Lupus

The AJMC® Lupus compendium is a comprehensive resource for clinical news and expert insights for the inflammatory disease that occurs when the immune system attacks its own tissues.

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Top 5 Most-Read Lupus Articles of 2022

December 27th 2022

The top 5 most-read articles on lupus of 2022 included the role of B cells in systemic lupus erythematosus (SLE), the diagnostic journey of women with SLE, future therapies for cutaneous lupus erythematosus (CLE), and more.

Doctor reading a patient report
Case Report Details Rare Case of SLE With Cutaneous Leukocytoclastic Vasculitis

December 14th 2022

Image of person exercising
Physical Activity Benefits People With SLE, but Many Do Not Meet WHO Guidelines

December 10th 2022

Image of genetic code
New Data Suggest Biomarker for SLE Therapy Response

December 6th 2022

graphic depicting lupus
Belimumab Provides Benefit in Cutaneous Lupus Erythematosus, With or Without SLE

November 16th 2022

More News

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July 15th 2022

SLE Recommendations Continue to Evolve as Science Advances

Jared Kaltwasser
A new review article outlines current agreements and disagreements between association guidelines, but notes the recommendations are likely to change more in the future.
Coronavirus graphic
July 12th 2022

COVID-19 Boosters Protective Against Infection, Severe Disease in People With SLE

Jared Kaltwasser
A booster dose of a SARS-CoV-2 vaccine cut infection risk nearly in half, study finds.
Doctor listening to patient
July 3rd 2022

Review: Physicians Must Be Prepared for Wide Range of SLE Presentations

Jared Kaltwasser
A narrative review shows that diagnosing systemic lupus erythematosus (SLE) requires physicians to keep an open and inquisitive mind.
Image of a clinicians performing research
July 2nd 2022

Successive SLE Classification Systems May Help Clarify Mysterious Disease

Jared Kaltwasser
Investigators note that the most recent systemic lupus erythematosus (SLE) classification system has quickly become the gold standard, but disease classification remains challenging.
Image of a group of doctors
June 28th 2022

Nomogram Developed to Predict Lupus Nephritis Outcomes in SLE

Jared Kaltwasser
The tool relies on factors including creatinine, anti–double-stranded DNA antibody, and gender, among others.
Image of scientific research
June 18th 2022

Factors Predictive of Sustained Rituximab Response in Primary Sjögren Syndrome Identified by Study

Jared Kaltwasser
About 43% of patients experienced complete depletion of B cells after the first round of rituximab, and those patients had greater odds of longer-term success.
Image of a pregnant woman
June 15th 2022

Longitudinal Analysis Suggest Pregnancy Outcomes Unchanged in Patients With SLE

Jared Kaltwasser
A single-center analysis of more than 30 years of data shows rates of preterm births and preeclampsia remained stable
Image of lab test tubes
June 11th 2022

Baseline Factors May Predict Overall, Renal Response to Therapy in SLE

Jared Kaltwasser
The investigators cautioned, however, that the factors identified had only modest predictive power.
Image of kidneys
June 9th 2022

Males With Childhood-Onset SLE Face Early, Severe Kidney Involvement

Jared Kaltwasser
The study, based on 33 years of data, also explored auto-antibody production in the rare patient group.
Image of a microscope
June 5th 2022

Combination of Serum NSE, S100B Can Measure Activity in SLE, Study Finds

Jared Kaltwasser
Levels of the 2 markers appeared to indicate both the presence of SLE and disease activity levels.
Image of a hospitalized pregnant patient
June 1st 2022

Analysis Links Risk Factors to Adverse Pregnancy Outcomes in Patients With SLE

Jared Kaltwasser
Forty-two percent of patients in the cohort had an adverse pregnancy outcome.
Analysis Links IFNβ Levels With Severe Lupus Nephritis, Immune Complex Composition in SLE
May 29th 2022

Analysis Links IFNβ Levels With Severe Lupus Nephritis, Immune Complex Composition in SLE

Jared Kaltwasser
Patients with higher levels of interferon-β (IFNβ) in their B cells were less likely to have oral and nasal ulcers or photosensitivity.
sites of lupus involvement
May 23rd 2022

Multi-organ Involvement More Common in Asian, Hispanic Patients With SLE

Jared Kaltwasser
Patients of Asian heritage were also more likely to have end-organ manifestation, the authors found.
woman in pain
May 18th 2022

Severe SLE Flares Negatively Impact Health Care-Related Quality of Life, Study Finds

