Migraine

The AJMC® Migraine compendium is a comprehensive resource for clinical news and expert insights for the recurring type of headache, which is accompanied by side effects.

Latest News

AJMC
Coverage With Evidence Development Study Shows Benefits in Patients With Migraine Treated With Remote Electrical Neuromodulation

April 8th 2025

A coverage with evidence development (CED) study demonstrated significant and clinically meaningful benefits in patients with migraine treated with remote electrical neuromodulation (REN). Health plans should support clinicians’ REN prescriptions by ensuring adequate coverage.

Migraine vice | Image Credit: © Andrii Zastrozhnov-stock.adobe.com
Optimizing Episodic Migraine Care: ACP’s Latest Treatment Guidance

February 3rd 2025

Prior Authorization Requirements for Calcitonin Gene-Related Peptide Antagonists

April 20th 2023

Image of a hurting perosn
Care for Migraine Insufficient in Germany, Online Survey Finds

March 25th 2022

woman with migraine
Comparing Benign Recurrent Vertigo With Vestibular Migraine, Menière's Disease

March 21st 2022

More News

Significant Migraine Burden Observed in Patients With at Least 4 Monthly Migraine Days and Prophylactic Treatment Failure
January 17th 2019

Significant Migraine Burden Observed in Patients With at Least 4 Monthly Migraine Days and Prophylactic Treatment Failure

David Bai, PharmD
Patients who have 4 or more migraine days per month and have failed on prophylactic treatment experience reduced quality of life, work productivity, and social activity involvement.
American Headache Society Includes CGRP Inhibitors in Updated Consensus Statement
January 15th 2019

American Headache Society Includes CGRP Inhibitors in Updated Consensus Statement

Jaime Rosenberg
Providing healthcare professionals with up-to-date guidance for the use of preventive and acute treatments for migraine, the American Headache Society has published a consensus statement outlining indications for initiating, continuing, combining, and switching the treatments.
AJMC® in the Press, January 11, 2019
January 11th 2019

AJMC® in the Press, January 11, 2019

AJMC Staff
Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.
Headache Disorders Associated With Risk of All-Cause Dementia
January 11th 2019

Headache Disorders Associated With Risk of All-Cause Dementia

Jaime Rosenberg
An analysis of 6 studies found an increased risk of all-cause dementia among patients with any headache. However, no association was found between headache and Alzheimer disease.
Prevalence of Atrial Septal Aneurysm in Patients With Migraine and Patent Foramen Ovale Associated With Ischemic Stroke
January 8th 2019

Prevalence of Atrial Septal Aneurysm in Patients With Migraine and Patent Foramen Ovale Associated With Ischemic Stroke

David Bai, PharmD
Patients with migraine, patent foramen ovale (PFO), and atrial septal aneurysm (ASA) have more frequent ischemic brain lesions, migraine with aura, and larger PFO sizes than patients with migraines and PFO without ASA, according to the results of a recent study.
Botox Superior to Placebo for Chronic Migraine, Meta-Analysis Finds
January 5th 2019

Botox Superior to Placebo for Chronic Migraine, Meta-Analysis Finds

Jaime Rosenberg
A meta-analysis of 17 studies finds that botulinum toxin (Botox) is superior to placebo for the prophylactic treatment of chronic migraine.
Migraine Prevalence May Be Associated With Spontaneous Coronary Artery Dissection
January 4th 2019

Migraine Prevalence May Be Associated With Spontaneous Coronary Artery Dissection

David Bai, PharmD
Patients with a history of migraine are more likely to develop spontaneous coronary artery dissection at a younger age, have depression, and post-SCAD chest pains compared with patients without a migraine history, according to the results of a recent study.
Sleep Disorders, Particularly Insomnia, Impact Migraine Prevalence
December 28th 2018

Sleep Disorders, Particularly Insomnia, Impact Migraine Prevalence

Jaime Rosenberg
Researchers have found that sleep disorders, especially insomnia, can impact the prevalence of migraine.
Red Wine Tops the List of Alcohols Most Reported as Migraine Trigger
December 27th 2018

