Migraine

The AJMC® Migraine compendium is a comprehensive resource for clinical news and expert insights for the recurring type of headache, which is accompanied by side effects.

Latest News

AJMC
Coverage With Evidence Development Study Shows Benefits in Patients With Migraine Treated With Remote Electrical Neuromodulation

April 8th 2025

A coverage with evidence development (CED) study demonstrated significant and clinically meaningful benefits in patients with migraine treated with remote electrical neuromodulation (REN). Health plans should support clinicians’ REN prescriptions by ensuring adequate coverage.

Migraine vice | Image Credit: © Andrii Zastrozhnov-stock.adobe.com
Optimizing Episodic Migraine Care: ACP’s Latest Treatment Guidance

February 3rd 2025

Prior Authorization Requirements for Calcitonin Gene-Related Peptide Antagonists

April 20th 2023

Image of a hurting perosn
Care for Migraine Insufficient in Germany, Online Survey Finds

March 25th 2022

woman with migraine
Comparing Benign Recurrent Vertigo With Vestibular Migraine, Menière's Disease

March 21st 2022

More News

Study Links Smartphone Use to Greater Need for Medication Among People With Headache
March 27th 2020

Study Links Smartphone Use to Greater Need for Medication Among People With Headache

Alison Rodriguez
Using a smartphone was associated with higher usage of acute medication, but less relief, in individuals with new-onset headache or increased severity of headache.
Study Suggests Tension Headaches Overdiagnosed in the Emergency Department
March 22nd 2020

Study Suggests Tension Headaches Overdiagnosed in the Emergency Department

Alison Rodriguez
Patients were reclassified as having other types of headaches.
MRIs Find Abnormalities in Central Vestibular Cortex of Some Patients With Migraine
March 17th 2020

MRIs Find Abnormalities in Central Vestibular Cortex of Some Patients With Migraine

Gianna Melillo
Magnetic resonance imaging (MRI) scans of patients with vestibular migraine reveal abnormalities in the central vestibular cortex, according to a study published in Brain and Behavior.
Family History of Migraine Linked to Earlier Age of Onset, Study Says
March 15th 2020

Family History of Migraine Linked to Earlier Age of Onset, Study Says

Alison Rodriguez
Family history with migraine affect male and female patients differently, according to a recent study.
Report Finds Natural Clusters of Chronic Migraine Phenotypes
March 10th 2020

Report Finds Natural Clusters of Chronic Migraine Phenotypes

Gianna Melillo
Researchers were able to use questionnaire responses to accurately determine natural clusters of chronic migraine phenotypes, according to a study published in Scientific Reports.
Review Assesses Role of Vitamin D in Migraine Mechanism, Treatment
March 7th 2020

Review Assesses Role of Vitamin D in Migraine Mechanism, Treatment

Gianna Melillo
Eighteen out of 30 studies included in a recent literature review, published in Nutrients, showed a link between serum vitamin D levels and headaches, with the strongest connection established between serum vitamin D and migraine.
Chocolate Lover? Review Finds No Definitive Proof It Triggers Your Migraines
March 5th 2020

Chocolate Lover? Review Finds No Definitive Proof It Triggers Your Migraines

Gianna Melillo
Although it is the most commonly cited food-based trigger for migraines, there is insufficient evidence to prove chocolate is a migraine trigger, according to a review of 25 studies published in Nutrients.
ICER Releases Final Evidence Report on Acute Treatments for Migraine
February 27th 2020

ICER Releases Final Evidence Report on Acute Treatments for Migraine

Gianna Melillo
The Institute for Clinical and Economic Review (ICER) released its final evidence report on acute treatments of migraine on February 25. The Institute’s last report on migraine treatment was released in 2018.
Review Outlines Relationship Between Gut-Brain Axis, Migraine
February 25th 2020

