Clinical

Targeting cancer stem cells could have a much better impact on the outcome of patients with multiple myeloma being treated with standard chemotherapy, a new single-arm study by researchers at Johns Hopkins has found.

Data on drug prescriptions, diagnoses, and events are increasingly being used for epidemiologic and pharmacologic studies and for the evaluation of quality of care, but questions arise about how complete and accurate the diagnoses and events in these databases are.

Despite the fundamental advances in cancer care technology and care delivery that have made these improvements possible, our delivery system remains quite inefficient and frequently falls short of being truly patient-centered. Is a system-based solution the answer?

Study finds a first heart attack is more likely to lead to heart failure in patients when the burden of coronary artery disease increases.

Many physicians are interested in using genomic profiling in patient care, but many believe they are unprepared to do so.

Pharmaceutical industry experts provide an overview of the highly complex biosimilar development process at The Community Oncology Conference: Innovation in Cancer Care, held in Orlando, Florida.

An overview of the oncology clinical pathways development program at the UPMC CancerCenter and how it led to the creation of Via Oncology, a clinical pathways vendor.

What we're reading, April 15, 2016: troubling disparities in access to preventive care remain; new test to choose the right hepatitis C medication could save money; and upcoming loss of exclusivity for some drugs could mean big savings for the healthcare system.

Representatives from 3 clinics that successfully participated in the Commission on Cancer accreditation process for the Oncology Medical Home model participated in a panel discussion on the first day of The Community Oncology Conference: Innovation in Cancer Care.

On the first day of The Community Oncology Conference: Innovation in Cancer Care, held in Orlando, Florida, April 13-15, 2016, oncologists discussed how their practices are coping with the transition toward quality- and value-based reimbursement.

American workers’ compensation payers experienced a 2.2% increase in pharmacy spending in 2015, but effective management programs helped lower injured workers’ drug utilization by 2.6%.

Adverse drug reaction profiles for 12 marketed antidepressant and anticonvulsant medications are inconsistently reported in Europe versus the United States.

The committee voted 12-1 in favor of delaying approval of the drug and waiting on results from the phase 3 study.

A new study published in The Journal of Urology has found that active surveillance in prostate cancer patients who might have a low-grade disease has the possibility of disease progression in only a small number of patients.

What we're reading, April 13, 2016: scientists find possible "superhero DNA" protecting individuals from debilitating diseases; NPR shines a light on the long wait Native Americans face for healthcare; and doctors rarely discuss weight loss strategies with obese patients.

Cancer pathways can potentially improve patient outcomes and reduce costs. Recent concerns about pathway adoption deserve attention, including excessive administrative burden to clinics.

We offer recommendations for the development and design of clinical pathways in an effort to establish a set of normative criteria that creates trust and transparency.

An updated recommendation by the US Preventive Services Task Force advises the use of low-dose aspirin in adults 50 to 69 years of age, who have an increased risk of cardiovascular disease (CVD) or colorectal cancer (CRC), are not at an increased risk of bleeding, and have a life expectancy of at least 10 years, for the prevention of CVD and CRC.

What we're reading, April 12, 2016: Zika virus scarier than initially thought; KaloBios will adopt a more transparent and "responsible" pricing model for products; and children in rural areas have more complex and expensive hospital stays.

The approval comes following the review of a phase 2 single-arm trial in 106 patients with chronic lymphocytic leukemia who carried the 17p deletion mutation and who had received at least 1 prior therapy for their condition.

Members of the American Society of Clinical Oncology (ASCO) have articulated concerns regarding the current proliferation of clinical pathways in oncology that could affect patient access and care quality. In response, ASCO established an ad hoc Task Force, which issued a policy statement to guide the future development and implementation of these treatment management tools.

What we're reading, April 11, 2016: UnitedHealth calls it quits for 2 Obamacare state exchanges; study finds disparities across country in lifespans of low-income people; and Hillary Clinton and PhRMA agree on one proposal to curb drug costs.

A prospective longitudinal study that followed terminally ill cancer patients till their death has found that patients of African American origins had a poorer understanding of their survival than the white patients in the study group.

Patient-Centered Diabetes Care (PCDC) is important because it provides a venue to share new knowledge and to meet different stakeholders that impact diabetes care, explained Robert A. Gabbay, MD, PhD, FACP, chief medical officer of the Joslin Diabetes Center, chair of PCDC, and editor-in-chief of Evidence-Based Diabetes Management.

The intravenous acetaminophen Ofirmev has been shown to decrease hospital length of stay, opioid-related complications, and overall costs compared with traditional opioid analgesics.