Hematology

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In a 100-patient clinical practice scenario, cost savings with zanubrutinib vs ibrutinib would amount to $4.7 million. | Image credit: sovova - stock.adobe.com
Zanubrutinib May Lead to Cost Savings vs Ibrutinib in R/R CLL

April 15th 2025

Progression-free survival improvement and drug costs make zanubrutinib a more cost-effective option in relapsed or refractory chronic lymphocytic leukemia (CLL), new research suggests.

Orca-T shows promise to reduce rehospitalization and improve outcomes in MDS and acute leukemias.| Image credit: Eleni - stock.adobe.com
Reduced Rehospitalizations and Potential Cost Savings With Orca-T for Acute Leukemia, MDS

April 11th 2025

The researchers examined outcomes in a series of patients with RT who were treated with liso-cel, including patients who were also taking ibrutinib. | Image credit: AIGen - stock.adobe.com
Ibrutinib May Boost Efficacy of Liso-Cel in CLL With Richter Transformation

April 10th 2025

Recent trials have explored potential strategies for using immunotherapy in chronic lymphocytic leukemia. | Image credit: Spectral-Design - stock.adobe.com
Immune Microenvironment a Key Target in CLL

April 8th 2025

Health equity concept | image credit: VectorMine - stock.adobe.com
Advancing MM Care Through Innovation and Equity: Ajai Chari, MD

April 7th 2025

Expanding Horizons: The Present and Future of Bispecific Antibodies Across Oncology

Experts explore the latest bispecific antibody approvals and clinical applications, discuss barriers in community oncology, address management of cytokine release syndrome, and consider how these therapies can expand patient access to care.

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October 18th 2018

Study Summary: The Role of Race and Ethnicity in Disease and Outcome Disparities in Multiple Myeloma

Ailawadhi S, Jacobus S, Sexton R, et al., outcome disparities in multiple myeloma: exploring the role of race/ethnicity in the Cooperative Group clinical trials. Blood Cancer J. 2018, 8(7):67. doi: 10.1038/s41408-018-0102-7.
Giant Acute Myeloid Leukemia Data Set Offers a Leap Forward in Matching Therapies to Patients
October 18th 2018

Giant Acute Myeloid Leukemia Data Set Offers a Leap Forward in Matching Therapies to Patients

Mary Caffrey
Researchers have created a database that shows how 409 different tumor cells respond to 122 therapies, which will allow clinical trials to proceed for this aggressive blood cancer.
Three Genetic Types Drive Higher Prevalence of MM in African Americans
October 14th 2018

Three Genetic Types Drive Higher Prevalence of MM in African Americans

Laura Joszt, MA
Multiple myeloma (MM) occurs 2 to 3 times more frequently in Americans of African descent than in Americans of European descent, and a new study has identified 3 gene types that account for this disparity.
Tisagenlecleucel's High Price Aligns With Its Benefit in Pediatric B-ALL, Study Finds
October 11th 2018

Tisagenlecleucel's High Price Aligns With Its Benefit in Pediatric B-ALL, Study Finds

Laura Joszt, MA
Tisagenlecleucel's high price is aligned with the benefit the chimeric antigen receptor T-cell therapy provides over a patient's life. Approximately 40% of patients treated are expected to be long-term survivors.
Can Flipping a Genetic Switch Help Treat a Common Childhood Leukemia?
October 10th 2018

Can Flipping a Genetic Switch Help Treat a Common Childhood Leukemia?

Mary Caffrey
Research at the University of Washington is exploring the possibility of triggering one gene to take over the function of another with a common mutation that triggers acute lymphoblastic leukemia.
Blood Publishes Results Showing Patients With Hard-to-Treat Leukemia, Lymphoma Show Marked Response With Duvelisib
October 8th 2018

Blood Publishes Results Showing Patients With Hard-to-Treat Leukemia, Lymphoma Show Marked Response With Duvelisib

Mary Caffrey
The dual inhibitor first blocks 2 kinases that are known to aid the growth of malignant B cells, and then it disrupts the microenvironment that supports tumor growth.
FDA Approves Once-Weekly Dose of Kyprolis for R/R Multiple Myeloma
October 3rd 2018

FDA Approves Once-Weekly Dose of Kyprolis for R/R Multiple Myeloma

Laura Joszt, MA
A once-weekly dose of carfilzomib (Kyprolis) in combination with dexamethasone has been approved to treat patients with relapsed or refractory (R/R) multiple myeloma. The approved regimen improved progression-free survival and had a better overall response rate than a twice-weekly regimen.
Working Toward CAR T-Cell Treatments With Fewer Side Effects
September 30th 2018

