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A genetic risk variant, rs7665090G, located near NFKB1, on astrocytes enhances the accessibility of the central nervous system (CNS) to peripheral immune cells, escalating the risk of autoimmune inflammation and multiple sclerosis (MS), according to the results of a recent study.

Children with Hodgkin lymphoma who are treated during childhood and survive to adulthood have higher incidence rates of breast, lung, colorectal, and thyroid cancer than the general population, according to a recent study.

As the US healthcare system continues to go through major shifts in policy and care delivery, 2018 saw several trends that remained prevalent throughout the year and will likely have significant implications for 2019.

Patients with multiple sclerosis (MS) who are stable on an interferon β (INFβ) should remain on that therapy rather than switching to another INFβ, according to a study in ClinicoEconomics and Outcomes Research.

Researchers have found that sleep disorders, especially insomnia, can impact the prevalence of migraine.

Patients with prognostic characteristics including higher-grade tumors, progesterone receptor (PgR)–negative tumors, liver metastases, and shorter treatment-free intervals derived a greater benefit from the addition of abemaciclib to endocrine therapy (ET) compared with ET alone, according to a recent study.

Despite a meaningful survival, neutropenia is independently associated with poor outcomes among critically ill patients with cancer, according to a new study. However, neutropenia was no longer significantly associated with outcome in patients treated with granulocyte colony-stimulating factor (G-CSF), suggesting a beneficial impact of the treatment.

Patients who are treated with chemotherapy for their solid tumors have an increased risk of therapy-related myelodysplastic syndrome and acute myeloid leukemia (tMDS/AML) despite advances in chemotherapy regimens, according to a new study in JAMA Oncology.

This year, some of the most-read peer-reviewed research published in The American Journal of Managed Care® (AJMC®) explored cost-saving models of care, the benefits and hazards of health information technology, effects of incorporating Choosing Wisely principles into clinical decision support tools, and more.

The Commonwealth Fund report compared the status of health and healthcare for women in the United States to that of 10 other wealthy countries, including the United Kingdom, Canada, Germany, and Australia.

A new poll has found that most Americans support gene editing that is used to protect babies against diseases; Maine’s incoming governor, a Democrat, may be able to ignore the Medicaid work requirements the federal government just approved for the outgoing Republican governor; the new trade agreement between the United States, Canada, and Mexico includes language that could delay cheaper generics from reaching patients.

The Hospital Readmission Reduction Program was announced as part of the Affordable Care Act and penalized hospitals for higher-than-expected 30-day readmissions. However, new research finds that the policy may have done more harm than good with postdischarge mortality increasing for Medicare beneficiaries hospitalized for heart failure and pneumonia.

This week, we recapped the top news from 2018 with a look at policy changes, new research, decisions at the polls, and more.

Males with myeloproliferative neoplasms have worse survival compared with females with MPN, even when adjusted for age at presentation, presenting phenotype, and molecular characteristics.

Metropolitan areas with a minimum wage that was $1 higher at baseline had a 27.12% lower rate of newly diagnosed HIV cases among black residents.

Mature oligodendrocytes have been overlooked in the past as a way to treat multiple sclerosis, but a new study has found they might be able to help with remyelinating axons the same as new oligodendrocytes.

Polycystic ovary syndrome (PCOS) affects 10% of women, but it is often misdiagnosed or missed entirely by physicians. Now, researchers have identified the genetic underpinnings of the syndrome, including 3 new loci, a causal link to depression, and a male phenotype for PCOS.

From chimeric antigen receptor T-cell therapy to value-based contracting, reimbursement issues dominated reader interest.

Of US women between the ages of 15 and 49, 64.9% use some form of contraception, and the use of long-acting reversible contraceptives is increasing; people with prolonged opioid use have an increased risk for cardiovascular problems, but they are also more likely to develop major surgery complications; there are an estimated 11 million undocumented immigrants in the United States, and they struggle to receive basic medical care.

CDC noted a rise in black lung disease, a potentially lethal disease, with a new report of a cluster of 60 cases identified in former and current coal miners at a single eastern Kentucky radiologist’s practice from January 2015 to August 2016.

The authors, led by Kashyap Patel, MD, offer the first in a series of articles on how Carolina Blood and Cancer Care Associates leveraged the strength of its team to take part in the Oncology Care Model.

A study of more than 2000 people with migraine found that red wine was singled out most frequently as a cause of migraine attacks, whereas vodka was indicated least frequently.

Incidence of febrile neutropenia, hospitalizations, and chemotherapy dose reductions and/or delays were similar between short- and long-acting granulocyte-colony stimulating factors, according to a meta-analysis of randomized controlled trials.

One-quarter of the government shut down early Saturday, and as the partial shutdown is expected to continue into the new year, several federal agencies will be impacted, including the FDA.

Long-term nicotine replacement therapy (LT-NRT) provides 1 way for smokers with chronic obstructive pulmonary disease (COPD) to try to quit, but does not result in greater rates of cessation or harm reduction, according to a recently published study.

A recent study looked to evaluate the real-world effectiveness of hepatitis C virus (HCV) treatment in patients with genotype 1 (HCV-1) infection.

A recent trial looked to compare the efficacy and safety of pembrolizumab (Keytruda) with the standard of care for the treatment of head and neck squamous cell carcinoma (SCC).

Patients with the hepatitis C virus (HCV) who are on Medicaid in Oregon can expect to receive curative treatment in 2019 without having to wait for liver damage to set in.

According to a new study, single-tablet regimens may provide better virologic response and control than multiple-tablet regimens for people living with HIV, likely due to a lower pill burden and, subsequently, better medication adherence.