infection compared with allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome (MDS) or acute leukemias in the Precision-T trial, Caspian Oliai, MD, MS, UCLA Bone Marrow Transplantation Stem Cell Processing Center, said.

ESA treatment before or early after regular transfusion therapy improved OS In lower-risk MDS, a new study found. | Image credit: MdBabul - stock.adobe.com

ESA Treatment Improves OS in Lower-Risk MDS

By Rose McNulty

March 28th 2025

A newly developed MDS scoring system has similar diagnostic accuracy to a more established, but also more elaborate, system, a new study found. | Image credit: syahrir - stock.adobe.com

ELN Scoring System Shows Similar Accuracy to iFS for MDS Diagnosis

By Jared Kaltwasser

March 26th 2025

Orca-T is manufactured with highly purified regulatory T cells, hematopoietic stem cells, and conventional T cells from peripheral blood from matched donors. | Image credit: fotogurmespb - stock.adobe.com.jpg

Orca-T Immunotherapy Improves cGVHD-Free Survival in ALL, AML, MDS

By Rose McNulty

March 20th 2025

In patients with MDS and AML, the researchers found impaired neutrophil subset distribution compared with healthy individuals. | Image credit: keetazalay - stock.adobe.com

Neutrophil Subset Changes Give Insight Into First Mechanisms of MDS, AML

By Rose McNulty

March 14th 2025

More News

Researchers Develop Improved Flow Cytometric Score for MDS Diagnosis

January 16th 2021

Researchers Develop Improved Flow Cytometric Score for MDS Diagnosis

A flow cytometric score developed in 2012, which uses 4 parameters to distinguish low-grade myelodysplastic syndromes (MDS) from nonclonal cytopenias, is simple and practical for screening patients with MDS, according to research published in the American Journal of Translational Research.

Analysis Reveals High Cost of Discontinued HMA Treatment for MDS

January 15th 2021

Analysis Reveals High Cost of Discontinued HMA Treatment for MDS

New research underscores the substantial economic burden associated with early discontinuation of guideline-recommended hypomethylating agent (HMA) therapy among patients with refractory anemia with excess blasts, a diagnosis that substantially overlaps with higher-risk myelodysplastic syndrome (MDS).

PROs Used in Low-Risk MDS Found to Have Strong Face, Content Validity

January 9th 2021

PROs Used in Low-Risk MDS Found to Have Strong Face, Content Validity

A recent study evaluated the content validity of patient-reported outcome instruments used in low-risk myelodysplastic syndrome (MDS).

Study Finds IWG 2006 Response Criteria Valid in Patients With Higher-Risk MDS

January 7th 2021

Study Finds IWG 2006 Response Criteria Valid in Patients With Higher-Risk MDS

Complete response to first-line therapy, as determined by the International Working Group 2006 response criteria, can be used as a surrogate end point for overall survival in higher-risk patients with myelodysplastic syndromes (MDS), according to a study published in Cancer Medicine.

Is a New Classification and Prognosis System Possible for Myelodysplastic Syndromes?

January 2nd 2021

Is a New Classification and Prognosis System Possible for Myelodysplastic Syndromes?

Jaime Rosenberg

Integrating novel parameters into conventional risk stratification systems may better define patient subgroups in myelodysplastic syndromes (MDS), thus creating a more enhanced classification and prognostic scoring system for patients, say researchers.

Unanswered Questions Remain in Optimal Management of RBC Transfusions in MDS

January 1st 2021

Unanswered Questions Remain in Optimal Management of RBC Transfusions in MDS

Jaime Rosenberg

Questions remain about the optimal approach to transfusion management in myelodysplastic syndromes (MDS), particularly in the outpatient setting, leading a pair of researchers to review current evidence.

Heterogenous Nature of MDS Warrants Further Research, Review Finds

December 23rd 2020

Heterogenous Nature of MDS Warrants Further Research, Review Finds

Jaime Rosenberg

With a goal of moving toward more individualized therapeutic approaches, researchers said future advancements in understanding myelodysplastic syndrome (MDS) molecular mechanisms are needed to offer clinical decision making guidance.

Bone marrow cell

December 19th 2020

Gene Expression Signatures Linked With Response to HMA Treatment in Patients With MDS

Jaime Rosenberg

Their work may help to further understanding of the molecular mechanisms of hypomethylating agents (HMAs) and offer a guide for determining which patients are likely to respond to such treatment.

Target on leukemia cell

December 18th 2020

For Patients With HMA-Resistant MDS, What Are Their Options?

Jaime Rosenberg

For patients who are resistant to hypomethylating agent (HMA) treatment, there are no formal treatment recommendations, but several options, spanning from novel HMAs to chemotherapy, have been or are currently being studied in the setting.

Enlarged drop of blood

December 12th 2020

Study Finds Significant Survival Advantage for Patients With MDS Who Have HLA-Matched Donor for HCT

Jaime Rosenberg

The abstract, presented at the 2020 American Society of Hematology Annual Meeting and Exposition, found favorable overall survival and leukemia-free survival for these patients.

NCCN Adds Oral Decitabine, Cedazuridine Combo to MDS Guidelines

December 8th 2020

NCCN Adds Oral Decitabine, Cedazuridine Combo to MDS Guidelines

Inqovi is an orally administered, fixed-dose combination of the DNA hypomethylating agent, decitabine, and cedazuridine, an inhibitor of cytidine deaminase.

Dr Abby Statler Speaks on Eligibility Criteria Exclusions for MDS Clinical Trials

February 21st 2020

Dr Abby Statler Speaks on Eligibility Criteria Exclusions for MDS Clinical Trials

Our outcomes suggest that eligibility criteria for patients with MDS relevant to liver function, renal function, and comorbidities may be relaxed, especially for those who have minor renal function abnormalities who have shown to have similar clinical outcomes to those without such abnormalities, said Abby Statler, PhD, MPH, MA, research associate at Cleveland Clinic.

Chemotherapy for Solid Tumors Associated With Increased Risk of AML, MDS

December 28th 2018

Chemotherapy for Solid Tumors Associated With Increased Risk of AML, MDS

Laura Joszt, MA

Patients who are treated with chemotherapy for their solid tumors have an increased risk of therapy-related myelodysplastic syndrome and acute myeloid leukemia (tMDS/AML) despite advances in chemotherapy regimens, according to a new study in JAMA Oncology.

Early Data Suggests CC-486 Relatively Safe, Effective in Thrombocytopenic Patients With MDS

November 21st 2018

Early Data Suggests CC-486 Relatively Safe, Effective in Thrombocytopenic Patients With MDS

There have been few therapeutic options for treating thrombocytopenia in MDS patients. Now, early phase data suggest that CC-486 (oral azacytidine, an investigational drug sponsored by Celgene) is a relatively safe and effective treatment for thrombocytopenic patients with MDS.

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