Jared Kaltwasser
The pain, planning, emotional health, and fatigue quality of life domains were most impacted as a result of severe systemic lupus erythematosus (SLE) flares.
blue graphic of molecules
May 15th 2022

miRNA-499 Gene Polymorphism Tied to Autoimmune Disease Risk, Analysis Shows

Jared Kaltwasser
The study found associations between miRNA-499 polymorphism and autoimmune disease risk in Caucasian and Asian populations, including a significantly increased risk of rheumatoid arthritis and systemic lupus erythematosus.
Image of inflamed skin
May 12th 2022

Higher Lupus-Associated Flare Risk Seen in Patients With Normal-Looking Skin

Jared Kaltwasser
This new research may help investigators prevent skin lesions.
molecules
May 9th 2022

Study Probes Multi-Omics Interactions at Play in SLE Pathogenesis

Jared Kaltwasser
The study highlights differences between patients with systemic lupus erythematosus (SLE) and healthy controls, potentially shedding light on the disease’s underlying mechanisms.
Abstract image of the mind
May 6th 2022

Study: Cognitive Impairment Has Little Effect on QOL in SLE

Jared Kaltwasser
Investigators found quality of life (QOL) effects may be tied to patients’ perceptions of cognitive impairment, rather than objective measurements of impairment from systemic lupus erythematosus (SLE).
Image of blood in test tubes in a lab
May 2nd 2022

Study Shows TLR7 Variation Plays Key Role in SLE Development

Jared Kaltwasser
The study showed that introducing the TLR7 variant in an animal model led to the development of autoimmune symptoms and potential development of systemic lupus erythematosus (SLE).
brain
April 25th 2022

Study: Refractory Headache in Children With SLE Could Be a Sign of Intracranial Hypertension

Jared Kaltwasser
Clinicians should be vigilant and perform neurological and ophthalmological examinations in patients with persistent headaches, the authors said.
diversity graphic
April 21st 2022

Lack of Awareness, Cultural Barriers Impact Racial, Ethnic Groups Hit Hardest by SLE, CLE

Jared Kaltwasser
Patient education is an important step toward improving outcomes for racial and ethnic groups disproportionately affected by lupus, but a new report suggests payers and physicians also have more to learn about the problem.
Image of medical research
April 19th 2022

Role of B1 Cells in SLE Is Better Understood, but Questions Remain

Jared Kaltwasser
A new review article highlights a number of roles for B1 cells, including antibody secretion and the stimulation of CD4+ cells.
Image of a DNA graphic
April 14th 2022

Research Explores Dysregulation of IRF8 in Development of Autoimmune Disease

Jared Kaltwasser
The research could pave the way for therapies that target enhancers of disease-related genes.
Picture of baby at the doctor
April 11th 2022

Study: Pediatric SLE Outcomes Improving, but Racial and Ethnic Disparities Remain

Jared Kaltwasser
Black children with systemic lupus erythematosus (SLE) are at the highest risk of adverse renal outcomes, the study found.
dna
April 3rd 2022

Study: Long-chain Noncoding RNA Expression Correlates with SLE, Inflammation

Jared Kaltwasser
Of 5 RNA investigated, 2 correlated with systemic lupus erythematosus and the last correlated with certain inflammation-related symptoms.
Image of pregnancy
March 27th 2022

Planning Key for Successful Pregnancy in Women With SLE-PAH

Jared Kaltwasser
The report is based on a series of 10 cases and a literature review involving 14 cases.
Image of a genetic code
March 20th 2022

Study: Omega-3 Levels May Play Causal Role in SLE

Jared Kaltwasser
Investigators also studied omega-6, but they found no evidence that it is involved in causing systemic lupus erythematosus (SLE).
Image of a patient in the ICU
March 13th 2022

Mortality High Among Patients With SLE, Pneumonia Requiring ICU Admission

Jared Kaltwasser
The mortality rate for patients with systemic lupus erythematosus (SLE) was greater than one-third if they were admitted to an intensive care unit (ICU).
Image of a doctor looking at a heart readout
March 6th 2022

Study: Incorporating SLE, Corticosteroid Use Enables Better Cardiovascular Risk Assessment

Jared Kaltwasser
The QRISK3 model outperformed more traditional models like the Framingham Risk Score, according to a new report.
Genes and DNA
March 2nd 2022

Type 1 Interferon Status Usually Stable in Patients With Systemic Lupus Erythematosus

Jared Kaltwasser
The results of a new longitudinal analysis cast doubt on the utility of serial interferon assessment.
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