All News

Currently, retinoblastoma (RB) occurs in 1 of every 20,000 births, making it the most common pediatric intraocular neoplasm. The cancer results from biallelic inactivation of the RB1 tumor-suppressor gene, which encodes the nuclear phosphoprotein RB protein.

In a review, researchers outlined the safety and efficacy of erenumab, the only monoclonal antibody built to interact with the calcitonin gene related peptide (CGRP) receptor rather than the CGRP itself, currently indicated as a preventive treatment for migraine.

An online program designed specifically for adolescents and young adults who survived cancer was shown to significantly alleviate insomnia and improve overall quality of life, according to study findings published today.

Among Medicare enrollees, there was substantial between-practice variation in the use of second-generation diabetes drugs between 2007 and 2015, according to a study published in JAMA Network Open. Data also revealed a concentration of use among a few prescribers and practices, who were responsible for widespread early diffusion.

Public health experts and presidentail staffers express frustration over coronavirus disease 2019 (COVID-19) testing comments made by President Trump; the NIH has halted a clinical trial of hydroxychloroquine after data show no harm or benefit in patients with COVID-19; individuals who have obsessive-compulsive disorder may be at greater risk due to added stress from the pandemic.

The study authors tested the risk-reducing effects of ocrelizumab compared with interferon β-1a for treatment of multiple sclerosis disability accumulation, with ocrelizumab showing better results in lowering disability accumulation scores.

Inhaled corticosteroids for patients with chronic obstructive pulmonary disease (COPD) may curb lung function decline, according to new research.

The impact of psoriatic arthritis on quality of life can vary depending on geographic location and culture, according to a global patient survey.

Central nervous system gene therapies and advanced technologies to provide these treatments were noted as emerging opportunities in treatment for neurological conditions such as Parkinson disease, according to review findings. Researchers also highlighted the lack of experience and technology in medical centers nationwide to provide these services.

In a poster titled “Basal Insulins in Advanced Renal Failure: Time for a Paradigm Shift,” authors compared the safety and efficacy of insulin degludec (Tresiba) with insulin glargine 100U (Lantus) among patients with stage 3 and stage 4 chronic kidney disease (CKD).

Most studies of patients with diffuse large B-cell lymphoma do not include those over the age of 80. However, a new study says those patients, like younger patients, benefit from receiving rituximab and anthracycline in their chemotherapy regimens when possible.

A look at the Diabetes Prevention Program at the 10-year mark showed the program brought lasting results.

Regular physical exercise reduces the risk of developing age-related cataracts (ARC), according to a dose-response meta-analysis published in the International Journal of Ophthalmology. ARC is one of the leading causes of vision impairment throughout the world and is estimated to account for 13.4 million cases of blindness.

A new case report highlights the potential links between certain acute cardiac issues and the early stages of multiple sclerosis.

Two studies evaluated how well the dual inhibitor reduced glycated hemoglobin (A1C) while measuring instances of hypoglycemia and other safety measures.

Regardless of smoking status, chronic obstructive pulmonary disease (COPD) is an independent risk factor for developing lung, colorectal, liver and other cancers in the Korean population, according to a study published in BMC Pulmonary Medicine.

In 90% of patients, psoriasis precedes psoriatic arthritis by an average of 7 years, providing a window of opportunity for early intervention and possible prevention of psoriatic arthritis.

Homeless individuals are more likely to be put on ventilators for respiratory infections than non-homeless individuals, according to research published in the Journal of General Internal Medicine.

There is a positive association between having at least 1 chronic disease and adhering to guidelines for breast cancer screening, according to recently published study results.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Diagnosis pediatric acute lymphoblastic leukemia (ALL) can be a costly and cumbersome experience. New research has identified microRNA signatures that could simplify the process of diagnosis and classifying the cancer.

The director of the National Cancer Institute said models predict excess cancer deaths in the thousands due to delayed care and screening; Democratic senators call for an investigation into for-profit institutional review boards; US hospitals begin administering dexamethasone to the sickest patients.

This week, the top managed care news included more details about the COVID-19 vaccine process; attempts to reinforce social distancing amid reopening; a recap of the American Diabetes Association 2020 Virtual Scientific Sessions.

Based on the safety and efficacy outcomes from the PREVENT phase 3 study, the FDA has approved secukinumab (Cosentyx) from Novartis for the treatment of active nonradiographic axial spondyloarthritis.

Jennifer N. Clements, PharmD, is a clinical pharmacist in diabetes transition with Spartanburg Regional Healthcare System in Spartanburg, South Carolina. Clements is a board-certified pharmacotherapy specialist, board-certified ambulatory care pharmacist, and certified diabetes care and education specialist. She is currently developing a pharmacy service focused on the inpatient management of diabetes. An editor from The American Journal of Managed Care® recently conducted an interview with Clements to discuss strategies for improving transitions of care for patients with diabetes.

An advanced, noninvasive MRI technique in patients with Parkinson disease and essential tremor was found to potentially lead to better outcomes without surgery and lessen risk of adverse effects, according to study findings published this week.

Scientists at the Trinity College Dublin and University College London developed a new gene therapy approach that has the potential to treat a group of eye diseases known as retinitis pigmentosa (RP), according to research published in Stem Cell Reports.

The American Society of Hematology has adopted 10 of the recommendations from Choosing Wisely to encourage more high-value care, but barriers to adoption remain.

The decade spanning 2007 through 2017 saw an intensified focus on reducing hospital readmissions among patients with heart failure receiving care in the Veterans Affairs Health Care System.

Administrator Seema Verma said the proposal would create opportunities "for drug manufacturers to have skin in the game through payment arrangements that challenge them to put their money where their mouth is."