Multiple Sclerosis

The AJMC® Multiple Sclerosis compendium is a comprehensive resource for clinical news and expert insights for the disabling disease that impacts the brain and spinal cord.

Latest News

BMI - Olivier Le Moal
Study Finds Obesity May Worsen Multiple Sclerosis: Genetic Analysis Points to Causal Link

November 21st 2024

A new study aimed at exploring the relationship between obesity and multiple sclerosis severity using genetic data finds that higher BMI and other obesity measures were associated with increased disability progression in patients with MS.

Doctor examining MRI images of multiple sclerosis MS | Image Credit: © New Africa - stock.adobe.com
Lesion Repair, Damage Processes Correlate With MS Disease Characteristics

November 11th 2024

Neurologic disease concept | image credit: ralwel - stock.adobe.com
Fexagratinib in MS Shows Promise for Human Use

November 9th 2024

MS word cloud | Image Credit: © arloo-stock.adobe.com
Exploring Metabolic Links to Cognitive Impairment in MS

November 8th 2024

Fingolimod | Image Credit: © María Pilar Martínez - stock.adobe.com
Fingolimod-Induced Heart Rate Slowing Tied to Parasympathetic Dominance in MS

October 26th 2024

Examining the Role of a Novel Class of Medications for the Management of Multiple Sclerosis

This video series provides an in-depth look at multiple sclerosis, covering its impact, pathophysiology, treatment strategies, unmet needs, patient satisfaction, and future research. Gain key insights into managing and understanding this condition.

This video series provides an in-depth look at multiple sclerosis, covering its impact, pathophysiology, treatment strategies, unmet needs, patient satisfaction, and future research. Gain valuable insights into managing and understanding this complex condition.
Continuing Medical Education
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November 21st 2024

Assessing the Treatment Landscape for Multiple Sclerosis to Better Individualize Care

1.5 Credits / Neurology
November 21st 2024

Exploring Transthyretin-Mediated Amyloidosis and Its Phenotypes: A Comprehensive Approach to Patient Treatment

1.5 Credits / Cardiology, Neurology, Rare Diseases
November 21st 2024

The Role of the Specialty Pharmacist in Optimizing Treatment for Amyotrophic Lateral Sclerosis: The Impact of Early Intervention, Patient-Centered Care, and Disease-Modifying Therapies in Slowing Disease Progression

1.0 Credit / Neurology
November 21st 2024

Advancing Targeted Therapies Aimed at Smoldering Disease in Multiple Sclerosis

1.0 Credit / Immunology, Neurology
November 21st 2024

The Economics of Transthyretin-Mediated Amyloidosis: Balancing Equity and Access in Resource Allocation

1 Credit / Cardiology, Neurology

More News

Fingolimod Significantly Reduces Relapse in MS Compared With Dimethyl Fumarate, Teriflunomide
February 2nd 2019

Fingolimod Significantly Reduces Relapse in MS Compared With Dimethyl Fumarate, Teriflunomide

Samantha DiGrande
A recent study sought to compare several available oral immunotherapies for the treatment of relapsing-remitting multiple sclerosis (MS).
Researchers Identify New Therapeutic Approach to Multiple Sclerosis With Sephin1
January 31st 2019

Researchers Identify New Therapeutic Approach to Multiple Sclerosis With Sephin1

Laura Joszt, MA
Sephin1 provided protective benefits that delayed loss of myelin and onset of debilitating disease in mouse models of multiple sclerosis.
Factors Associated With Speed of Multiple Sclerosis Diagnosis
January 26th 2019

Factors Associated With Speed of Multiple Sclerosis Diagnosis

Laura Joszt, MA
A new study examined what factors might prolong time from onset of symptoms to diagnosis of multiple sclerosis.
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January 26th 2019

Trends in Palliative Care Utilization in Patients With Multiple Sclerosis

Lee YJ, Yoo JW, Hua L, Kim PC, Kim SJ, Shen JJ. Ten-year trends of palliative care utilization associated with multiple sclerosis patients in the United States from 2005 to 2014. J Clin Neurosci. 2018, 58:13-19. doi: 10.1016/j.jocn.2018.10.082.
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January 26th 2019

Exploring Novel Reasons for Nonadherence to Disease-Modifying Therapies

Schoor R, Bruce A, Bruce J, et al. Reasons for nonadherence response to treatment in an adherence intervention trial for relapsing-remitting multiple sclerosis patients [published online November 28, 2018]. J Clin Psychol. 2018. doi: 10.1002/jclp.22725.
Identifying Standards for Timely Intervention and Treatment in Multiple Sclerosis
January 23rd 2019

Identifying Standards for Timely Intervention and Treatment in Multiple Sclerosis

