Migraine

The AJMC^® Migraine compendium is a comprehensive resource for clinical news and expert insights for the recurring type of headache, which is accompanied by side effects.

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Coverage With Evidence Development Study Shows Benefits in Patients With Migraine Treated With Remote Electrical Neuromodulation

By Andrea Synowiec, DO
Alit Stark-Inbar, PhD

April 8th 2025

A coverage with evidence development (CED) study demonstrated significant and clinically meaningful benefits in patients with migraine treated with remote electrical neuromodulation (REN). Health plans should support clinicians’ REN prescriptions by ensuring adequate coverage.

Migraine vice | Image Credit: © Andrii Zastrozhnov-stock.adobe.com

Optimizing Episodic Migraine Care: ACP’s Latest Treatment Guidance

By Maggie L. Shaw

February 3rd 2025

Prior Authorization Requirements for Calcitonin Gene-Related Peptide Antagonists

By Lindsay Musial, PharmD
Steven Kheloussi, PharmD, MBA

April 20th 2023

Image of a hurting perosn

Care for Migraine Insufficient in Germany, Online Survey Finds

By Maggie L. Shaw

March 25th 2022

woman with migraine

Comparing Benign Recurrent Vertigo With Vestibular Migraine, Menière's Disease

By Gianna Melillo

March 21st 2022

More News

Dr Messoud Ashina Talks Through the 5-Year Safety and Efficacy Data on Erenumab

October 19th 2020

Dr Messoud Ashina Talks Through the 5-Year Safety and Efficacy Data on Erenumab

Data from a 5-year open-label treatment period on the safety profile of erenumab (Aimovig) showed the treatment helped patients with episodic migraine achieve a sustained reduction in the number of monthly migraine days and the number of days in which therapies were needed for acute migraines.

Study Describes Relationship Between Migraine, Postoperative Nausea and Vomiting

October 14th 2020

Study Describes Relationship Between Migraine, Postoperative Nausea and Vomiting

Migraine is a significant risk factor for postoperative nausea and vomiting, according to results of a retrospective study published in the Journal of Clinical Medicine.

Dr Rigmor Jensen Discusses Prevalence of Medication Overuse Headache

October 13th 2020

Dr Rigmor Jensen Discusses Prevalence of Medication Overuse Headache

Medication overuse headache is a huge problem in societies that don't have access to proper headache care as patients take more over-the-counter, readily available treatments, said Rigmor Jensen, MD, professor of neurology at The University of Copenhagen and director of the Danish Headache Center.

Smartphone App Unable to Accurately Predict Episodic Migraine

October 7th 2020

Smartphone App Unable to Accurately Predict Episodic Migraine

In an attempt to develop a multivariable predictive model for days with new-onset migraine headaches, researchers found episodic migraine attacks were not predictable based on self-prediction or on self-reported exposure to common trigger factors.

Report Details Need for Treatment Guidelines on Comorbid Migraine, Major Depressive Disorder

October 6th 2020

Report Details Need for Treatment Guidelines on Comorbid Migraine, Major Depressive Disorder

Treatment guidelines for comorbid depression and migraine are warranted to ensure optimal efficacy and avoid possible pitfalls in psychopharmacotherapy, according to study results.

Study Finds GONB With Bupivacaine Inferior to IV Metoclopramide as First-line Treatment for Migraine

September 30th 2020

Study Finds GONB With Bupivacaine Inferior to IV Metoclopramide as First-line Treatment for Migraine

According to a study published in Headache, greater occipital nerve blocks (GONB) with bupivacaine were not as effective as intravenous (IV) metoclopramide as a first-line treatment for migraineurs who presented to emergency departments.

Study Examines Relationship Between Sexual Orientation, Migraine Prevalence

September 28th 2020

Study Examines Relationship Between Sexual Orientation, Migraine Prevalence

New research published in JAMA Neurology highlights disparities in migraine based on sexual orientation in the United States.

