FDA Approves New Immunotherapy Combination for Relapsed/Refractory Multiple Myeloma
Today, the FDA approved elotuzumab (Empliciti), an injection for intravenous use in combination with pomalidomide and dexamethasone (EPd) for the treatment of adult patients with multiple myeloma who have received at least 2 prior therapies.
Pembrolizumab Plus Chemotherapy Approved to Treat Metastatic Squamous NSCLC
Earlier this week, the FDA approved pembrolizumab (Keytruda) in combination with carboplatin and either paclitaxel or nab-paclitaxel for the first-line treatment of patients with metastatic squamous non-small cell lung cancer (NSCLC).
Palbociclib Plus Fulvestrant Increases OS in HR+, HER2-Negative Breast Cancer
A recent trial sought to assess the effect of palbociclib on overall survival (OS) and the efficacy of subsequent therapy in patients with hormone receptor–positive (HR+), HER2-negative advanced breast cancer.
Opdivo Fails to Meet Primary Endpoint in Phase 3 SCLC Trial
Last week, Bristol-Myers Squibb announced results from the phase 3 CheckMate -331 trial that investigated nivolumab (Opdivo) versus the current standard of care, chemotherapy, in the treatment of patients with small cell lung cancer (SCLC) who relapsed following platinum-based chemotherapy. The trial found that nivolumab did not significantly increase overall survival compared with chemotherapy.
Medical Marijuana in Cancer Treatment: No Standards of Care, and So Far, No Coverage
Over the past decade, both recreational and medical marijuana use in the United States has grown tremendously. However, disputes surrounding the legal and ethical implications, safe administration, dispensing, health consequences, and therapeutic indications– albeit based on very limited clinical data– related to its usage abound.
FDA Approves Libtayo to Treat Second Most Common Skin Cancer
Last week, the FDA granted approval to immune checkpoint inhibitor cemiplimab-rwlc, to be sold as Libtayo, for the treatment of metastatic cutaneous squamous cell carcinoma (CSCC), or in patients with locally advanced CSCC who are not candidates for curative surgery or curative radiation.
Adherence to NCCN Breast Cancer Guidelines Improves Outcomes
In a study presented at the American Society of Clinical Oncology Quality Care Symposium last month, researchers looked to assess the adherence to National Comprehensive Cancer Network (NCCN) guidelines in the neoadjuvant treatment of breast cancer and the impact on outcomes.
Lack of Discussion Around Cancer Treatment Costs Leads to Financial Toxicity
Earlier this week, 3 studies were released that investigated the financial difficulties seen in patients living with cancer. Such difficulties are referred to as “financial toxicity,” which was studied in patients with metastatic breast cancer and older patients, as well as the conversations about cost of care that women with breast cancer have with their physicians.
Imfinzi Plus Chemotherapy Reduced Risk of Death by One-Third in Stage III NSCLC
Earlier this week, drug manufacturer Astrazeneca announced the results from a phase 3 trial studying durvalumab (Imfinzi) among patients with stage III unresectable non­–small cell lung cancer (NSCLC) who did not have disease progression after concurrent chemoradiotherapy.
More Data Necessary to Determine Best Treatment Option in Basal Cell Carcinoma
Although many different treatments exist for basal cell carcinoma (BCC), many methods have not been compared in head-to-head randomized trials. A review recently published in Annals of Internal Medicine looked to evaluate the comparative effectiveness and safety of treatments in adults with BCC.
Keytruda Earns Priority Review as Monotherapy in NSCLC
Last week, the FDA granted priority review to a new supplemental Biologics License Application for pembrolizumab (Keytruda) as a monotherapy for first-line treatment of locally advanced or metastatic nonsquamous or squamous non–small cell lung cancer (NSCLC) in patients whose tumors express PD-L1 without EGFR or ALK mutations.
NCCN Report on CAR T-Cell Therapy, Recommendations for Future Use
A recent report from the National Comprehensive Cancer Network (NCCN) investigated the current state of chimeric antigen receptor (CAR) T-cell therapy and future strategies to consider as the novel immunotherapy evolves and is used in the treatment of more patients.
NCCN Releases New Guidelines for Most Common Gynecologic Cancer
The National Comprehensive Cancer Network (NCCN) released this week new treatment guidelines for patients for 2 uterine cancers, endometrial cancer, the most common gynecologic cancer, and a rare cancer called uterine sarcoma.
EU Approves Keytruda for First-Line Treatment of Metastatic Nonsquamous NSCLC
Pembrolizumab (Keytruda) earned European approval this week, in combination with platinum-based pemetrexed, for the first-line treatment of metastatic nonsquamous non-small cell lung cancer (NSCLC) in adults whose tumors lack EGFR or ALK mutations.
UIC Releases First Guidelines to Diagnose and Treat Perimenopausal Depression
A team of multi-institutional clinicians and scientists have recently published the first-ever guidelines for the evaluation and treatment of perimenopausal depression, endorsed by the International Menopause Society, in Menopause and the Journal of Women’s Health.
Women More Likely to Survive Heart Attacks When Treated by Female Physicians
A recent review of nearly 582,000 heart attack cases over the span of 19 years found that female patients had a significantly higher survival rate when treated by a female physician in the emergency department.