Migraine

The AJMC® Migraine compendium is a comprehensive resource for clinical news and expert insights for the recurring type of headache, which is accompanied by side effects.

Latest News

AJMC
Coverage With Evidence Development Study Shows Benefits in Patients With Migraine Treated With Remote Electrical Neuromodulation

April 8th 2025

A coverage with evidence development (CED) study demonstrated significant and clinically meaningful benefits in patients with migraine treated with remote electrical neuromodulation (REN). Health plans should support clinicians’ REN prescriptions by ensuring adequate coverage.

Migraine vice | Image Credit: © Andrii Zastrozhnov-stock.adobe.com
Optimizing Episodic Migraine Care: ACP’s Latest Treatment Guidance

February 3rd 2025

Prior Authorization Requirements for Calcitonin Gene-Related Peptide Antagonists

April 20th 2023

Image of a hurting perosn
Care for Migraine Insufficient in Germany, Online Survey Finds

March 25th 2022

woman with migraine
Comparing Benign Recurrent Vertigo With Vestibular Migraine, Menière's Disease

March 21st 2022

More News

Epigenetic Diet for Migraine Requires More Research, Review Finds
December 9th 2019

Epigenetic Diet for Migraine Requires More Research, Review Finds

Alison Rodriguez
The epigenetic diet is often recommended for patient with migraine; however, the diet does not necessarily affect the epigenetic profile, suggesting the need for more research investigating the combined effect of folate and valproic acid in migraine in order to determine dietary recommendations.
Acupuncture for Migraine May Have Some Benefits but Quality of Studies Lacking, Report Says
December 5th 2019

Acupuncture for Migraine May Have Some Benefits but Quality of Studies Lacking, Report Says

Gianna Melillo
The studies did not disclose whether acupuncture was utilized to ease acute attacks or the overall condition, calling into question the significance of collected data.
Aspirin Effective in Treating Acute Migraine, Preventing Recurrent Migraine, Review Finds
December 4th 2019

Aspirin Effective in Treating Acute Migraine, Preventing Recurrent Migraine, Review Finds

Matthew Gavidia
Aspirin, in high doses from 900 to 1300 mg, was shown to be an effective and safe treatment option for acute migraine headaches, with further research showing its potential efficacy in preventing recurrent migraine headaches through lower doses of 81 to 325 mg, according to findings of a review.
Case Study Indicates Link Between Stroke and Migraine
November 30th 2019

Case Study Indicates Link Between Stroke and Migraine

Alison Rodriguez
A recent case study of a patient with a history of migraine with visual aura revealed a pathophysiological link between stroke and migraine, demonstrating the need for additional research that links migrainous infarction (MI) and stroke-related migraine.
Cannabis Reduces Headache, Migraine Severity by Nearly Half, Study Shows
November 27th 2019

Cannabis Reduces Headache, Migraine Severity by Nearly Half, Study Shows

Matthew Gavidia
Inhaled cannabis was shown to reduce self-reported headache and migraine severity by nearly 50%, according to study findings.
Researchers Uncover Mechanism Behind Relationship of Migraine, Opioid-Induced Pain in Mice
November 22nd 2019

Researchers Uncover Mechanism Behind Relationship of Migraine, Opioid-Induced Pain in Mice

Matthew Gavidia
The link between prolonged opioid treatment and an increased frequency, severity of migraines has been attributed to the discovery of a peptide confirmed in mice that distinguishes the relationship of migraine pain and opioid-induced hyperalgesia (OIH), according to study findings.
Longitudinal Assessment Reveals Cost-Effectiveness of Erenumab for Treatment of Migraine
November 17th 2019

Longitudinal Assessment Reveals Cost-Effectiveness of Erenumab for Treatment of Migraine

Matthew Gavidia
A longitudinal assessment of the cost-effectiveness of erenumab as a treatment for migraine exhibited higher patient utility when compared with placebo, according to study findings published this week.
Migraine Attack in Response to Nitroglycerin Showed Greater Cardiovascular Responses, Study Finds
November 16th 2019

Migraine Attack in Response to Nitroglycerin Showed Greater Cardiovascular Responses, Study Finds

