Patients often have comorbidities that make it important to consider them holistically and not bucket them into one disease state, and the findings on rivaroxaban show broad benefits and a favorable risk-benefit profile, said Marc Bonaca, MD, MPH, of CPC Clinical Research and CPC Community Health and the University of Colorado School of Medicine.
Patients often have comorbidities that make it important to consider them holistically and not bucket them into one disease state, and the findings on rivaroxaban show broad benefits and a favorable risk-benefit profile, said Marc Bonaca, MD, MPH, executive director of CPC Clinical Research and CPC Community Health and director of vascular research, associate professor of medicine, and the William R. Hiatt Endowed Chair in Cardiovascular Research at the University of Colorado School of Medicine.
Transcript
Why is it important to know that benefits for rivaroxaban are the same regardless of chronic kidney disease (CKD) status?
Clinicians are always struggling with risk-benefit, and we look at trials and then we try to understand how to individualize it to our patients. A lot of clinicians are worried about the patient with comorbid kidney disease about bleeding, and about whether there are different risk-benefit profiles in patients who have PAD [peripheral artery disease] and CKD. And here, we clearly see that there's a very robust benefit and that the bleeding is consistent between the groups, so there's no effect modification for chronic kidney disease.
So, the take home is that the risk-benefit, the favorable risk-benefit for rivaroxaban is entirely consistent with and without chronic kidney disease, and we shouldn’t withhold an effective therapy from this population.
There's been more emphasis in recent years to consider cardiometabolic and renal treatment holistically. How do these new data on rivaroxaban align with that trend?
Well, we have to treat our patients, not disease states. And sometimes we think about, well, this is a kidney patient or peripheral artery patient or coronary patient, but really, these are people. These are patients, and these are family members, and they have all these comorbidities, I think we have to consider holistically the benefits of our therapies and the risks and not put them into buckets.
And so, I think, when I consider therapies in the clinic, I like to think about, what is the holistic benefit? Is it just for MACE [major adverse cardiovascular events]? Is it just for heart failure? Or are there other benefits? And I think we see rivaroxaban is one of those therapies that has broad benefits. That it's not just coronary events, not just stroke, but it's amputation limb events, too. And for the patient with PAD, we have to consider all of those outcomes when we think about therapies.
Persistence Pays Off With Zanubrutinib: A Challenging CLL Case With a Prior BTK Inhibitor Failure
May 10th 2024The case of a 77-year-old woman with a long chronic lymphocytic leukemia (CLL) history illustrates the novel use of zanubrutinib as a potential option for some patients who have failed first-generation Bruton tyrosine kinase (BTK) inhibitors and venetoclax.
Read More
Frameworks for Advancing Health Equity: Urban Health Outreach
May 9th 2024In the series debut episode of "Frameworks for Advancing Health Equity," Mary Sligh, CRNP, and Chelsea Chappars, of Allegheny Health Network, explain how the Urban Health Outreach program aims to improve health equity for individuals experiencing homelessness.
Listen
Looking Back on ISPOR 2024: Hot Policy Topics, Welcome Focus on Employers, and More
May 10th 2024Kimberly Westrich, MA, chief strategy officer of the National Pharmaceutical Council, reflects on the most valuable learnings from the 2024 meeting of ISPOR—The Professional Society for Health Economics and Outcomes Research, including lively discussions of the Inflation Reduction Act and workshops on value assessment.
Read More
Tackling Health Inequality: The Power of Education and Experience
April 30th 2024To help celebrate and recognize National Minority Health Month, we are bringing you a special month-long podcast series with our Strategic Alliance Partner, UPMC Health Plan. Welcome to our final episode of this limited series and our conversation with Janine Jelks-Seale, MSPPM, director of health equity at UPMC Health Plan.
Listen