Laura Joszt, MA
Prompt diagnosis and timely intervention is key in improving outcomes for patients with multiple sclerosis (MS). A new study in Multiple Sclerosis Journal outlines quality standards for timely, brain health–focused MS care.
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January 21st 2019

Exploring the Legal Use of Cannabis by Patients With Multiple Sclerosis

Weinkle L, Domen CH, Shelton I, Sillau S, Nair K, Alvarez E. Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal. Mult Scler Relat Disord. 2019, 27:383-390. doi: 10.1016/j.msard.2018.11.022.
Researchers Use Blood Test to Detect Preclinical Alzheimer Disease Signs
January 21st 2019

Researchers Use Blood Test to Detect Preclinical Alzheimer Disease Signs

Allison Inserro
Researchers used a blood test to look for biomarkers indicative of Alzheimer disease in a group of people with a genetic mutation for a familial form of the disease, and they said the test can predict differences about 16 years before affected patients are expected to begin showing symptoms. The hope is that a blood test could one day be used to identify brain disease for not only Alzheimer disease but also other neurodegenerative conditions, such as multiple sclerosis, traumatic brain injury, or stroke.
Can Rituximab Delay Disease Progression in SPMS?
January 19th 2019

Can Rituximab Delay Disease Progression in SPMS?

Samantha DiGrande
A recent study sought to identify whether disability progression among patients with secondary progressive multiple sclerosis (SPMS) treated with rituximab differs from patients who have never been treated with rituximab.
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January 19th 2019

Feasibility of Implementing a Tailored Exercise Program for Black Patients With Multiple Sclerosis

Kinnett-Hopkins D, Motl R. Results of a feasibility study of a patient informed, racially tailored home-based exercise program for black persons with multiple sclerosis. Contemp Clin Trials. 2018, 75:1-8. doi: 10.1016/j.cct.2018.10.009.
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January 19th 2019

Understanding the Relationship Among Fatigue, Sleep Hygiene Behaviors, and Symptoms of Multiple Sclerosis

Newland P, Lorenz RA, Smith JM, Dean E, Newland J, Cavazos P. The relationship among multiple sclerosis-related symptoms, sleep quality, sleep hygiene behaviors. J Neurosci Nurs. 2018, 51(1):37-42. doi: 10.1097/JNN.0000000000000409
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January 19th 2019

Double-Blinded Extension of the RADIANCE Trial Demonstrates the Efficacy and Safety of Ozanimod in Patients With Multiple Sclerosis

Cohen JA, Comi G, Arnold DL, et al RADIANCE Trial Investigators. Efficacy safety of ozanimod in multiple sclerosis: dose-blinded extension of a randomized phase II study [published online July 25, 2018]. Mult Scler. 2018:1352458518789884. doi: 10.1177/1352458518789884.
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January 19th 2019

Interferon-beta Versus Glatiramer Acetate as Initial Treatment for Multiple Sclerosis: Long-term Follow-up

Healy BC, Glanz BI, Zurawski JD, Mazzola M, Chitnis T, Weiner HL. Long-term follow-up for multiple sclerosis patients initially treated with interferon-beta, glatiramer acetate. J Neurol Sci. 2018, 394:127-131. doi: 10.1016/j.jns.2018.09.020.
Earlier Treatment With Disease-Modifying Therapies Decreases Risk of MS Progression
January 18th 2019

Earlier Treatment With Disease-Modifying Therapies Decreases Risk of MS Progression

Laura Joszt, MA
Treating patients with relapsing-remitting multiple sclerosis (MS) early with disease-modifying treatment can reduce the risk of conversion to secondary progressive MS.
Could Coffee and Caffeine Treat Fatigue in Patients With MS?
January 12th 2019

Could Coffee and Caffeine Treat Fatigue in Patients With MS?

Samantha DiGrande
Researchers hypothesized that because coffee and caffeine showed a beneficial effect on daytime tiredness in Parkinson disease, a similar positive effect might be assumed in multiple sclerosis (MS). Investigators compiled a systematic review focused on summarizing the possible effects of coffee and caffeine in MS.
Ocrelizumab Reduces Progression of Upper Extremity Impairment in Primary Progressive MS
January 8th 2019

Ocrelizumab Reduces Progression of Upper Extremity Impairment in Primary Progressive MS

Laura Joszt, MA
For patients with multiple sclerosis (MS), upper extremity (UE) impairment is not uncommon, and patients with primary progressive MS tend to have a higher prevalence of UE dysfunction and greater impairment.
Stem Cell Transplant Effective Therapy in Patients With RRMS
January 5th 2019

Stem Cell Transplant Effective Therapy in Patients With RRMS

Samantha DiGrande
A recent prospective phase 2 study sought to investigate autologous hematopoietic stem cell transplantation as a therapeutic intervention in multiple sclerosis (MS).
Perceptions of Patients With MS and Caregivers on Daily Activity Performance
January 3rd 2019

