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Metastatic disease is the leading cause of death in the over 600,000 individuals worldwide who die of breast cancer each year. A new blood-based assay to detect minimal residual disease (MRD) in patients with stage 0 to 3 breast cancer was shown to have 100-fold greater sensitivity compared with digital droplet polymerase chain reaction.

pharmacytimes.org/on-demand/a-managed-care-review-of-unmet-medical-needs-new-treatments-and-health-economics-associated-with-schizophrenia-supplement

If you have a primary care relationship, there is at least one health care provider who does know you: your primary care physician (PCP). Yet in the turmoil of admission and the danger of discharge, it has often been likely that the only physician on earth who knows you and your health would never know that you spent 3 days in the hospital. That is, until you recovered and told the person.

While the cell and gene therapies approved so far are indicated for rare diseases with small patient populations, the successes of chimeric antigen receptor-T (CAR-T) therapies and expanding interest from biopharma stress the need to rapidly scale the supply chain as these therapies move toward commercial availability for more disease states and larger patient populations.

Children were found to exhibit distinct type 1 diabetes endotypes compared with older adolescents; DNA testing has shown to be beneficial but controversial when personlizing care for patients with breast cancer; artifical intelligence (AI) usage across healthcare.

The association of HIV infection with cardiovascular disease was particularly strong for heart failure and stroke.

Platelet indices may be altered in chronic obstructive pulmonary disease and therefore act as a valuable diagnostic marker, according to research.

Men demonstrated higher levels of respiratory events and more periodic limb movements but women had significantly higher levels of sleep-associated complaints across all measures.

Harvard's Ashish Jha, MD, MPH, was senior author on a popular 2015 paper that addressed care fragmentation among those with chronic illness.

Changes in brain tissue iron relate to poorer cognition in Parkinson disease, according to a recent study.

A new study lends depth to the understanding of endogenous Candida endophthalmitis by comparing imagery from optical coherence tomography both before and after treatment.

Family history with migraine affect male and female patients differently, according to a recent study.

A new review article highlights the remaining challenge to making a meaningful immunotherapy to combat acute myeloid lymphoma (AML).

Overall, however, the FDA has reported 12 cases of dyshidrotic eczema caused by secukinumab, the investigators noted.

The most popular stories of the week on AJMC®.

Amid the COVID-19 pandemic, patients, as well as their physicians, have been put at risk while seeking or providing other healthcare. While several barriers to care have inhibited telehealth in the past, recent actions by CMS, HHS, and other governing bodies have sought to expand its availability nationwide. NYU Langone Health's telehealth service Virtual Urgent Care connects members with clinicians via phone or tablet to provide care without potential coronavirus exposure.

President Donald Trump on Friday declared the novel coronavirus a national emergency, which unlocks billions of dollars in federal funding to fight the disease’s spread. He also announced the creation of a website to direct symptomatic individuals to drive-through testing locations.

A primary analysis of data from the GeparOcto trial showed no difference in pathologic complete response among patients with early-stage breast cancer enrolled in 2 neoadjuvant treatment arms: sequential intense dose-dense epirubicin, paclitaxel, and cyclophosphamide and weekly paclitaxel and nonpegylated liposomal doxorubicin.

This week, top managed care news included WHO declaring coronavirus a pandemic; CMS’ creation of an insulin savings plan for seniors; racial bias from professionals as a factor in low minority participation in clinical trials.

Two individuals died after recieveing stool transplants; a CDC report highlights a lack of action on binge drinking; Congress has approved a food aid measure for seniors.

Coverage of our peer-reviewed research and news reporting in the healthcare and mainstream press.

Patients who undergo neoadjuvant chemotherapy tend to be younger, with larger tumors and greater nodal involvement. But differences in their 30- and 90-day mortality rates compared with those of patients treated adjuvantly are clinically insignificant.

Risk factors for suicidal ideation and behaviors in children aged 9 and 10, however, include psychological issues, conflict within the family, and increased use of computers on weekends, especially for boys.

Toddlers with reported diminished sleep duration and quality during infancy had a greater likelihood of emotional and behavioral problems, with associations proving strongest for internalizing and dysregulation symptoms, according to study findings.

The FDA granted a fast track designation to Jardiance (empagliflozin) for treatment of chronic kidney disease; a new review in the New England Journal of Medicine urges physicians to prepare for self-managed abortion complications; Alcoholics Anonymous is more effective than other common abstinence treatments.

Investigators tracked time to treatment for 3 types of cancer in states that expanded Medicaid coverage on January 1, 2014, comparing rates before and after the expansion. Patients with new diagnoses of invasive breast, colon, or lung cancers aged 40 to 64 years were included in the analysis.

Patients with cardiovascular disease are especially vulnerable to respiratory infections, although uncertainty remains on just what damage COVID-19 can cause in these patients. The flu season is also in full swing, with an estimated 440,000 individuals hospitalized so far in the United States alone, according to the CDC.

From funding innovative research to advocating for government action to providing a support structure for our community, no other organization does more to fight type 1 diabetes (T1D) than JDRF.

Patients with Parkinson disease were found to be more likely to experience vision and eye issues, such as blurry vision, dry eyes, trouble with depth perception, and problems adjusting to rapid changes in light, compared with people without the disorder, according to study findings.