Review Outlines Relationship Between Gut-Brain Axis, Migraine

Gianna Melillo
The association between migraine and several gastrointestinal (GI) disorders prompted investigations into the bidirectional relationship between the GI system and central nervous system. Researchers call this association the “gut-brain axis,” and they evaluated direct and indirect evidence linking migraines to the axis in a recent review published in The Journal of Headache and Pain.
Study Suggests 5 Stroke Risk Factors for Those With Migraine, Aura
February 22nd 2020

Study Suggests 5 Stroke Risk Factors for Those With Migraine, Aura

Alison Rodriguez
The research revealed 5 risk factors for stroke for patients with migraine with aura.
Migraineurs Exhibit Unique Sensory Responses to Stimuli
February 19th 2020

Migraineurs Exhibit Unique Sensory Responses to Stimuli

Gianna Melillo
Researchers determined that migraineurs exhibit unique responses to tactile stimuli compared with controls, according to a study published in Cephalalgia.
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February 18th 2020

Concomitant Medical Conditions and Total Cost of Care in Patients With Migraine: A Real-World Claims Analysis

Michael Polson, PharmD, MS Ted D. Williams, PharmD, BCPS Lindsay C. Speicher, JD Mkaya Mwamburi, MD, PhD, MA Peter S. Staats, MD, MBA Andrew T. Tenaglia, BA
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February 18th 2020

Real-World Assessment of Concomitant Opioid Utilization and Associated Trends in Patients With Migraine

Anne Kangethe, PharmD, PhD, RPh, MPH Michael Polson, PharmD, MS Themmi M. Evangelatos, PharmD, MSBA Lindsay C. Speicher, JD Andrew T. Tenaglia, BA Peter S. Staats, MD, MBA Eric J. Liebler Mkaya Mwamburi, MD, PhD, MA
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February 18th 2020

Patient Experience With Non-Invasive Vagus Nerve Stimulator: gammaCore Patient Registry

Mkaya Mwamburi, MD, PhD, MA Eric J. Liebler Peter S. Staats, MD, MBA
Evidence Links Migraine and Visual Cortex Abnormalities
February 12th 2020

Evidence Links Migraine and Visual Cortex Abnormalities

Gianna Melillo
Those who suffer from migraines have a hyperexcitable visual cortex, according to a study published in Neuroimage: Clinical. This is the first reported evidence establishing a link between migraine experiences and abnormalities in the visual cortex.
Researchers Outline Lessons Learned About Chronic Migraine Gleaned From Neuroimaging
February 9th 2020

Researchers Outline Lessons Learned About Chronic Migraine Gleaned From Neuroimaging

Alison Rodriguez
Where do migraines begin in the brain and what has neuroimaging identified so far about how the disease alters pain processes and functioning? A recent article reviewed what is known so far.
Migraineurs Exhibit Comorbidities Spanning ICD-10 Spectrum
February 4th 2020

Migraineurs Exhibit Comorbidities Spanning ICD-10 Spectrum

Gianna Melillo
Electronic medical record data showed migraine is associated with a systematic increase in morbidity across the spectrum of the International Classification of Diseases, Tenth Revision (ICD-10), according to a recently published study in The Journal of Headache and Pain.
Reduction of Prolactin Associated With Pain Relief, Headache Study Finds
February 1st 2020

Reduction of Prolactin Associated With Pain Relief, Headache Study Finds

Alison Rodriguez
Migraine was the most common type of headache in patients with hyperprolactinemia.
Chronic Pain in Migraine May Be Mitigated by Craniosacral Therapy
January 25th 2020

Chronic Pain in Migraine May Be Mitigated by Craniosacral Therapy

Sara Karlovitch
The literature review examined randomized controlled trials for craniosacral therapy (CST) in patients with migraine and other conditions that cause pain.
Use of ICHD-3 Increases Specificity When Diagnosing Migraine With Aura and Typical Aura
January 22nd 2020

Use of ICHD-3 Increases Specificity When Diagnosing Migraine With Aura and Typical Aura