Working Toward CAR T-Cell Treatments With Fewer Side Effects

Mary Caffrey
Loyola University Chicago and Loyola Medicine announced plans this week to develop their own chimeric antigen receptor T-cells that would have less toxic side effects.
Researchers Identify New Cancer Cell That Is Key to Relapse in AML
September 23rd 2018

Researchers Identify New Cancer Cell That Is Key to Relapse in AML

Laura Joszt, MA
Cancer-regenerating cells that arise after chemotherapy have been identified as a new type of cancerous cell that is responsible for the return of acute myeloid leukemia (AML) after remission.
Patient Stress Is Linked With Cancer Cell Proliferation and Elevated Cytokines in CLL
September 19th 2018

Patient Stress Is Linked With Cancer Cell Proliferation and Elevated Cytokines in CLL

Kelly Davio
While it is well understood that psychological distress is a major side effect of cancer and its treatment, and that stress can have a strong impact on patients’ quality of life, a new study indicated that stress is linked with markers of more advanced disease in patients with chronic lymphocytic leukemia (CLL), the most common form of leukemia among adults.
Insurance Status Matters in Follicular Lymphoma, Study Finds
September 18th 2018

Insurance Status Matters in Follicular Lymphoma, Study Finds

Mary Caffrey
Lower socioeconomic status is associated with poor survival in lymphoma.
Hispanic Children With ALL at Greater Risk of Neurotoxicity During Treatment
September 16th 2018

Hispanic Children With ALL at Greater Risk of Neurotoxicity During Treatment

Laura Joszt, MA
Children of Hispanic ethnicity have a higher risk of developing neurotoxicity when they are treated with methotrexate for acute lymphoblastic leukemia (ALL) compared with non-Hispanic white children.
This Week in Managed Care: September 14, 2018
September 14th 2018

This Week in Managed Care: September 14, 2018

This week, the top managed care news included medical groups asking CMS to halt or slow down its plans to cut physician reimbursement for evaluation and management services; the Senate weighs a package of bills to combat the opioid epidemic; new research shows the Affordable Care Act pushed the uninsured rate down to 10%.
Preventing Transportation of Mutant Protein Can Inhibit Growth of Leukemic Cells
September 13th 2018

Preventing Transportation of Mutant Protein Can Inhibit Growth of Leukemic Cells

Laura Joszt, MA
Researchers at Baylor College of Medicine have found that preventing a mutated protein from leaving the nucleus and traveling to the cytoplasm of the cell can help inhibit the growth of leukemic cells in acute myeloid leukemia.
Prescription Drug Coverage Improved Survival for Patients With MM
September 9th 2018

Prescription Drug Coverage Improved Survival for Patients With MM

Laura Joszt, MA
Patients with multiple myeloma (MM) who are enrolled in a Medicare Part D plan or other creditable prescription drug coverage have better survival than patients without prescription drug coverage. According to a study in Journal of Clinical Oncology, this improved survival seemed to be a result of patients having access to all treatment options.
Amgen Seeks Expanded Indication for Once-Weekly Kyprolis for Multiple Myeloma
September 4th 2018

Amgen Seeks Expanded Indication for Once-Weekly Kyprolis for Multiple Myeloma

Laura Joszt, MA
Amgen has submitted a supplemental New Drug Application to the FDA to expand the prescribing information of carfilzomib (Kyprolis) to include a once-weekly dosing option in combination with dexamethasone for patients with relapsed or refractory multiple myeloma.
FDA Approves New Drug for Adults and Adolescents With Hemophilia A
September 2nd 2018

FDA Approves New Drug for Adults and Adolescents With Hemophilia A

Laura Joszt, MA
A new long-acting treatment for hemophilia A has been approved for previously treated patients, aged 12 years and older. Bayer’s Jivi was also approved for on-demand treatment and the perioperative management of bleeding in the same population.
Patients With Blood Cancer Less Likely to Understand Diagnosis Compared With Other Cancers
August 31st 2018

Patients With Blood Cancer Less Likely to Understand Diagnosis Compared With Other Cancers

Laura Joszt, MA
A survey of patients in the United Kingdom who were diagnosed with cancer found that patients with blood cancers were the least likely to say they completely understood what was wrong when the doctor explained it. They were also less likely to say that their treatment options were explained before treatment started compared with patients with other cancers.
Childbirth Rates for Female Survivors of Hodgkin Lymphoma Similar to General Population
August 28th 2018