Perceptions of Patients With MS and Caregivers on Daily Activity Performance

Laura Joszt, MA
An evaluation of cognitive function measurements, performance in daily activities, and the perception of cognitive functions in patients with multiple sclerosis (MS) found caregiver perceptions more closely correlate with the test measurements than patient perceptions.
Genetic Risk Variant Tied to Type of CNS Cell Increases Risk of MS, Study Says
December 29th 2018

Genetic Risk Variant Tied to Type of CNS Cell Increases Risk of MS, Study Says

David Bai, PharmD
A genetic risk variant, rs7665090G, located near NFKB1, on astrocytes enhances the accessibility of the central nervous system (CNS) to peripheral immune cells, escalating the risk of autoimmune inflammation and multiple sclerosis (MS), according to the results of a recent study.
Switching Patients With MS Who Are Stable on Interferon β Has Suboptimal Outcomes
December 29th 2018

Switching Patients With MS Who Are Stable on Interferon β Has Suboptimal Outcomes

AJMC Staff
Patients with multiple sclerosis (MS) who are stable on an interferon β (INFβ) should remain on that therapy rather than switching to another INFβ, according to a study in ClinicoEconomics and Outcomes Research.
Researchers Identify New, Overlooked Target to Treat Multiple Sclerosis
December 27th 2018

Researchers Identify New, Overlooked Target to Treat Multiple Sclerosis

Laura Joszt, MA
Mature oligodendrocytes have been overlooked in the past as a way to treat multiple sclerosis, but a new study has found they might be able to help with remyelinating axons the same as new oligodendrocytes.
Food Allergies Associated With More Relapses in Patients With MS
December 21st 2018

Food Allergies Associated With More Relapses in Patients With MS

Laura Joszt, MA
Patients with multiple sclerosis (MS) who also have food allergies have more relapses than patients with no known food allergy, according to a new study published in the Journal of Neurology, Neurosurgery & Psychiatry.
FDA Warns of Rare Risks of MS Drug Alemtuzumab
December 20th 2018

FDA Warns of Rare Risks of MS Drug Alemtuzumab

Jaime Rosenberg
The FDA has issued a warning that rare but serious cases of stroke and tears in the lining of arteries in the head and neck have occurred in patients with multiple sclerosis (MS) who received treatment with alemtuzumab (Lemtrada).
CDC Launching Surveillance System to Study Multiple Sclerosis, Other Neurological Conditions
December 14th 2018

CDC Launching Surveillance System to Study Multiple Sclerosis, Other Neurological Conditions

Jaime Rosenberg
With $5 million appropriated from Congress, CDC is launching a National Neurological Conditions and Surveillance System to help increase understanding of neurological disorders and to further support neurologic research, starting with multiple sclerosis and Parkinson disease.
Some Lifestyle Factors Positively Impact Depression in People With Multiple Sclerosis
December 9th 2018

Some Lifestyle Factors Positively Impact Depression in People With Multiple Sclerosis

Laura Joszt, MA
Lifestyle factors like exercise, meditation, and alcohol use were inversely associated with depression risk, while smoking significantly predicted depression.
International Consensus on Timely Care for Multiple Sclerosis
December 7th 2018

International Consensus on Timely Care for Multiple Sclerosis

David Bai, PharmD
Multiple sclerosis (MS) is a progressive neurological disease that requires timely management, and a panel of neurologists has developed an internationally applicable standard of care for timely management in patients with MS.
Patients Who Stop Taking Gilenya May Experience Worsening of Multiple Sclerosis
December 4th 2018

Patients Who Stop Taking Gilenya May Experience Worsening of Multiple Sclerosis

Laura Joszt, MA
The FDA has issued a safety warning that patients who stopped taking Gilenya experienced worsening of multiple sclerosis, compared with before treatment started or during treatment, in rare cases.
Analysis Finds Rising Pregnancy Rates Among Women With Multiple Sclerosis
October 11th 2018

Analysis Finds Rising Pregnancy Rates Among Women With Multiple Sclerosis

David Bai, PharmD
A retrospective study by Houtchens et al on annual pregnancy rates from 2006 to 2014 reveals that US women with multiple sclerosis (MS) had increased pregnancy rates as compared to women without MS.
Top 5 AJMC® Articles of September 2018
September 30th 2018

Top 5 AJMC® Articles of September 2018

Here are the top 5 articles for the month of September.
Sex Hormones May Play an Important Role in Multiple Sclerosis Prevalence and Development
September 29th 2018

Sex Hormones May Play an Important Role in Multiple Sclerosis Prevalence and Development

David Bai, PharmD
In a review of sex hormones and their role in the development of multiple sclerosis (MS), Ysrraelit and Correale compiled multiple references to provide clinical details regarding hormones and their respective immunological mechanisms.
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