Alison Rodriguez
A study investigating the cardiovascular responses to nitroglycerin in migraine found that migraineurs who developed a migraine-like attack in response to nitroglycerin demonstrated greater systemic cardiovascular responses compared with non-headache controls.
Study Results Suggest Long-Term Safety of Erenumab for Treating Migraine
November 9th 2019

Study Results Suggest Long-Term Safety of Erenumab for Treating Migraine

Alison Rodriguez
An interim analysis of migraine drug erenumab showed that it continued to be safe and well-tolerated, with an adverse event profile consistent with those found in shorter-term placebo-controlled studies.
AJMC® in the Press, November 8, 2019
November 8th 2019

AJMC® in the Press, November 8, 2019

AJMC Staff
Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.
Higher Dosage of Erenumab Shows Improved Efficacy for Preventive Migraine Treatment
November 5th 2019

Higher Dosage of Erenumab Shows Improved Efficacy for Preventive Migraine Treatment

Matthew Gavidia
Patients with prior preventive treatment failures for migraine were shown to benefit more from a higher dose of erenumab (140 mg) versus a lower dose (70 mg), according to study findings.
Intranasal Lidocaine May Be Effective Acute Migraine Treatment, Study Finds
November 2nd 2019

Intranasal Lidocaine May Be Effective Acute Migraine Treatment, Study Finds

Alison Rodriguez
Intranasal lidocaine may be a useful option for patients with an acute migraine, according to a study which showed the drug had a high success rate, low pain intensity, infrequent need for rescue medicine, and tolerable adverse events.
Evaluating Migraine Advancements Through a Payer's Perspective
November 1st 2019

Evaluating Migraine Advancements Through a Payer's Perspective

Matthew Gavidia
Panelists YuQian Liu, PharmD, and Carly Rodriguez, PharmD, FAMCP, discussed migraine treatment advances, available real-world evidence, and migraine management strategies with moderator Charles Collins, MS, MBA, at AMCP Nexus 2019 in National Harbor, Maryland.
Study Suggests Healthcare Students May Be Uninformed About Migraine Treatments
October 26th 2019

Study Suggests Healthcare Students May Be Uninformed About Migraine Treatments

Alison Rodriguez
A new study says most healthcare students are uninformed about migraine treatments and may not be prepared to advise patients.
Fremanezumab Shown to Improve Headache-Related Disability Outcomes in Patients With Chronic and Episodic Migraines
October 22nd 2019

Fremanezumab Shown to Improve Headache-Related Disability Outcomes in Patients With Chronic and Episodic Migraines

Matthew Gavidia
Fremanezumab was shown to clinically improve headache-related disability outcomes in patients with either chronic or episodic migraines and reported inadequate response to 2 to 4 classes of migraine preventative medications, according to a study presented at the 144th Annual Meeting of the American Neurological Association.
Population-Based Study Identifies Numerous Risk Factors for Migraine
October 19th 2019

Population-Based Study Identifies Numerous Risk Factors for Migraine

AJMC Staff
A recent study presented at the American Neurological Association meeting identified vascular and nonvascular risk factors associated with migraine in a population-based study in an effort to help identify targets for reducing migraine-related disability.
Noninvasive Treatment Exhibits Potential Effectiveness for Patients With Vestibular Migraine Attacks
October 15th 2019

Noninvasive Treatment Exhibits Potential Effectiveness for Patients With Vestibular Migraine Attacks

Matthew Gavidia
Noninvasive nerve stimulation shows potential effectiveness as a novel treatment for vestibular migraine attacks, according to a small, preliminary study.
Noninvasive Treatment Exhibits Potential Effectiveness for Patients With Vestibular Migraine Attacks
October 15th 2019

Noninvasive Treatment Exhibits Potential Effectiveness for Patients With Vestibular Migraine Attacks

Matthew Gavidia
Noninvasive nerve stimulation shows potential effectiveness as a novel treatment for vestibular migraine attacks, according to a small, preliminary study.
Patients Who Have Aura With Migraine Have Smaller Brain Structures Than Healthy Subjects
October 11th 2019

