Inflammation

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FDA Approves Dupilumab to Treat EoE for Children Under 12 Years

January 25th 2024

The expanded indication makes dupilumab the only approved treatment for eosinophilic esophagitis (EoE) in this age group.

Vitamin D Concept | image credit: ExQuisine - stock.adobe.com

Vitamin D Supplementation Does Not Significantly Help Psoriasis

By Chelsie Derman

December 28th 2023

Obesity Concept | image credit: high_resolution - stock.adobe.com

Psoriasis Associated with Being Overweight, Obesity, Study Finds

By Chelsie Derman

December 28th 2023

Woman Enduring Arthritic Pain in Hand | image credit: keiferpix - stock.adobe.com

Weight Loss or Gain Not Linked to Outcomes in Hand Osteoarthritis

By Kyle Munz

December 23rd 2023

Top 5 Most-Read Inflammation Content of 2023

By Kyle Munz

December 18th 2023

Recommended Guidelines and Restrictions in Asthma

Defining the recommended guidelines and the formulary restrictions with the standard of care for asthma.

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Use of Biologics for the Treatment of Asthma panelists

Continuing Medical Education

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November 21st 2024

Emerging Concepts and Approaches in the Treatment of Food Allergy: What Managed Care Professionals Need to Know

1.5 Credits / Immunology, Allergy

November 21st 2024

Exploring Innovative Approaches in Myasthenia Gravis and the Specialty Pharmacist’s Role in Optimizing Value-Based Treatment

1.5 Credits / Immunology

November 21st 2024

Treatment Gaps in the Management of Generalized Pustular Psoriasis: Enhancing the Role of Managed Care

1.5 Credits / Dermatology, Immunology

November 21st 2024

Advancing Targeted Therapies Aimed at Smoldering Disease in Multiple Sclerosis

1.0 Credit / Immunology, Neurology

November 21st 2024

Managed Care Insights on the Advances in the Eosinophilic Esophagitis Treatment Landscape

1.0 Credit / Gastroenterology, Immunology, Rare Diseases

November 21st 2024

Managing Patients With COPD: Evidence-Based Care and Optimizing Value of New and Emerging Targeted Therapies

1.0 Credit / Immunology, Pulmonology/Respiratory

November 21st 2024

Managed Care Approaches to Individualize Treatment of Hereditary Angioedema

1.0 Credit / Immunology

November 21st 2024

From Strict Avoidance to Tailored Therapies: Transforming Food Allergy Care

1.5 Credits / Allergy, Immunology

More News

May 19th 2023

Treatment Improves Outcomes in Patients With CRSwNP, Features of Obstructive Lung Disease

Rose McNulty

In the phase 3 SINUS-24 and SINUS-52 trials, dupilumab improved clinical outcomes and and health-related quality of life among patients with chronic rhinosinusitis with nasal polyps (CRSwNP) and clinical features of obstructive lung disease.

May 10th 2023

Patients With EoE Benefit From Systemic Treatment Regardless of Esophageal Dilation History

Rose McNulty

Treatment with dupilumab demonstrated improvements in histological markers, symptoms, and endoscopic markers of eosinophilic esophagitis (EoE) regardless of previous history of esophageal dilation.

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May 6th 2023

Specialty Tertiary Care for CRSwNP Significantly Improves Patient Outcomes

Maggie L. Shaw

Dupilumab treatment delivered at a specialized tertiary care center has great potential to improve patient clinical outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP).

Nasal Polyps: © freshidea - stock.adobe.com

May 3rd 2023

Biologic Shows Positive Outcomes in CRSwNP Regardless of Baseline Asthma Status

Maggie L. Shaw

Chronic rhinosinusitis with nasal polyps (CRSwNP) and asthma are type 2 inflammatory conditions that frequently coexist, the with the latter increasing the symptom burden of the former

Bronchial or windpipe on the woman body and Bronchitis symptoms: © eddows - stock.adobe.com

April 28th 2023

Distal Esophageal Wall Thickness in EoE Independent of Dysphagia Score, Eosinophil Count

Maggie L. Shaw

Investigators wanted to assess endoscopic appearance, wall thickness, histology, and dysphagia score for eosinophilic esophagitis (EoE).

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April 21st 2023

EoE Nonresponders to PPI Treatment May Yet Respond, but More Study Needed

Maggie L. Shaw

A study explored outcomes among patients living with newly diagnosed eosinophilic esophagitis (EoE) who demonstrated lack of histological response following proton pump inhibitor (PPI) treatment.

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April 11th 2023

Mental, Physical QOL From CRSwNP Worse vs General Population

Maggie L. Shaw

Health status and health-related quality of life (QOL) outcomes were compared between patients with severe cases of chronic rhinosinusitis with nasal polyps (CRSwNP) and a general patient population.

April 7th 2023

Study Links Early Pet Exposure, Reduced Food Allergy Incidence in Japanese Children

Rose McNulty

Exposure to pets during fetal development or early infancy was associated with reduced instances of food allergies in young children, with different pet exposures potentially reducing the incidence risk of certain allergen types.

Image Credit: © Karolina Grabowska - Pexels

April 6th 2023

Educational Peanut Allergy Intervention Effective in Implementing Prevention Guidelines

Tim Smith

A research letter highlighted recent findings that iREACH educational intervention training may be helpful in preventing peanut allergies.

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March 30th 2023

Prurigo Nodularis Improves Following Treatment With Dupilumab

Maggie L. Shaw

Despite the approval of dupilumab (Dupixent) in September 2022, there is an ongoing dearth of clinically effective treatments for prurigo nodularis, prompting the present investigation of the monoclonal antibody for the chronic inflammatory skin condition.

