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Cellectis, a clinical-stage biotechnology company, was asked by the FDA to place a clinical hold on 2 phase 1 trials evaluating its allogeneic chimeric antigen receptor-T (CAR-T) cell treatments following the report of a fatality in the first patient treated in one of the studies.

Most emergency department (ED) visits may not be as preventable as once thought. A new study in the International Journal for Quality in Health Care pointed out that while some estimates of "avoidable" ED visits have run anywhere between 4.8% and 90%, the reality is even lower.

The FDA has approved the first 2D digital mammography system that lets patients adjust the level of compression applied to their breast during the imaging procedure.

Quality measurement is here to stay, but a JAMA viewpoint asks if anyone is keeping tabs on the costs of measurement.

According to a study published in The BMJ, while e-cigarettes can assist smokers to quit, the number of days of e-cigarette use will determine quit attempt and quit success.

The assumption in the United States is that once someone with cancer is cured, done with treatment, and healthy, that they are now okay. However, the reality is that survivors contend with lingering challenges that aren’t visible and make it difficult for them to ask for help or admit they need it.

A new draft report from the Institute for Clinical and Economic Review (ICER) indicates that cognitive and mind-body therapies may be valuable additions to usual care for chronic back and neck pain, but that more evidence is needed to understand the cost-effectiveness implications for both conditions.

Psoriasis severity has been linked to increased risk of death in a new study published in the Journal of Investigative Dermatology. Researchers found that the risk of death increased for patients who had more surface area covered by psoriasis.

Despite trials showing that antitumor necrosis factor (TNF) therapy is safe and effective to treat inflammatory diseases such as inflammatory bowel disease and rheumatoid arthritis, but adherence rates remain low.

The rapid-acting insulin received tentative approval based on its similarity to Eli Lilly's Humalog.

The treatment, which was approved nearly 2 decades ago but withdrawn due to safety and efficacy concerns, now has a new indication.

A look at some of the major developments in the chimeric antigen receptor T (CAR-T) cell space.

Desmond Bell, DPM, CWS, said the patients he's seeing in his wound clinic are getting younger, suggesting that the challenge of preventing complications from peripheral artery disease will increase.

This week, the top managed care stories included responses to the disaster in Houston after Hurricane Harvey; the approval of the first gene therapy in the United States; and a new cardiovascular indication for a popular drug to treat type 2 diabetes.

Coverage of our peer-reviewed research in the healthcare and mainstream press.

Less than 2 months after it ordered a stop to 3 trials of pembrolizumab (Keytruda) in multiple myeloma due to safety concerns, the FDA has released a more detailed analysis of what went wrong in these trials.

Among the many exercise tests used to assess patients with chronic obstructive pulmonary disease (COPD), a 6-minute walking test was most strongly associated with patient-reported outcomes and quality of life.

The study finds that the GLP-1 receptor agonist can slow progression of kidney disease, one of the most costly and debilitating complications of type 2 diabetes.

Results of a combination trial evaluating epacadostat with pembrolizumab in advanced melanoma, to be presented at the upcoming European Society for Medical Oncology (ESMO) 2017 Congress, has found that the treatment is well tolerated and has promising clinical activity.

There are positive signs among the youngest children in states where adult obesity rates are highest, but the challenge is to continue that progress as these children get older.

A once-daily treatment that lasts up to 16 hours post-dose for patients older than 13 years who have attention-deficit/hyperactivity disorder (ADHD) is now available in the United States.

A gene therapy for patients with recessive dystrophic epidermolysis bullosa (RDEB), a rare skin disease that causes the skin to be very fragile and blister easily, has been granted Breakthrough Therapy designation status by the FDA.

A new study finds that individuals with advanced cancer have high rates of hospitalization in the year after diagnosis. Palliative care aimed at preventing hospital admissions may be a useful tool, especially for the populations most at risk of rehospitalization.

Through the power of social media, hospitals in Texas are asking nurses from across the country to lend a hand in assisting the overwhelmed staff who have been working overtime to care for survivors of Hurricane Harvey.

The findings will likely add to the controversy over the US dietary guidelines. Lobbyists for grain interests have long been accused of having undue influence in food policy, especially over the now-discarded "food pyramid."