Childbirth Rates for Female Survivors of Hodgkin Lymphoma Similar to General Population

Laura Joszt, MA
As cure rates for young patients with Hodgkin lymphoma (HL) improve, the historically negative impact of treatments has to be considered. However, a new study has found that over time, childbearing rates for female survivors of HL have improved to the point of approaching the rates of the general population.
Dose-Confirmation Study for Hemophilia B Gene Therapy Underway
August 24th 2018

Dose-Confirmation Study for Hemophilia B Gene Therapy Underway

Laura Joszt, MA
The first patient has been treated in a phase 2b dose-confirmation study of AMT-061, an investigational gene therapy for the treatment of patients with severe and moderately severe hemophilia B. Once the dosing of AMT-061 is confirmed, the safety and efficacy of the therapy will be evaluated in the global phase 3 HOPE-B clinical trial.
Tracking ctDNA Levels Can Quickly Predict Response to Lymphoma Therapy
August 22nd 2018

Tracking ctDNA Levels Can Quickly Predict Response to Lymphoma Therapy

Laura Joszt, MA
A blood test that tracks the rise and fall of circulating tumor DNA (ctDNA) levels can predict how patients with diffuse large B-cell lymphoma will respond to therapy within days of starting treatment.
AI Platform Can Identify Personalized Drug Combinations to Treat Multiple Myeloma
August 16th 2018

AI Platform Can Identify Personalized Drug Combinations to Treat Multiple Myeloma

Laura Joszt, MA
A new technology platform utilizing artificial intelligence (AI) could change how drug combinations are designed and help doctors to identify optimal personalized drug combinations for patients with multiple myeloma.
New Biologic Approved to Treat 2 Rare Types of Non-Hodgkin Lymphoma
August 13th 2018

New Biologic Approved to Treat 2 Rare Types of Non-Hodgkin Lymphoma

Laura Joszt, MA
The FDA has approved a new drug to treat 2 rare types of non-Hodgkin lymphoma based on phase 3 clinical trial results that found mogamulizumab-kpkc improved progression-free survival and had a higher overall response rate compared with the chemotherapy vorinostat.
Progress Has Eased Burden on Patients With Blood Cancers, but More Change Is Needed, LLS Reports
August 10th 2018

Progress Has Eased Burden on Patients With Blood Cancers, but More Change Is Needed, LLS Reports

Laura Joszt, MA
A progress report from the Leukemia & Lymphoma Society highlighted policy measures that have eased the burden on patients, but also noted where more work is needed.
AYAs With Hodgkin Lymphoma Face Additional Burdens With Current Clinical Trial Designs
August 8th 2018

AYAs With Hodgkin Lymphoma Face Additional Burdens With Current Clinical Trial Designs

Laura Joszt, MA
Advances in Hodgkin lymphoma treatment has led to high survival rates, but adolescents and young adults, who represent the largest age group affected by the disease, face lifelong morbidities from clinical trials. New analytic methods could help inform future protocol changes.
AYAs With Blood Cancers Face Unique Psychosocial Issues That Impact Quality of Life
August 3rd 2018

AYAs With Blood Cancers Face Unique Psychosocial Issues That Impact Quality of Life

Laura Joszt, MA
In addition to survival among adolescents and young adults (AYAs) with hematological malignancies lagging behind that of children and older adults, AYAs also face unique challenges related to their physical, psychosocial, and economic circumstances.
Interventions for AML After Relapse Work Best in Patients Who Achieved CR
July 30th 2018

Interventions for AML After Relapse Work Best in Patients Who Achieved CR

Laura Joszt, MA
Treatment options for patients with acute myeloid leukemia (AML) who relapse after an allogeneic hematopoietic cell transplant (allo-HCT) are limited, but those who are able to receive intensive interventions receive a second allo-HCT or donor lymphocyte infusion. A study in JAMA Oncology sought to compare the 2 options for patients who relapse.
Addressing Unmet Needs in Multiple Myeloma
July 25th 2018

Addressing Unmet Needs in Multiple Myeloma

Second Myeloma Relapse and Beyond: Upcoming Strategies
July 25th 2018

Second Myeloma Relapse and Beyond: Upcoming Strategies

Selecting Treatment at First Relapse of Multiple Myeloma
July 25th 2018

Selecting Treatment at First Relapse of Multiple Myeloma

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