Red Wine Tops the List of Alcohols Most Reported as Migraine Trigger

Jaime Rosenberg
A study of more than 2000 people with migraine found that red wine was singled out most frequently as a cause of migraine attacks, whereas vodka was indicated least frequently.
Researchers Find Lower Risk of Type 2 Diabetes Among Women With Migraine
December 20th 2018

Researchers Find Lower Risk of Type 2 Diabetes Among Women With Migraine

Jaime Rosenberg
A study found an approximate 30% decrease in the risk of developing type 2 diabetes among women with active migraine.
Increased Monthly Migraine Days Associated With Higher Productivity Loss, Acute Medication Use
December 20th 2018

Increased Monthly Migraine Days Associated With Higher Productivity Loss, Acute Medication Use

David Bai, PharmD
Data from 3 erenumab clinical trials of patients with migraine have identified that an increase in the frequency of monthly migraine days leads to an increase in acute medication use and productivity loss.
Amgen, Magellan Rx Partner to Improve Patient Care for Chronic, Difficult-to-Treat Conditions
December 14th 2018

Amgen, Magellan Rx Partner to Improve Patient Care for Chronic, Difficult-to-Treat Conditions

Jaime Rosenberg
The project will initially focus on improving patient outcomes for 2 conditions: osteoporosis and migraine.
Headache Disorders Play Significant Role in Disability Globally and Require More Attention, Study Finds
December 13th 2018

Headache Disorders Play Significant Role in Disability Globally and Require More Attention, Study Finds

Alison Rodriguez
Exmaning an assessment of data from the 2016 Global Burden of Diseases, Injuries, and Risk Factors study, researchers found that headache disorders, specifically migraine, are important causes of disability worldwide and therefore require more attention in health policy debates and greater resources for research.
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December 13th 2018

Review of Evidence on Noninvasive Vagus Nerve Stimulation for Treatment of Migraine: Efficacy, Safety, and Implications

Mkaya Mwamburi, MD, PhD Andrew T. Tenaglia, BA Eric J. Leibler Peter S. Staats, MD, MBA
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December 13th 2018

Noninvasive Vagus Nerve Stimulation in a Primary Care Setting: Effects on Quality of Life and Utilization Measures in Multimorbidity Patients With or Without Primary Headache

Iain Strickland, PhD, BSc Mkaya Mwamburi, MD, PhD Steven Davis BSc James C.R. Ward, MBBS Janet Day, MBChB Andrew T. Tenaglia, BA Eric J. Leibler Peter S. Staats, MD, MBA
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December 13th 2018

Cost-effectiveness of Noninvasive Vagus Nerve Stimulation for Acute Treatment of Episodic Migraine and Role in Treatment Sequence Strategies

Mkaya Mwamburi, MD, PhD Andrew T. Tenaglia, BA Eric J. Leibler Peter S. Staats, MD, MBA
Study Investigates Extent of Cognitive Impairment in Migraine
December 8th 2018

Study Investigates Extent of Cognitive Impairment in Migraine

Alison Rodriguez
Depression and anxiety can be present with cognitive impairment in migraine, but neither can completely explain it.
Migraine With Aura Associated With Increased Risk of Atrial Fibrillation
December 5th 2018

Migraine With Aura Associated With Increased Risk of Atrial Fibrillation

Jaime Rosenberg
New research finds migraine with aura is associated with an increased risk of atrial fibrillation (AF), which may help provide a clearer picture of the relationship between the migraine subtype and cardioembolic stroke, as AF is a common source of cardioembolic stroke.
Experts Outline Migraine Treatment Choices for Elderly Patients
December 1st 2018

Experts Outline Migraine Treatment Choices for Elderly Patients

Alison Rodriguez
A recent editorial outlined how to choose the necessary migraine pharmacotherapy for an elderly person and emphasized the importance of the careful personalization of treatment based on individual patient characteristics in order to choose a safe and effective migraine treatment.
Study Identifies Association Between Migraine History, Brain Tumors
November 28th 2018