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March 20th 2023

Patient Outcomes Improve on Several Fronts Following Treatment for Prurigo Nodularis

Maggie L. Shaw

Subanalyses of data from the LIBERTY PN-PRIME and LIBERTY PN-PRIME2 studies illustrate how dupilumab for prurigo nodularis can better patient outcomes, including quality of life and symptom burden.

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March 16th 2023

Trio of Scales Deemed Valid, Reliable for Use in Prurigo Nodularis

Maggie L. Shaw

The Skin Pain Numeric Rating Scale, Worst-Itch Numeric Rating Scale, and Dermatology Life Quality Index were evaluated for their content validity, fit-for-purpose, and psychometric and measurement properties among patients with the chronic skin disease being treated with dupilumab.

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March 12th 2023

Cluster Analysis Characterizes 2 Distinct Subsets of Prurigo Nodularis

Jaime Rosenberg

Using a clustering algorithm, researchers were able to identify inflammatory and noninflammatory subsets of the disease, which may account for varying responses to certain treatments.

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March 7th 2023

FDA Accepts Application for Dupilumab to Treat Chronic Spontaneous Urticaria

Maggie L. Shaw

The supplemental Biologics License Application was filed for the new indication for dupilumab, which is already approved to treat atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis, and eosinophilic esophagitis.

March 3rd 2023

Different Elimination Diets Produce Comparable Results in EoE

Maggie L. Shaw

The 2 therapies, a 1-food and a 6-food elimination diet both used for eosinophilic esophagitis (EoE), were compared for outcomes after 6 weeks.

February 24th 2023

New Guidance Supports 3 Therapies for CRSwNP

Maggie L. Shaw

In this analysis, evidence was reviewed for the effectiveness of intranasal corticosteroids, biologics, and aspirin therapy after desensitization use among patients who have chronic rhinosinusitis with nasal polyposis (CRSwNP).

February 17th 2023

Are Less-Restrictive Diets Possible Among Patients With EoE? Study Says Yes

Maggie L. Shaw

This review and meta-analysis included 34 studies covering 1762 patients, and investigated the efficacy of 4 varieties of dietary treatment for eosinophilic esophagitis (EoE).

February 6th 2023

Case Highlights EoE With Dysphagia Despite No Asthma, Atopic Disease History

Jared Kaltwasser

Such cases of eosinophilic esophagitis (EoE) are rare, but they can be treated with the typical therapies for EoE.

February 2nd 2023

Periostin Bests Eosinophil Count for Biomarker Predictability in ECRS

Maggie L. Shaw

Known to be a contributing factor to polyp development at high levels, periostin’s potential as a biomarker for eosinophilic chronic rhinosinusitis (ECRS) severity was investigated in a new study in which outcomes were compared between patients who had ECRS and those with non-ECRS.

January 25th 2023

Biomarkers Indicate Potential Need for Chronic Rhinosinusitis Surgery

Maggie L. Shaw

Outcomes were investigated among 541 patients who had chronic rhinosinusitis; they accounted for 435 primary surgeries and 106 revisionist surgeries.

January 20th 2023

Early Diagnosis Vital to Prevent Impairment From Pediatric EGIDs

Maggie L. Shaw

Although it is well studied in adult patients, there is a lack of research on eosinophilic gastrointestinal disorders (EGIDs) among pediatric patients; a recent study aimed to add to the clinical knowledge of EGIDs in younger patients.

January 17th 2023

Adherence to Postop Treatment May Indicate Early Recurrence of CRSwNP

Maggie L. Shaw

The utility of and adherence to follow-up exams for potential recurrence of chronic rhinosinusitis with nasal polyps (CRSwNP) was investigated among 60 patients who had undergone functional endoscopic sinus surgery.

January 11th 2023

Inflammation Biomarker Potential Investigated in New CRSwNP Study

Maggie L. Shaw

Disease outcomes in chronic rhinosinusitis with nasal polyps (CRSwNP) that related to inflammation and endotype specification were goals in this new study that evaluated the biomarker potential of S100A4.

January 7th 2023

Interleukin-13, Periostin Show Potential as Biomarkers in Prurigo Nodularis

Maggie L. Shaw

Levels of certain biomarkers of inflammation in prurigo nodularis were evaluated between patients with and without the chronic inflammatory skin disorder, with the goal of showing potential for precision medicine in prurigo nodularis.

January 6th 2023

Risk of EoE Elevated Following Care for Previous Infection

Maggie L. Shaw

With previous research showing that having a history of infection can lead to loss of autoimmunity, Swedish researchers set out to investigate a potential link between prior infection and development of eosinophilic esophagitis (EoE).

December 31st 2022

Top 5 Most-Viewed Video Interviews of 2022

Pearl Steinzor

This year’s top 5 most-viewed videos include topics on eosinophilic esophagitis (EoE), cancer screening awareness, and racial/ethnic and socioeconomic barriers to care.

Graphic representing top 5 nasal polyps articles for 2022

December 28th 2022

Top 5 Most-Read Nasal Polyps Articles of 2022

Maggie L. Shaw

Nasal polyp development, treatment, and recurrence were topics up for discussion in this year’s most popular nasal polyps–related content.

Image of a consultation between a doctor and a patient

December 24th 2022

Charcot-Leyden Crystals Identified as Potential Biomarker for CRSwNP

Maggie L. Shaw

The biomarker potential of Charcot-Leyden crystals in nasal tissue was investigated over 2 years in 110 patients with diagnosed chronic rhinosinusitis with nasal polyps (CRSwNP).

December 23rd 2022

Study Examines Effect of Biologics on IgE Levels in Urban Settings

AJMC Staff

This study was prompted by recent findings that ultra-low IgE levels (IgE <2.5 kU/L) may be linked with a higher risk of cancers.

The title as a graphic with health icons

December 21st 2022