Trial Evaluates Effect of Nebulized Glycopyrrolate With, Without LABA in COPD
Previous phase 3 studies have demonstrated the efficacy of nebulized glycopyrrolate inhalation solution (GLY) for treating patients with chronic obstructive pulmonary disease (COPD). In a recent study, researchers conducted a secondary analysis and found that nebulized GLY demonstrated efficacy and was well tolerated for up to 48 weeks in subjects with COPD with or without background long-acting beta2-agonist (LABA).
Study Finds Gaps in Medicaid Coverage Guidelines for Asthma Care
A study found a lack of consistent and comprehensive coverage throughout the country, identified coverage-related challenges to accessing asthma care within states, and found substantial gaps between guidelines-based asthma care and coverage by state Medicaid programs.
Review Assesses Impact of Seasonality in COPD
Patients with chronic obstructive pulmonary disease (COPD) often have a significant disease burden that is particularly associated with the peak incidence of exacerbation events during winter months. A review assessed previous population studies that evaluated the impact of seasonality in COPD, emphasizing the importance of understanding how all factors impact patients and where interventions can be targeted.
Embarrassment Contributes to Poor Asthma Treatment Adherence, Study Finds
Despite there being effective therapies, asthma is commonly poorly controlled. Acknowledging and addressing patient treatment beliefs and perceptual barriers to adherence to asthma medication is necessary for designing adherence interventions for patients.
Prolonged Aura in Migraine Is Frequent, Similar to Other Auras
A recent study has found that prolonged auras are common and are phenotypically similar to other auras. Based on the observed duration of aura symptoms, the researchers suggest reconsidering the use of the term “prolonged aura."
Genetics Study Finds Bone Mineral Density, Not Vitamin D, Significantly Affects Fracture Risk
A study investigating the genetic determinants of fracture risk identified 15 genetic determinants of fracture, which also influenced bone mineral density. Among the clinical risk factors considered, only bone mineral density demonstrated a major causal effect on fracture, while genetic predisposition to lower levels of vitamin D and estimated calcium intake from dairy were not associated with fracture risk, according to the results.
Blood Eosinophils Threshold Could Predict ICS Treatment Response for COPD
There is an increased need for potential biomarkers that can identify patients with chronic obstructive pulmonary disease (COPD) who will benefit from treatment involving inhaled corticosteroids (ICS). According to a recent study, the 2% threshold for blood eosinophils could accurately predict ICS treatment response in patients with COPD, but the risk of pneumonia was increased.
Genetic Profile and Proximity to Roadways Affect Asthma Symptoms, Study Finds
Patients with asthma with certain genotype combinations demonstrate more intense symptoms when combined with a close proximity to roadways, suggesting that traffic-related air pollution exposure may affect the likelihood of asthma diagnosis and exacerbations.
Assessing Denosumab's Effects on BMD in Women With Breast Cancer
Twice-yearly treatment with denosumab, a fully human monoclonal antibody, may be associated with increased bone mineral density (BMD) among patients who receive adjuvant aromatase inhibitors (AIs) therapy, according to a recent study.
Implementing Effective COPD Telerehabilitation Must Involve Staff, Study Finds
Telerehabilitation (TR), defined as telecare that involves supervised online exercise sessions for patients with chronic obstructive pulmonary disease (COPD), is beneficial for symptom relief, physical function, and quality of life. A recent study found that specific attention toward the involvement of health professionals in the decision process combined with education and skill training is essential to support the successful implementation of TR.
Phase 2 STARS Trial Results Demonstrate Efficacy of OV101 for Treating Angelman Syndrome
Ovid Therapeutics Inc., a biopharmaceutical company, recently announced that the phase 2 STARS trial, which tested the efficacy of the investigational drug OV101, achieved its primary endpoint of safety and tolerability for treating Angelman syndrome.
Chronic Rhinitis Significantly Associated With Early Hospital Readmission Rates for Asthma and COPD
Early hospital readmissions for patients with asthma and chronic obstructive pulmonary disease (COPD) represent a major economic burden within the healthcare system and recent research found that comorbid chronic rhinitis is significantly associated with 30-day asthma and COPD related readmissions
Human–Machine Hybrid Predictions Led to Better Prognoses of MS, Study Finds
Researchers evaluating the different methods used to predict the progression of multiple sclerosis (MS) found that human–machine hybrid predictions led to better prognoses than did machine learning algorithms or groups of humans alone.
Rare Lymphocyte May Be Effective in Treatment During Onset of Inflammatory Arthritis
Group 2 innate lymphoid cells, a rare form of lymphocyte that defend the body from pathogens, may have immune-regulatory functions in rheumatoid arthritis and play a key role in the development of inflammatory arthritis, according to immunologists at Friedrich-Alexander-Universität Erlangen-Nürnberg.
Mapping the Nervous System May Shed Light on the Origin of Different Neurological Diseases
Researchers recently developed a systematic map of the cell types that make up the mouse nervous system which has the ability to reveal new information about the origin of neurological diseases, and may lead to a detailed map of the human brain.