Survey Results Underscore Migraine’s Impact on Family Planning

September 24th 2020

Survey Results Underscore Migraine’s Impact on Family Planning

Many women suffering from migraine say the condition affects family planning, while this finding is more prevalent among women who are younger and experience menstrual and chronic migraine.

Review Highlights Prevalence of Restless Legs Syndrome Among Migraineurs

September 22nd 2020

Review Highlights Prevalence of Restless Legs Syndrome Among Migraineurs

Prevalence of restless legs syndrome is elevated among individuals with migraine according to a systematic review and meta-analysis published in Pain Research and Management.

Green Light Exposure Therapy May Reduce Migraine Frequency

September 17th 2020

Green Light Exposure Therapy May Reduce Migraine Frequency

In individuals suffering from chronic and episodic migraine, a preliminary study shows exposure to green light therapy significantly reduced headache days and improved both intensity and duration of headache attacks.

Review Outlines Relationship Between Magnesium Deficiency, Migraine

September 16th 2020

Review Outlines Relationship Between Magnesium Deficiency, Migraine

A systematic review concluded that a correlation between magnesium deficiency and headaches exists, while magnesium deficiency may be an independent risk factor for migraine.

Comparing Psychological Difficulties Among Migraineurs and Patients With Epilepsy

September 10th 2020

Comparing Psychological Difficulties Among Migraineurs and Patients With Epilepsy

Compared with patients with epilepsy, migraineurs tend to suffer more from psychological difficulties, according to a study published in Journal of Multidisciplinary Healthcare.

Erenumab Aids Transition From Chronic to Episodic Migraine

September 6th 2020

Erenumab Aids Transition From Chronic to Episodic Migraine

A study using real-world data from an Italian region found two-thirds of patients with chronic migraine treated with erenumab transitioned to episodic migraine within 6 months.

Machine Learning May Facilitate Headache Disorder Diagnoses

September 2nd 2020

Machine Learning May Facilitate Headache Disorder Diagnoses

Using data-driven machine learning approaches, researchers analyzed patient-reported symptoms of migraine and demonstrated automated classification of headache disorders.

Study Analyzes Effects of Erenumab Based on MMD Reduction Threshold

August 31st 2020

Study Analyzes Effects of Erenumab Based on MMD Reduction Threshold

Using data from the Study to Evaluate the Efficacy and Safety of Erenumab in Migraine Prevention, researchers were able to analyze the efficacy of erenumab at ≥50%, ≥75%, and 100% thresholds for reduction in monthly migraine days.

Young Women With Migraine Have More Sleep Issues, Study Says

August 27th 2020

Young Women With Migraine Have More Sleep Issues, Study Says

In young college-age women, migraine was associated with several sleep issues, although no differences in sleep quality were reported between migraineurs and controls, according to a recent study.

Brain imaging

August 24th 2020

Study Finds Women Migraineurs With Aura Do Not Exhibit Altered Thalamic Volume

The pathophysiology of migraine with aura in women does not involve alteration of thalamic volume, according to a study published in NeuroImage: Clinical.

Does Obesity Impact Migraine Prevalence?

August 18th 2020

Does Obesity Impact Migraine Prevalence?

In individuals under the age of 50, both total body obesity and abdominal obesity were associated with greater migraine prevalence and attack frequency, according to a study published in The Journal of Headache and Pain.

How Do Headache-Free Days Impact Migraine-Related Disability?

August 17th 2020

How Do Headache-Free Days Impact Migraine-Related Disability?

A higher number of headache-free days (HFDs) is associated with decreased headache-related disability among individuals with migraine, according to a study published in the Journal of Managed Care & Specialty Pharmacy.