Patients Who Have Aura With Migraine Have Smaller Brain Structures Than Healthy Subjects

AJMC Staff
A recent study sought to identify possible differences in subcortical structures between patients who have migraine with aura (MwA) and healthy subjects, and also to determine the correlations between the characteristics of migraine aura and the volumes of subcortical structures.
Contemporary Management of Migraine: An Interview With Jessica Ailani, MD
October 7th 2019

Contemporary Management of Migraine: An Interview With Jessica Ailani, MD

Current and Emerging Therapies for the Treatment and Prevention of Migraine: An Interview With Stephen D. Silberstein, MD
October 4th 2019

Current and Emerging Therapies for the Treatment and Prevention of Migraine: An Interview With Stephen D. Silberstein, MD

Elevated C-Reactive Protein Levels Linked With Migraines Occurring 15 Days or More, or With Aura
October 2nd 2019

Elevated C-Reactive Protein Levels Linked With Migraines Occurring 15 Days or More, or With Aura

Allison Inserro
Researchers said the previous results on high sensitivity C-reactive protein and migraine are mixed, and the relationship to insomnia limited; the aim of this study was to evaluate the cross-sectional association between hs-CRP and types of headache, and to see whether the relationship to insomnia could be reproduced.
IgG Elimination Diet Plus Probiotics May Be Beneficial for Patients With Both Migraine and IBS
September 28th 2019

IgG Elimination Diet Plus Probiotics May Be Beneficial for Patients With Both Migraine and IBS

Alison Rodriguez
An immunoglobulin G (IgG) elimination diet combined with probiotics may be effective and beneficial for patients with both migraine and irritable bowel syndrome (IBS), according to a recent study,
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September 27th 2019

Study Summary: Migraine Prophylaxis and Risk of Cardiovascular Events, Cerebrovascular Events, and Mortality

Hoffman V, Xue F, Ezzy SM, et al. Risk of cardiovascular cerebrovascular events and mortality in patients with migraine receiving prophylactic treatments: an observational cohort study [published online June 13, 2019]. Cephalalgia. 2019. doi: 10.1177/0333102419856630.
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September 27th 2019

Study Summary: The Effects of Headache-Free Days on Quality of Life, Work, and Healthcare Use Among Patients With Migraine

Doane MJ, Gupta S, Vo P, Laflamme AK, Fang J. Associations between headache-free days patient-reported outcomes among migraine patients: a cross-sectional analysis of survey data in Europe [published online July 26, 2019]. Pain Ther. 2019. doi: 10.1007/s40122-019-0133-1.
Study Looks at Links Between Perceptions of Disability, Job Satisfaction in Patients With Migraine
September 24th 2019

Study Looks at Links Between Perceptions of Disability, Job Satisfaction in Patients With Migraine

AJMC Staff
A recent study indicates that the level of job satisfaction among patients with migraine influences the impact of perceived disability on work productivity.
Researchers Suggest Stepwise Approach for Managing Childhood Headache
September 21st 2019

Researchers Suggest Stepwise Approach for Managing Childhood Headache

Alison Rodriguez
A recent literature review suggests a new clinical pathway for children presenting with headache in the emergency department.
Dr Abraham Nagy Highlights the Need to Educate on the Impact Headaches Can Have
September 20th 2019

Dr Abraham Nagy Highlights the Need to Educate on the Impact Headaches Can Have

Migraines and cluster headaches can have devastating consequences on people’s lives, and there is a need to educate the public about the impact these disorders can have, said Abraham Nagy, MD, chair of neurology at University of Las Vegas and director of Nevada Headache Institute.
Study Looks at Connection Between Cerebellum Changes, Pain in Migraine
September 14th 2019

Study Looks at Connection Between Cerebellum Changes, Pain in Migraine

Alison Rodriguez
A recent study looked at the role of the cerebellum and brainstem in migraine pain.
Migraines Linked to Future Dementia, Alzheimer, but Only in Women
September 11th 2019

Migraines Linked to Future Dementia, Alzheimer, but Only in Women

Allison Inserro
Finding a midlife risk factor for dementia—such as migraine—could allow for earlier detection of at‐risk patients.
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