Gianna Melillo
Researchers determined that new diagnostic criteria in the International Classification of Headache Disorders, 3rd edition (ICHD-3) are significantly more specific than that included in ICHD-3 beta when it comes to diagnosing migraine with aura and with typical aura, according to a study published in The Journal of Headache and Pain.
Evidence Shows Genetic, Epigenetic Factors May Be Responsible for Migraine Transformation
January 18th 2020

Evidence Shows Genetic, Epigenetic Factors May Be Responsible for Migraine Transformation

Sara Karlovitch
Individuals’ susceptibility to genetic and epigenetic factors may be responsible for the transformation of episodic migraine to chronic migraine in some patients, according to a new review published in The Journal of Headache and Pain.
Data Reveal Predictors of Transformation From Episodic to Chronic Migraine
January 15th 2020

Data Reveal Predictors of Transformation From Episodic to Chronic Migraine

Gianna Melillo
A systematic review and meta-analysis of data collected from observational cohort studies reveals several clinical and sociodemographic factors are predictors of chronic migraine.
Current Stimulation to Occipital Cortex Effective in Treating Episodic Migraine
January 7th 2020

Current Stimulation to Occipital Cortex Effective in Treating Episodic Migraine

Gianna Melillo
In a study published December 26 in the Journal of Clinical Medicine, researchers tested the effects of cathodal transcranial direct current stimulation in the occipital cortex of 42 patients with episodic migraine.
AJMC® in the Press, January 3, 2020
January 3rd 2020

AJMC® in the Press, January 3, 2020

AJMC Staff
Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.
Italian Study Finds Cost of Migraine Treatment Higher for Women, Elderly
January 2nd 2020

Italian Study Finds Cost of Migraine Treatment Higher for Women, Elderly

Gianna Melillo
In a recently published study in The Journal of Headache and Pain, Italian researchers compiled data on 548 patients suffering from chronic and episodic migraines enrolled in a tertiary level headache center to determine overall costs incurred.
Review Finds Studies on Migraine and Caffeine Association Inconclusive
December 27th 2019

Review Finds Studies on Migraine and Caffeine Association Inconclusive

Gianna Melillo
In a narrative review published in Frontiers in Neurology, researchers compiled evidence from various studies on the relationship between caffeine and migraines. From the data collected, researchers concluded that the relationship between them remains vague.
Greek Researchers Outline New Consensus on Diagnosis and Treatment of Migraine
December 19th 2019

Greek Researchers Outline New Consensus on Diagnosis and Treatment of Migraine

Gianna Melillo
On behalf of the Hellenic Headache Society, a group of Greek researchers reported a consensus on the diagnosis and treatment of adult migraines in The Journal of Headache and Pain on December 13.
Low Sleep Efficiency Associated With Higher Odds of Migraine, Study Shows
December 18th 2019

Low Sleep Efficiency Associated With Higher Odds of Migraine, Study Shows

Matthew Gavidia
Sleep fragmentation, which is defined by low sleep efficiency, was linked with higher odds of migraine onset on day 1, according to study findings published this week.
Study Finds Bidirectional Relationship Between Asthma, Migraines
December 13th 2019

Study Finds Bidirectional Relationship Between Asthma, Migraines

Gianna Melillo
Migraines increase the risk of asthma, and asthma is also associated with an elevated risk of migraine, according to new research.
Researchers Uncover Effectiveness of 2 Preventive Agents in Reducing Incidence, Severity of Pediatric Migraine
December 11th 2019

Researchers Uncover Effectiveness of 2 Preventive Agents in Reducing Incidence, Severity of Pediatric Migraine

Matthew Gavidia
Two migraine prevention agents, cinnarizine and sodium valproate, were shown to be safe and effective in reducing incidence and severity of migraine within children and adolescents, according to study findings. Safety findings must be weighed alongside warnings from European regulators about the risks of valproate for girls and adolescent women who could bear children in the future.
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