Gerard Criner, MD, FACP, FACCP, professor and founding chair, Thoracic Medicine and Surgery, at the Lewis Katz School of Medicine at Temple University, discusses a new trial that investigated how long treatment would last for patients with emphysema, and if any complications arose.
Patients with emphysema had an opportunity to participate in a long-term trial, allowing outcomes to be measured over years instead of months, said Gerard Criner, MD, FACP, FACCP, professor and founding chair, Thoracic Medicine and Surgery, at the Lewis Katz School of Medicine at Temple University.
Today at the at the 2023 American Thoracic Society International Conference, Criner presented long-term data on the EMPROVE trial, which investigated benefits of the Spiration Valve System in patients who have emphysema.
Transcript
Why did you decide to study this topic?
Patients with emphysema suffer from hyperinflation, and that hyperinflation has a significant contribution to the morbidity and mortality of the disease. Over the last 20 years, various attempts of trying to decrease the degree of hyperinflation have included medicines, plus other surgical and less-invasive forms of therapy. There are bronchoscopic techniques; the ones that are approved in the United States are in the endobronchial valves. [The] EMPROVE study was a prospective randomized multicenter controlled trial that was conducted in patients who were hyperinflated with emphysema to see if lobar occlusion could decrease the amount of air trapping and could result in improving the patient outcome measured by improvements in lung function, quality of life, [and] reduction in shortness of breath.
Most of the therapies that have looked at this range of treatments are really focused at patients that are 3 months, 6 months, 12 months in outcome. But when it's brought into clinical practice, the questions that patients ask and providers ask, [is] “How long do these effects last?”
So, the genesis of this long-term evaluation was a look at the durability of the treatment effect, see if it remains, as well as looking at the complications as a result of the therapy in a cohort of patients that were followed up to 5 years after the treatment.
ATS 2024: Bridging the Past, Present, and Future of Respiratory Care
May 16th 2024The application of artificial intelligence in medicine is anticipated as a highlight of ATS 2024, with sessions exploring its applications in research, radiological interpretation, and pediatric pulmonology.
Read More
Frameworks for Advancing Health Equity: Urban Health Outreach
May 9th 2024In the series debut episode of "Frameworks for Advancing Health Equity," Mary Sligh, CRNP, and Chelsea Chappars, of Allegheny Health Network, explain how the Urban Health Outreach program aims to improve health equity for individuals experiencing homelessness.
Listen
Tackling Health Inequality: The Power of Education and Experience
April 30th 2024To help celebrate and recognize National Minority Health Month, we are bringing you a special month-long podcast series with our Strategic Alliance Partner, UPMC Health Plan. Welcome to our final episode of this limited series and our conversation with Janine Jelks-Seale, MSPPM, director of health equity at UPMC Health Plan.
Listen
Posters Characterize DMD Caregiver Experiences, Impact of Gene Therapy on Caregiving Demands
May 10th 2024Posters presented at the ISPOR—The Professional Society for Health Economics and Outcomes Research meeting explored Duchenne muscular dystrophy (DMD) caregiver experiences and gene therapy’s impact on work opportunities for caregivers.
Read More