Christina Mattina

As increasing evidence suggests that a disrupted sleep-wake cycle can drive the development of Alzheimer disease and other neurocognitive disorders via β-amyloid accumulation, a new study finds that the association between β-amyloid accumulation and cognitive impairment can be mediated by sleep disruption even after the onset of cognitive decline.

Veterans with posttraumatic stress disorder (PTSD), whether or not they had experienced a traumatic brain injury (TBI), were more likely to experience rapid eye movement (REM) sleep behavior disorder than veterans without TBI or PTSD, according to the findings of a new study.

Several species of bacteria that can transmit respiratory infections have varying levels of response to the disinfecting agents used in municipal water treatment systems, with no one water disinfection strategy achieving complete microbial control, according to new findings.

Using and adhering to positive airway pressure therapy was associated with fewer inpatient and overall acute care visits and a lower likelihood of having costs from those visits among patients with moderate or severe obstructive sleep apnea.

The aim of this study was to assess cytokine levels in patients with refractory chronic rhinosinusitis with nasal polyps and to identify inflammatory markers associated with certain subtypes.

An in-press study detailed the characteristics of 4 asthma endotypes and their association with asthma-related healthcare outcomes and responsiveness to treatment.

A study of college students found that better sleep—specifically, higher quality, longer duration, and greater consistency of sleep—was associated with higher scores on quizzes and midterm exams.

Children with spinal muscular atrophy (SMA) who require noninvasive ventilation had more severe impairments in respiratory function than those who do not, according to findings of a new study.

According to results of a survey asking 1300 Americans about their perceptions and knowledge of sleep disorders like narcolepsy, many respondents were not familiar with common symptoms of the disease and their understanding was often shaped by television shows or movies.

According to findings from a cohort study, patients with obstructive sleep apnea were more likely than healthy controls to develop depressive and anxiety disorders over a 9-year follow-up.

Results from 2 large clinical trials show that dupilumab is associated with clinical improvements in symptoms of chronic rhinosinusitis (CRS) with nasal polyps.

A recent Peer Exchange series from The American Journal of Managed Care® brought together a panel of experts to discuss spinal muscular atrophy (SMA), including its clinical presentation, diagnosis of its various types, and the potential of new disease-modifying treatments. The panel was moderated by Peter L. Salgo, MD.

Individuals with HIV are often susceptible to opportunistic pulmonary infections, but the lung lesions resulting from these infections can be mistaken for lung cancer, according to a new study that aimed to characterize features of OPIs versus tumors in patients with HIV.

The importance of sleep is magnified for patients with Alzheimer disease (AD), who commonly experience sleep disturbances due to changes in their neurotransmitter systems. However, the impact of AD and other dementias on sleep is also seen among caregivers of patients with dementia.

The September issue of The American Journal of Managed Care® (AJMC®) featured research on federal healthcare reform that detailed innovative ideas in Medicare, Medicaid, and the Veterans Affairs health system. Here are 5 findings from research published in the issue.

In a new study, researchers compared the associations between several measures of breathing patterns during sleep and daytime sleepiness related to obstructive sleep apnea (OSA). They found that nighttime oxygen desaturation severity was a strong predictor of sleepiness.

A ratio of sinus scores calculated based on computed tomography (CT) imaging can accurately predict the recurrence of chronic rhinosinusitis (CRS) with nasal polyps, according to new findings.

A guideline update issued by the American Academy of Neurology states that patients with multiple sclerosis (MS) should receive all recommended vaccinations unless contraindicated.

In individuals undergoing hip arthroscopy in the Military Health System, a diagnosis of sleep apnea or insomnia after the surgery was associated with chronic opioid use, more healthcare visits, and higher medical costs.

Using a body-worn sensor to detect falls at home is feasible for elderly individuals, including those with Parkinson disease, who have a higher risk of falling, according to new study findings.

Results of a subgroup analysis within a randomized, controlled trial show that the monoclonal antibody dupilumab (Dupixent) improved clinical and patient-reported outcomes among patients with chronic rhinosinusitis (CRS) with nasal polyps and comorbid asthma.

A study of pairs of twins revealed that obstructive sleep apnea and measures of the disorder seem to be heritable, but daytime sleepiness is mostly influenced by environmental factors.

A new study has found a dose-dependent relationship between coffee consumption and reduced severity of tremors in men with Parkinson disease.

Prior to the launch of solriamfetol (Sunosi) for narcolepsy and obstructive sleep apnea, the Drug Enforcement Administration designated it as a Schedule IV drug, indicating that it has a low potential for abuse and a low risk of dependence. Around the same time, results from the phase 3 TONES 3 study were published, showing the drug’s efficacy in increasing wakefulness and reducing sleepiness.

The August issue of The American Journal of Managed Care® (AJMC®) featured research on surprise medical billing policies, social determinants of health, and the value of chimeric antigen receptor T-cell therapies, among other topics. Here are 5 findings from research published in the issue.

Researchers aiming to better understand the role of estrogen in the development of Parkinson disease (PD) and its potential as a treatment found that brain-selective estrogen therapy resulted in motor improvements in male mice with PD-like symptoms.

The clinical manifestations of symptoms experienced by children and adolescents with narcolepsy can differ from those seen in adults, presenting barriers to a timely diagnosis.

An analysis of patients’ and caregivers’ willingness to participate in genetic studies on Parkinson disease found that although overall levels of motivation were similar in Hispanic and non-Hispanic patients, the reasons behind this interest varied between the groups.

In a phase 3 study, solriamfetol demonstrated both safety and efficacy in patients with narcolepsy. The selective dopamine and norepinephrine reuptake inhibitor has a mechanism of action different from other wake-promoting agents.

Findings of a retrospective study show that comorbid psychosis and depression in patients with Parkinson disease are associated with greater disease severity and higher healthcare utilization.