Study Identifies Association Between Migraine History, Brain Tumors

Jaime Rosenberg
According to a new study, prior migraine history is associated with brain tumors. While associated with both sexes, the risk is higher among men than women.
Co-occurrence of Certain Migraine Symptoms Indicates a Common Pathophysiology
November 21st 2018

Co-occurrence of Certain Migraine Symptoms Indicates a Common Pathophysiology

Laura Joszt, MA
Patients who have migraine often suffer from coexisting issues, such as sleep difficulties, vertigo, and dizziness. A study evaluating the presence of certain symptoms in patients with migraine indicated that some may have a common pathophysiology.
Pain Acceptance May Lower Migraine-Related Disability
November 19th 2018

Pain Acceptance May Lower Migraine-Related Disability

Jaime Rosenberg
Following treatment with either a lifestyle intervention or migraine education, patients with migraine had improved pain acceptance and lower migraine-related disability.
Genetic Risk Score May Be Effective for Predicting Migraine Response to Triptans
November 17th 2018

Genetic Risk Score May Be Effective for Predicting Migraine Response to Triptans

Alison Rodriguez
Researchers tested the hypothesis that a genetic risk score based on single-nucleotide polymorphisms may influence headache response to triptans in patients and found a significant relationship between triptan efficacy and the cumulative score of genetic risk.
Use of Narcotics for Migraine Treatment in the ED Has Dropped Significantly
November 13th 2018

Use of Narcotics for Migraine Treatment in the ED Has Dropped Significantly

Jaime Rosenberg
Between 1999-2000 to 2014, the use of IV fluids, dopaminergic receptor antagonists prochlorperazine/metoclopramide, ketorolac, and dexamethasone increased while the use of narcotics decreased.
Headache Specialists Dissatisfied With Migraine Care in the ED
November 11th 2018

Headache Specialists Dissatisfied With Migraine Care in the ED

Alison Rodriguez
Many headache specialists are not satisfied with the care their patients receive in the emergency department (ED), demonstrating the need for more standardized protocols for ED visits by patients with known headache disorders, according to a new study.
Vagus Nerve Stimulation Quickly and Consistently Reduces Pain Intensity, Rescue Medication Use in Migraine
November 9th 2018

Vagus Nerve Stimulation Quickly and Consistently Reduces Pain Intensity, Rescue Medication Use in Migraine

Jaime Rosenberg
Data from a post hoc analysis is adding to positive literature on vagus nerve stimulation, concluding that the treatment quickly and consistently reduced pain intensity while decreasing rescue medication use among patients with episodic migraine.
Review Evaluates Effects of Exogenous Estrogens and Progestogens on Migraine During Reproductive Age
November 3rd 2018

Review Evaluates Effects of Exogenous Estrogens and Progestogens on Migraine During Reproductive Age

Alison Rodriguez
As migraine is significantly more prevalent in women than men—likely due to fluctuations in estrogen levels—researchers conducted a systematic review of data involving the effect of exogenous estrogens and progestogens on the course of migraine during reproductive age, resulting in recommendations for clinical decision making.
Study Determines Link Between Migraine, ADHD in Adults
November 1st 2018

Study Determines Link Between Migraine, ADHD in Adults

Jaime Rosenberg
Following indications of an association between migraine and attention deficit and hyperactivity disorder (ADHD) in children and adolescents, a new study has demonstrated a significant comorbidity of the 2 conditions in adults.
Study Investigates Impact of Migraine on Clinical Presentation of Insomnia
October 26th 2018

Study Investigates Impact of Migraine on Clinical Presentation of Insomnia

Alison Rodriguez
Patients with insomnia had an increased risk of migraine and nonmigraine headache compared to those without insomnia.
Study Finds Sustained Efficacy of Botox for Migraine Over 3 Years
October 22nd 2018

Study Finds Sustained Efficacy of Botox for Migraine Over 3 Years

Jaime Rosenberg
A new study has indicated that long-term treatment with onabotulinumtoxin A is effective, safe, and well-tolerated in the patient population.
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