Study Finds Erenumab Safe, Effective in Treating Menstrual Migraine

August 10th 2020

Study Finds Erenumab Safe, Effective in Treating Menstrual Migraine

Data from women with menstrual migraine enrolled in the Study to Evaluate the Efficacy and Safety of Erenumab in Migraine Prevention show erenumab is a safe and effective option for treating the condition

$Real-Word Evidence Outlines Efficacy of Erenumab for Highly Therapy-Refractory Migraine$

August 5th 2020

Real-Word Evidence Outlines Efficacy of Erenumab for Highly Therapy-Refractory Migraine

A study based on real-world data collected from the West German Headache Center at the University Hospital Essen, Germany, concluded erenumab appears to be a promising treatment option for patients with highly therapy-refractory migraine.

Chronic Migraine Linked With Disruption of Normal White Matter Integrity, Study Finds

August 3rd 2020

Chronic Migraine Linked With Disruption of Normal White Matter Integrity, Study Finds

Chronic migraine (CM) may be associated with widespread disruption of normal white matter (WM) integrity in the brain, according to a study published in The Journal of Headache and Pain.

Erenumab Autoinjector Well Received by Patients, Study Finds

July 28th 2020

Erenumab Autoinjector Well Received by Patients, Study Finds

When it comes to ease of use, ability to self-inject, and confidence in using an erenumab-prefilled disposable autoinjector, individuals with migraine consistently endorsed the preventive treatment, according to study results published in Patient Preference and Adherence.

Data Highlight Long-Term Efficacy of Erenumab for Episodic Migraine

July 28th 2020

Data Highlight Long-Term Efficacy of Erenumab for Episodic Migraine

In patients with episodic migraine, erenumab provided sustained efficacy for the condition over the course of 1 year, according to new results from a study to evaluate the efficacy and safety of erenumab in migraine prevention (STRIVE), published in Neurology.

Review Explores Association Between Chronic Migraine, Suicide Ideation

July 23rd 2020

Review Explores Association Between Chronic Migraine, Suicide Ideation

Current existing research highlights the important association between the increased risk of suicidal behaviors among chronic migraineurs with and without aura, in both the clinical and general population worldwide, according to a systematic review published in Frontiers in Neurology.

Meta-Analysis Outlines Interrelationship of Migraine, Blood Pressure

July 22nd 2020

Meta-Analysis Outlines Interrelationship of Migraine, Blood Pressure

Positive genetic correlations of migraine with diastolic blood pressure (BP) and systolic BP exist, supporting the notions that diastolic BP plays a critical role in migraine susceptibility and BP and migraine share underlying biological mechanisms, according to a study published in Nature Communications.

Can Adulthood Attachment Mediate the Effects of Childhood Trauma on Migraine?

July 16th 2020

Can Adulthood Attachment Mediate the Effects of Childhood Trauma on Migraine?

The direct effect of childhood trauma on migraine is outweighed by the mediation effect of adulthood attachment, according to a study published in the International Journal of Environmental Research and Public Health.

Can Machine Learning Predict Medication Overuse in Migraineurs?

July 15th 2020

Can Machine Learning Predict Medication Overuse in Migraineurs?

A combination of machine learning and random optimization may aid in predicting medication overuse in migraineurs, if clinical/biochemical features, drug exposure, and lifestyle are taken into consideration, according to a study published in Computational and Structural Biotechnology Journal.

How Does Quarantine Impact Migraineurs?

July 7th 2020

How Does Quarantine Impact Migraineurs?

A survey conducted among migraineurs in Genova, Italy, found that during the coronavirus disease 2019 (COVID-19) quarantine, patients experienced fewer migraine attacks and less pain but exhibited moderate levels of depression correlated to migraine burden.

Experts Push for Limiting Co-pays, Increasing Migraine Medication Access During Pandemic

July 5th 2020

Experts Push for Limiting Co-pays, Increasing Migraine Medication Access During Pandemic

A recent article in the Journal of Head and Face Pain outlines strategies for migraine treatment without face-to-face visits, and describes ways health insurance companies can remove barriers to migraine care during the coronavirus disease 2019 (COVID-19) pandemic.

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